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The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

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Abstract
Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain-and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.
Keywords
GROWTH-FACTOR RECEPTOR, LIGAND-INDEPENDENT ACTIVATION, IN-VIVO, ST2 RECEPTOR, P38 MAPK, CD8(+) T, ANGIOGENESIS, CANCER, ZEBRAFISH, INFLAMMATION

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Chicago
Yang, Yunlong, Patrik Andersson, Kayoko Hosaka, Yin Zhang, Renhai Cao, Hideki Iwamoto, Xiaojuan Yang, et al. 2016. “The PDGF-BB-SOX7 Axis-modulated IL-33 in Pericytes and Stromal Cells Promotes Metastasis Through Tumour-associated Macrophages.” Nature Communications 7.
APA
Yang, Yunlong, Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., et al. (2016). The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. NATURE COMMUNICATIONS, 7.
Vancouver
1.
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. NATURE COMMUNICATIONS. 2016;7.
MLA
Yang, Yunlong, Patrik Andersson, Kayoko Hosaka, et al. “The PDGF-BB-SOX7 Axis-modulated IL-33 in Pericytes and Stromal Cells Promotes Metastasis Through Tumour-associated Macrophages.” NATURE COMMUNICATIONS 7 (2016): n. pag. Print.
@article{7236095,
  abstract     = {Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33-ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain-and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33-ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.},
  articleno    = {11385},
  author       = {Yang, Yunlong and Andersson, Patrik and Hosaka, Kayoko and Zhang, Yin and Cao, Renhai and Iwamoto, Hideki and Yang, Xiaojuan and Nakamura, Masaki and Wang, Jian and Zhuang, Rujie and Morikawa, Hiromasa and Xue, Yuan and Braun, Harald and Beyaert, Rudi and Samani, Nilesh and Nakae, Susume and Hams, Emily and Dissing, Steen and Fallon, Padraic G and Langer, Robert and Cao, Yihai},
  issn         = {2041-1723},
  journal      = {NATURE COMMUNICATIONS},
  keyword      = {GROWTH-FACTOR RECEPTOR,LIGAND-INDEPENDENT ACTIVATION,IN-VIVO,ST2 RECEPTOR,P38 MAPK,CD8(+) T,ANGIOGENESIS,CANCER,ZEBRAFISH,INFLAMMATION},
  language     = {eng},
  pages        = {18},
  title        = {The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages},
  url          = {http://dx.doi.org/10.1038/ncomms11385},
  volume       = {7},
  year         = {2016},
}

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