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In vivo evaluation of blood based and reference tissue based PET quantifications of [11C]DASB in the canine brain

(2016) PLOS ONE. 11(2).
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Abstract
This first-in-dog study evaluates the use of the PET-radioligand [C-11] DASB to image the density and availability of the serotonin transporter (SERT) in the canine brain. Imaging the serotonergic system could improve diagnosis and therapy of multiple canine behavioural disorders. Furthermore, as many similarities are reported between several human neuropsychiatric conditions and naturally occurring canine behavioural disorders, making this tracer available for use in dogs also provide researchers an interesting non-primate animal model to investigate human disorders. Five adult beagles underwent a 90 minutes dynamic PET scan and arterial whole blood was sampled throughout the scan. For each ROI, the distribution volume (V-T), obtained via the one-and two-tissue compartment model (1-TC, 2-TC) and the Logan Plot, was calculated and the goodness-of-fit was evaluated by the Akaike Information Criterion (AIC). For the preferred compartmental model BPND values were estimated and compared with those derived by four reference tissue models: 4-parameter RTM, SRTM2, MRTM2 and the Logan reference tissue model. The 2-TC model indicated in 61% of the ROIs a better fit compared to the 1-TC model. The Logan plot produced almost identical VT values and can be used as an alternative. Compared with the 2-TC model, all investigated reference tissue models showed high correlations but small underestimations of the BPND-parameter. The highest correlation was achieved with the Logan reference tissue model (Y = 0.9266 x + 0.0257; R-2 = 0.9722). Therefore, this model can be put forward as a non-invasive standard model for future PET-experiments with [C-11] DASB in dogs.
Keywords
C-11-DASB, RADIOLIGANDS, BINDING, RECEPTOR, MODEL, HIGH-QUALITY, HEALTHY HUMANS, GRAPHICAL ANALYSIS, HUMAN SEROTONIN TRANSPORTER, POSITRON-EMISSION-TOMOGRAPHY

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MLA
Van Laeken, Nick et al. “In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain.” PLOS ONE 11.2 (2016): n. pag. Print.
APA
Van Laeken, N., Taylor, O., Polis, I., Neyt, S., Kersemans, K., Dobbeleir, A., Saunders, J., et al. (2016). In vivo evaluation of blood based and reference tissue based PET quantifications of [11C]DASB in the canine brain. PLOS ONE, 11(2).
Chicago author-date
Van Laeken, Nick, Olivia Taylor, Ingeborgh Polis, Sara Neyt, Ken Kersemans, Andre Dobbeleir, Jimmy Saunders, Ingeborg Goethals, Kathelijne Peremans, and Filip De Vos. 2016. “In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain.” Plos One 11 (2).
Chicago author-date (all authors)
Van Laeken, Nick, Olivia Taylor, Ingeborgh Polis, Sara Neyt, Ken Kersemans, Andre Dobbeleir, Jimmy Saunders, Ingeborg Goethals, Kathelijne Peremans, and Filip De Vos. 2016. “In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain.” Plos One 11 (2).
Vancouver
1.
Van Laeken N, Taylor O, Polis I, Neyt S, Kersemans K, Dobbeleir A, et al. In vivo evaluation of blood based and reference tissue based PET quantifications of [11C]DASB in the canine brain. PLOS ONE. 2016;11(2).
IEEE
[1]
N. Van Laeken et al., “In vivo evaluation of blood based and reference tissue based PET quantifications of [11C]DASB in the canine brain,” PLOS ONE, vol. 11, no. 2, 2016.
@article{7242433,
  abstract     = {This first-in-dog study evaluates the use of the PET-radioligand [C-11] DASB to image the density and availability of the serotonin transporter (SERT) in the canine brain. Imaging the serotonergic system could improve diagnosis and therapy of multiple canine behavioural disorders. Furthermore, as many similarities are reported between several human neuropsychiatric conditions and naturally occurring canine behavioural disorders, making this tracer available for use in dogs also provide researchers an interesting non-primate animal model to investigate human disorders. Five adult beagles underwent a 90 minutes dynamic PET scan and arterial whole blood was sampled throughout the scan. For each ROI, the distribution volume (V-T), obtained via the one-and two-tissue compartment model (1-TC, 2-TC) and the Logan Plot, was calculated and the goodness-of-fit was evaluated by the Akaike Information Criterion (AIC). For the preferred compartmental model BPND values were estimated and compared with those derived by four reference tissue models: 4-parameter RTM, SRTM2, MRTM2 and the Logan reference tissue model. The 2-TC model indicated in 61% of the ROIs a better fit compared to the 1-TC model. The Logan plot produced almost identical VT values and can be used as an alternative. Compared with the 2-TC model, all investigated reference tissue models showed high correlations but small underestimations of the BPND-parameter. The highest correlation was achieved with the Logan reference tissue model (Y = 0.9266 x + 0.0257; R-2 = 0.9722). Therefore, this model can be put forward as a non-invasive standard model for future PET-experiments with [C-11] DASB in dogs.},
  articleno    = {e0148943},
  author       = {Van Laeken, Nick and Taylor, Olivia and Polis, Ingeborgh and Neyt, Sara and Kersemans, Ken and Dobbeleir, Andre and Saunders, Jimmy and Goethals, Ingeborg and Peremans, Kathelijne and De Vos, Filip},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {C-11-DASB,RADIOLIGANDS,BINDING,RECEPTOR,MODEL,HIGH-QUALITY,HEALTHY HUMANS,GRAPHICAL ANALYSIS,HUMAN SEROTONIN TRANSPORTER,POSITRON-EMISSION-TOMOGRAPHY},
  language     = {eng},
  number       = {2},
  pages        = {12},
  title        = {In vivo evaluation of blood based and reference tissue based PET quantifications of [11C]DASB in the canine brain},
  url          = {http://dx.doi.org/10.1371/journal.pone.0148943},
  volume       = {11},
  year         = {2016},
}

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