Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study
- Author
- RJT Mocking, CA Figueroa, MM Rive, H Geugies, MN Servaas, J Assies, MWJ Koeter, FM Vaz, M Wichers, JP van Straalen, Rudi De Raedt (UGent) , CLH Bockting, CJ Harmer, AH Schene and HG Ruhe
- Organization
- Abstract
- Introduction Major depressive disorder (MDD) is widely prevalent and severely disabling, mainly due to its recurrent nature. A better understanding of the mechanisms underlying MDD-recurrence may help to identify high-risk patients and to improve the preventive treatment they need. MDD-recurrence has been considered from various levels of perspective including symptomatology, affective neuropsychology, brain circuitry and endocrinology/metabolism. However, MDD-recurrence understanding is limited, because these perspectives have been studied mainly in isolation, cross-sectionally in depressed patients. Therefore, we aim at improving MDD-recurrence understanding by studying these four selected perspectives in combination and prospectively during remission. Methods and analysis In a cohort design, we will include 60 remitted, unipolar, unmedicated, recurrent MDD-participants (35-65years) with 2 MDD-episodes. At baseline, we will compare the MDD-participants with 40 matched controls. Subsequently, we will follow-up the MDD-participants for 2.5years while monitoring recurrences. We will invite participants with a recurrence to repeat baseline measurements, together with matched remitted MDD-participants. Measurements include questionnaires, sad mood-induction, lifestyle/diet, 3T structural (T1-weighted and diffusion tensor imaging) and blood-oxygen-level-dependent functional MRI (fMRI) and MR-spectroscopy. fMRI focusses on resting state, reward/aversive-related learning and emotion regulation. With affective neuropsychological tasks we will test emotional processing. Moreover, we will assess endocrinology (salivary hypothalamic-pituitary-adrenal-axis cortisol and dehydroepiandrosterone-sulfate) and metabolism (metabolomics including polyunsaturated fatty acids), and store blood for, for example, inflammation analyses, genomics and proteomics. Finally, we will perform repeated momentary daily assessments using experience sampling methods at baseline. We will integrate measures to test: (1) differences between MDD-participants and controls; (2) associations of baseline measures with retro/prospective recurrence-rates; and (3) repeated measures changes during follow-up recurrence. This data set will allow us to study different predictors of recurrence in combination. Ethics and dissemination The local ethics committee approved this study (AMC-METC-Nr.:11/050). We will submit results for publication in peer-reviewed journals and presentation at (inter)national scientific meetings. Trial registration number NTR3768.
- Keywords
- MAGNETIC-RESONANCE-SPECTROSCOPY, STATE FUNCTIONAL CONNECTIVITY, PREVENTIVE COGNITIVE THERAPY, DYSFUNCTIONAL ATTITUDE SCALE, RANDOMIZED CONTROLLED-TRIAL, ANTERIOR CINGULATE CORTEX, NEGATIVE BOLD RESPONSES, VOXEL-BASED MORPHOMETRY, PITUITARY-ADRENAL-AXIS, DEFAULT-MODE NETWORK, STATISTICS & RESEARCH METHODS, PREVENTIVE MEDICINE
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-7242223
- MLA
- Mocking, RJT, et al. “Vulnerability for New Episodes in Recurrent Major Depressive Disorder: Protocol for the Longitudinal DELTA-Neuroimaging Cohort Study.” BMJ OPEN, vol. 6, no. 3, BMJ PUBLISHING GROUP, 2016, doi:10.1136/bmjopen-2015-009510.
- APA
- Mocking, R., Figueroa, C., Rive, M., Geugies, H., Servaas, M., Assies, J., … Ruhe, H. (2016). Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study. BMJ OPEN, 6(3). https://doi.org/10.1136/bmjopen-2015-009510
- Chicago author-date
- Mocking, RJT, CA Figueroa, MM Rive, H Geugies, MN Servaas, J Assies, MWJ Koeter, et al. 2016. “Vulnerability for New Episodes in Recurrent Major Depressive Disorder: Protocol for the Longitudinal DELTA-Neuroimaging Cohort Study.” BMJ OPEN 6 (3). https://doi.org/10.1136/bmjopen-2015-009510.
