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Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo

Chang Sup Lee, Kristen K Penberthy, Karen M Wheeler, Ignacio J Juncadella, Peter Vandenabeele UGent, Jeffrey J Lysiak and Kodi S Ravichandran (2016) IMMUNITY. 44(4). p.807-820
abstract
Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated. Consistent with this, BAI1-deficient mice had more pronounced colitis and lower survival, with many uncleared apoptotic corpses and inflammatory cytokines within the colonic epithelium. When we engineered and tested transgenic mice overexpressing BAI1, these had fewer apoptotic cells, reduced inflammation, and attenuated disease. Boosting BAI1-mediated uptake by intestinal epithelial cells (rather than myeloid cells) was important in attenuating inflammation. A signaling-deficient BAI1 transgene could not provide a similar benefit. Collectively, these complementary genetic approaches showed that cell clearance could be boosted in vivo, with potential to regulate tissue inflammation in specific contexts.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BOWEL-DISEASE, MAMMARY-GLAND, CROHNS-DISEASE, ULCERATIVE-COLITIS, TNF-ALPHA, PHOSPHATIDYLSERINE EXPOSURE, IMMUNE HOMEOSTASIS, AUTOIMMUNE-DISEASE, GENE-EXPRESSION, RECEPTOR
journal title
IMMUNITY
Immunity
volume
44
issue
4
pages
807 - 820
Web of Science type
Article
Web of Science id
000374444300013
JCR category
IMMUNOLOGY
JCR impact factor
22.845 (2016)
JCR rank
3/150 (2016)
JCR quartile
1 (2016)
ISSN
1074-7613
DOI
10.1016/j.immuni.2016.02.005
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7236140
handle
http://hdl.handle.net/1854/LU-7236140
date created
2016-05-27 15:17:39
date last changed
2016-12-19 15:47:29
@article{7236140,
  abstract     = {Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated. Consistent with this, BAI1-deficient mice had more pronounced colitis and lower survival, with many uncleared apoptotic corpses and inflammatory cytokines within the colonic epithelium. When we engineered and tested transgenic mice overexpressing BAI1, these had fewer apoptotic cells, reduced inflammation, and attenuated disease. Boosting BAI1-mediated uptake by intestinal epithelial cells (rather than myeloid cells) was important in attenuating inflammation. A signaling-deficient BAI1 transgene could not provide a similar benefit. Collectively, these complementary genetic approaches showed that cell clearance could be boosted in vivo, with potential to regulate tissue inflammation in specific contexts.},
  author       = {Lee, Chang Sup and Penberthy, Kristen K and Wheeler, Karen M and Juncadella, Ignacio J and Vandenabeele, Peter and Lysiak, Jeffrey J and Ravichandran, Kodi S},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {BOWEL-DISEASE,MAMMARY-GLAND,CROHNS-DISEASE,ULCERATIVE-COLITIS,TNF-ALPHA,PHOSPHATIDYLSERINE EXPOSURE,IMMUNE HOMEOSTASIS,AUTOIMMUNE-DISEASE,GENE-EXPRESSION,RECEPTOR},
  language     = {eng},
  number       = {4},
  pages        = {807--820},
  title        = {Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo},
  url          = {http://dx.doi.org/10.1016/j.immuni.2016.02.005},
  volume       = {44},
  year         = {2016},
}

Chicago
Lee, Chang Sup, Kristen K Penberthy, Karen M Wheeler, Ignacio J Juncadella, Peter Vandenabeele, Jeffrey J Lysiak, and Kodi S Ravichandran. 2016. “Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation in Vivo.” Immunity 44 (4): 807–820.
APA
Lee, C. S., Penberthy, K. K., Wheeler, K. M., Juncadella, I. J., Vandenabeele, P., Lysiak, J. J., & Ravichandran, K. S. (2016). Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo. IMMUNITY, 44(4), 807–820.
Vancouver
1.
Lee CS, Penberthy KK, Wheeler KM, Juncadella IJ, Vandenabeele P, Lysiak JJ, et al. Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo. IMMUNITY. 2016;44(4):807–20.
MLA
Lee, Chang Sup, Kristen K Penberthy, Karen M Wheeler, et al. “Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation in Vivo.” IMMUNITY 44.4 (2016): 807–820. Print.