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Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Zhiyue Zhang (UGent) , Bert Schepens (UGent) , Lutz Nuhn (UGent) , Xavier Saelens (UGent) , Michael Schotsaert (UGent) , Nico Callewaert (UGent) , Riet De Rycke (UGent) , Qilu Zhang (UGent) , Sébastien Moins, Samira Benali, et al.
(2016) CHEMICAL COMMUNICATIONS. 52(16). p.3352-3355
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Abstract
We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-alpha-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.
Keywords
GLYCONANOPARTICLES, HEMAGGLUTININ, SIALOSIDE GROUPS, BIOLOGICAL-SYSTEMS, MULTIVALENCY, VIRUS, NEURAMINIDASE, INHIBITORS, LIGAND, DESIGN

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Chicago
Zhang, Zhiyue, Bert Schepens, Lutz Nuhn, Xavier Saelens, Michael Schotsaert, Nico Callewaert, Riet De Rycke, et al. 2016. “Influenza-binding Sialylated Polymer Coated Gold Nanoparticles Prepared via RAFT Polymerization and Reductive Amination.” Chemical Communications 52 (16): 3352–3355.
APA
Zhang, Zhiyue, Schepens, B., Nuhn, L., Saelens, X., Schotsaert, M., Callewaert, N., De Rycke, R., et al. (2016). Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination. CHEMICAL COMMUNICATIONS, 52(16), 3352–3355.
Vancouver
1.
Zhang Z, Schepens B, Nuhn L, Saelens X, Schotsaert M, Callewaert N, et al. Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination. CHEMICAL COMMUNICATIONS. 2016;52(16):3352–5.
MLA
Zhang, Zhiyue, Bert Schepens, Lutz Nuhn, et al. “Influenza-binding Sialylated Polymer Coated Gold Nanoparticles Prepared via RAFT Polymerization and Reductive Amination.” CHEMICAL COMMUNICATIONS 52.16 (2016): 3352–3355. Print.
@article{7224591,
  abstract     = {We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-alpha-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.},
  author       = {Zhang, Zhiyue and Schepens, Bert and Nuhn, Lutz and Saelens, Xavier and Schotsaert, Michael and Callewaert, Nico and De Rycke, Riet and Zhang, Qilu and Moins, Sébastien and Benali, Samira and Mespouille, Laetitia and Hoogenboom, Richard and De Geest, Bruno},
  issn         = {1359-7345},
  journal      = {CHEMICAL COMMUNICATIONS},
  keywords     = {GLYCONANOPARTICLES,HEMAGGLUTININ,SIALOSIDE GROUPS,BIOLOGICAL-SYSTEMS,MULTIVALENCY,VIRUS,NEURAMINIDASE,INHIBITORS,LIGAND,DESIGN},
  language     = {eng},
  number       = {16},
  pages        = {3352--3355},
  title        = {Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination},
  url          = {http://dx.doi.org/10.1039/c6cc00501b},
  volume       = {52},
  year         = {2016},
}

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