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Spinal radiographic changes in ankylosing spondylitis: association with clinical characteristics and functional outcome

Annelies Boonen, Bert Vander Cruyssen UGent, Kurt de Vlam, Serge Steinfeld, Clio Ribbens, Jan Lenaerts, Filip Van den Bosch UGent, Lode Dewulf and Nathan Vastesaeger (2009) JOURNAL OF RHEUMATOLOGY. 36(6). p.1249-1255
abstract
Objective. To determine which patients with ankylosing spondylitis (AS) have radiographic spinal damage and to investigate the relation between radio,graphic spinal changes and limitations in physical function. Methods. A cross-sectional nationwide study in Belgium of patients with AS under the care of a rheumatologist. The treating physician completed a questionnaire including clinical disease manifestations and laboratory findings (HLA-B27 and C-reactive protein), and classified spinal radiographs into 3 categories: (1) no AS-related spinal abnormalities (2) syndesmophytes; and (3) spinal ankylosis. Patients completed the Bath AS Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI). Ordinal regressions were performed to quantify the relationship between clinical manifestations and spinal radiographic changes. Generalized linear models were computed to quantity relationships among clinical manifestations, radiographic spinal changes, and functioning (BASFI). Results. A total of 619 patients fulfilled modified New York criteria for definite AS and had evaluable radiographic data; 68% were male and disease duration was 17.5 (SD 12.2) years. Male sex, younger age at symptom onset, and hip involvement were associated with radiographic changes but HLA-B27, peripheral arthritis, and extraarticular disease status (uveitis, psoriasis, and inflammatory bowel disease) were not. Older age, BASDAI, hip involvement, and spinal change contributed to BASFI: but sex, disease duration, peripheral arthritis, and extraarticular manifestations did not. Conclusion. Radiographic spinal changes in patients with AS are seen more often in men and those with hip involvement. BASFI status indicates the influence of radiographic changes and hip involvement, but does not reflect the presence of peripheral arthritis and does not differ between men and women.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
JOURNAL OF RHEUMATOLOGY
J. Rheumatol.
volume
36
issue
6
pages
1249 - 1255
Web of Science type
Article
Web of Science id
000266891500027
JCR category
RHEUMATOLOGY
JCR impact factor
3.854 (2009)
JCR rank
10/24 (2009)
JCR quartile
2 (2009)
ISSN
0315-162X
DOI
10.3899/jrheum.080831
language
English
UGent publication?
yes
classification
A1
id
723943
handle
http://hdl.handle.net/1854/LU-723943
date created
2009-08-07 15:14:32
date last changed
2016-12-19 15:46:05
@article{723943,
  abstract     = {Objective. To determine which patients with ankylosing spondylitis (AS) have radiographic spinal damage and to investigate the relation between radio,graphic spinal changes and limitations in physical function.

Methods. A cross-sectional nationwide study in Belgium of patients with AS under the care of a rheumatologist. The treating physician completed a questionnaire including clinical disease manifestations and laboratory findings (HLA-B27 and C-reactive protein), and classified spinal radiographs into 3 categories: (1) no AS-related spinal abnormalities (2) syndesmophytes; and (3) spinal ankylosis. Patients completed the Bath AS Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI). Ordinal regressions were performed to quantify the relationship between clinical manifestations and spinal radiographic changes. Generalized linear models were computed to quantity relationships among clinical manifestations, radiographic spinal changes, and functioning (BASFI).

Results. A total of 619 patients fulfilled modified New York criteria for definite AS and had evaluable radiographic data; 68\% were male and disease duration was 17.5 (SD 12.2) years. Male sex, younger age at symptom onset, and hip involvement were associated with radiographic changes but HLA-B27, peripheral arthritis, and extraarticular disease status (uveitis, psoriasis, and inflammatory bowel disease) were not. Older age, BASDAI, hip involvement, and spinal change contributed to BASFI: but sex, disease duration, peripheral arthritis, and extraarticular manifestations did not.

Conclusion. Radiographic spinal changes in patients with AS are seen more often in men and those with hip involvement. BASFI status indicates the influence of radiographic changes and hip involvement, but does not reflect the presence of peripheral arthritis and does not differ between men and women.},
  author       = {Boonen, Annelies and Vander Cruyssen, Bert and de Vlam, Kurt and Steinfeld, Serge and Ribbens, Clio and Lenaerts, Jan and Van den Bosch, Filip and Dewulf, Lode and Vastesaeger, Nathan},
  issn         = {0315-162X},
  journal      = {JOURNAL OF RHEUMATOLOGY},
  language     = {eng},
  number       = {6},
  pages        = {1249--1255},
  title        = {Spinal radiographic changes in ankylosing spondylitis: association with clinical characteristics and functional outcome},
  url          = {http://dx.doi.org/10.3899/jrheum.080831},
  volume       = {36},
  year         = {2009},
}

Chicago
Boonen, Annelies, Bert Vander Cruyssen, Kurt de Vlam, Serge Steinfeld, Clio Ribbens, Jan Lenaerts, Filip Van den Bosch, Lode Dewulf, and Nathan Vastesaeger. 2009. “Spinal Radiographic Changes in Ankylosing Spondylitis: Association with Clinical Characteristics and Functional Outcome.” Journal of Rheumatology 36 (6): 1249–1255.
APA
Boonen, Annelies, Vander Cruyssen, B., de Vlam, K., Steinfeld, S., Ribbens, C., Lenaerts, J., Van den Bosch, F., et al. (2009). Spinal radiographic changes in ankylosing spondylitis: association with clinical characteristics and functional outcome. JOURNAL OF RHEUMATOLOGY, 36(6), 1249–1255.
Vancouver
1.
Boonen A, Vander Cruyssen B, de Vlam K, Steinfeld S, Ribbens C, Lenaerts J, et al. Spinal radiographic changes in ankylosing spondylitis: association with clinical characteristics and functional outcome. JOURNAL OF RHEUMATOLOGY. 2009;36(6):1249–55.
MLA
Boonen, Annelies, Bert Vander Cruyssen, Kurt de Vlam, et al. “Spinal Radiographic Changes in Ankylosing Spondylitis: Association with Clinical Characteristics and Functional Outcome.” JOURNAL OF RHEUMATOLOGY 36.6 (2009): 1249–1255. Print.