- Chicago author-date (all authors)
- Mocking, RJT, CA Figueroa, MM Rive, H Geugies, MN Servaas, J Assies, MWJ Koeter, FM Vaz, M Wichers, JP van Straalen, Rudi De Raedt, CLH Bockting, CJ Harmer, AH Schene, and HG Ruhe. 2016. “Vulnerability for New Episodes in Recurrent Major Depressive Disorder: Protocol for the Longitudinal DELTA-Neuroimaging Cohort Study.” BMJ OPEN 6 (3). doi:10.1136/bmjopen-2015-009510.
- Vancouver
- 1.Mocking R, Figueroa C, Rive M, Geugies H, Servaas M, Assies J, et al. Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study. BMJ OPEN. 2016;6(3).
- IEEE
- [1]R. Mocking et al., “Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study,” BMJ OPEN, vol. 6, no. 3, 2016.
@article{7242223, abstract = {{Introduction Major depressive disorder (MDD) is widely prevalent and severely disabling, mainly due to its recurrent nature. A better understanding of the mechanisms underlying MDD-recurrence may help to identify high-risk patients and to improve the preventive treatment they need. MDD-recurrence has been considered from various levels of perspective including symptomatology, affective neuropsychology, brain circuitry and endocrinology/metabolism. However, MDD-recurrence understanding is limited, because these perspectives have been studied mainly in isolation, cross-sectionally in depressed patients. Therefore, we aim at improving MDD-recurrence understanding by studying these four selected perspectives in combination and prospectively during remission. Methods and analysis In a cohort design, we will include 60 remitted, unipolar, unmedicated, recurrent MDD-participants (35-65years) with 2 MDD-episodes. At baseline, we will compare the MDD-participants with 40 matched controls. Subsequently, we will follow-up the MDD-participants for 2.5years while monitoring recurrences. We will invite participants with a recurrence to repeat baseline measurements, together with matched remitted MDD-participants. Measurements include questionnaires, sad mood-induction, lifestyle/diet, 3T structural (T1-weighted and diffusion tensor imaging) and blood-oxygen-level-dependent functional MRI (fMRI) and MR-spectroscopy. fMRI focusses on resting state, reward/aversive-related learning and emotion regulation. With affective neuropsychological tasks we will test emotional processing. Moreover, we will assess endocrinology (salivary hypothalamic-pituitary-adrenal-axis cortisol and dehydroepiandrosterone-sulfate) and metabolism (metabolomics including polyunsaturated fatty acids), and store blood for, for example, inflammation analyses, genomics and proteomics. Finally, we will perform repeated momentary daily assessments using experience sampling methods at baseline. We will integrate measures to test: (1) differences between MDD-participants and controls; (2) associations of baseline measures with retro/prospective recurrence-rates; and (3) repeated measures changes during follow-up recurrence. This data set will allow us to study different predictors of recurrence in combination. Ethics and dissemination The local ethics committee approved this study (AMC-METC-Nr.:11/050). We will submit results for publication in peer-reviewed journals and presentation at (inter)national scientific meetings. Trial registration number NTR3768.}}, articleno = {{e009510}}, author = {{Mocking, RJT and Figueroa, CA and Rive, MM and Geugies, H and Servaas, MN and Assies, J and Koeter, MWJ and Vaz, FM and Wichers, M and van Straalen, JP and De Raedt, Rudi and Bockting, CLH and Harmer, CJ and Schene, AH and Ruhe, HG}}, issn = {{2044-6055}}, journal = {{BMJ OPEN}}, keywords = {{MAGNETIC-RESONANCE-SPECTROSCOPY,STATE FUNCTIONAL CONNECTIVITY,PREVENTIVE COGNITIVE THERAPY,DYSFUNCTIONAL ATTITUDE SCALE,RANDOMIZED CONTROLLED-TRIAL,ANTERIOR CINGULATE CORTEX,NEGATIVE BOLD RESPONSES,VOXEL-BASED MORPHOMETRY,PITUITARY-ADRENAL-AXIS,DEFAULT-MODE NETWORK,STATISTICS & RESEARCH METHODS,PREVENTIVE MEDICINE}}, language = {{eng}}, number = {{3}}, pages = {{17}}, publisher = {{BMJ PUBLISHING GROUP}}, title = {{Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study}}, url = {{http://doi.org/10.1136/bmjopen-2015-009510}}, volume = {{6}}, year = {{2016}}, }
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