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Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep

Charlotte Van Herzeele (UGent) , Karlien Dhondt (UGent) , Sanne Roels (UGent) , Ann Raes (UGent) , Piet Hoebeke (UGent) , LUITZEN ALBERT GROEN (UGent) and Johan Vande Walle (UGent)
(2016) PEDIATRIC NEPHROLOGY. 31(9). p.1477-1484
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Abstract
There is a high comorbidity between nocturnal enuresis, sleep disorders and psychological problems. The aim of this study was to investigate whether a decrease in nocturnal diuresis volume not only improves enuresis but also ameliorates disrupted sleep and (neuro)psychological dysfunction, the major comorbidities of this disorder. In this open-label, prospective phase IV study, 30 children with monosymptomatic nocturnal enuresis (MNE) underwent standardized video-polysomnographic testing and multi-informant (neuro)psychological testing at baseline and 6 months after the start of desmopressin treatment in the University Hospital Ghent, Belgium. Primary endpoints were the effect on sleep and (neuro)psychological functioning. The secondary endpoint was the change in the first undisturbed sleep period or the time to the first void. Thirty children aged between 6 and 16 (mean 10.43, standard deviation 3.08) years completed the study. The results demonstrated a significant decrease in periodic limb movements during sleep (PLMS) and a prolonged first undisturbed sleep period. Additionally, (neuro)psychological functioning was improved on several domains. The study demonstrates that the degree of comorbidity symptoms is at least aggravated by enuresis (and/or high nocturnal diuresis rate) since sleep and (neuro)psychological functioning were significantly ameliorated by treatment of enuresis. These results indicate that enuresis is not such a benign condition as has previously been assumed.
Keywords
Desmopressin, Children, Psychology, Periodic limb movements, Quality of life, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, DEFICIT HYPERACTIVITY DISORDER, PERIODIC LIMB MOVEMENTS, METAANALYSIS, DOPAMINE, HEALTHY, AROUSAL, QUALITY, URINARY, 1ST

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Chicago
Van Herzeele, Charlotte, Karlien Dhondt, Sanne Roels, Ann Raes, Piet Hoebeke, LUITZEN ALBERT GROEN, and Johan Vande Walle. 2016. “Desmopressin (melt) Therapy in Children with Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria Results in Improved Neuropsychological Functioning and Sleep.” Pediatric Nephrology 31 (9): 1477–1484.
APA
Van Herzeele, C., Dhondt, K., Roels, S., Raes, A., Hoebeke, P., GROEN, L. A., & Vande Walle, J. (2016). Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep. PEDIATRIC NEPHROLOGY, 31(9), 1477–1484.
Vancouver
1.
Van Herzeele C, Dhondt K, Roels S, Raes A, Hoebeke P, GROEN LA, et al. Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep. PEDIATRIC NEPHROLOGY. 2016;31(9):1477–84.
MLA
Van Herzeele, Charlotte, Karlien Dhondt, Sanne Roels, et al. “Desmopressin (melt) Therapy in Children with Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria Results in Improved Neuropsychological Functioning and Sleep.” PEDIATRIC NEPHROLOGY 31.9 (2016): 1477–1484. Print.
@article{7224054,
  abstract     = {There is a high comorbidity between nocturnal enuresis, sleep disorders and psychological problems. The aim of this study was to investigate whether a decrease in nocturnal diuresis volume not only improves enuresis but also ameliorates disrupted sleep and (neuro)psychological dysfunction, the major comorbidities of this disorder. 
In this open-label, prospective phase IV study, 30 children with monosymptomatic nocturnal enuresis (MNE) underwent standardized video-polysomnographic testing and multi-informant (neuro)psychological testing at baseline and 6 months after the start of desmopressin treatment in the University Hospital Ghent, Belgium. Primary endpoints were the effect on sleep and (neuro)psychological functioning. The secondary endpoint was the change in the first undisturbed sleep period or the time to the first void. 
Thirty children aged between 6 and 16 (mean 10.43, standard deviation 3.08) years completed the study. The results demonstrated a significant decrease in periodic limb movements during sleep (PLMS) and a prolonged first undisturbed sleep period. Additionally, (neuro)psychological functioning was improved on several domains. 
The study demonstrates that the degree of comorbidity symptoms is at least aggravated by enuresis (and/or high nocturnal diuresis rate) since sleep and (neuro)psychological functioning were significantly ameliorated by treatment of enuresis. These results indicate that enuresis is not such a benign condition as has previously been assumed.},
  author       = {Van Herzeele, Charlotte and Dhondt, Karlien and Roels, Sanne and Raes, Ann and Hoebeke, Piet and GROEN, LUITZEN ALBERT and Vande Walle, Johan},
  issn         = {0931-041X},
  journal      = {PEDIATRIC NEPHROLOGY},
  language     = {eng},
  number       = {9},
  pages        = {1477--1484},
  title        = {Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep},
  url          = {http://dx.doi.org/10.1007/s00467-016-3351-3},
  volume       = {31},
  year         = {2016},
}

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