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Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers

Eliza Depoorter UGent, Matt J Bull, Charlotte Peeters UGent, Tom Coenye UGent, Peter Vandamme UGent and Eshwar Mahenthiralingam (2016) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 100(12). p.5215-5229
abstract
Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over 80 species have been formally named and multiple other genotypic groups likely represent new species. Phylogenetic analysis based on the 16S rRNA gene sequence and core genome ribosomal multilocus sequence typing analysis indicates the presence of at least three major clades within the genus. Biotechnologically, Burkholderia are well-known for their bioremediation and biopesticidal properties. Within this review, we explore the ability of Burkholderia to synthesise a wide range of antimicrobial compounds ranging from historically characterised antifungals to recently described antibacterial antibiotics with activity against multiresistant clinical pathogens. The production of multiple Burkholderia antibiotics is controlled by quorum sensing and examples of quorum sensing pathways found across the genus are discussed. The capacity for antibiotic biosynthesis and secondary metabolism encoded within Burkholderia genomes is also evaluated. Overall, Burkholderia demonstrate significant biotechnological potential as a source of novel antibiotics and bioactive secondary metabolites.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Burkholderia, Taxonomy, Phylogeny, Genomics, Secondary metabolism, Antibiotic biosynthesis, QUORUM-SENSING SYSTEM, PARATHION-DEGRADING BACTERIUM, BIOSYNTHETIC GENE CLUSTERS, RICE SEEDLING BLIGHT, SP NOV., CEPACIA COMPLEX, PSEUDOMONAS-CEPACIA, BIOLOGICAL-CONTROL, PYRROLNITRIN PRODUCTION, RHIZOPUS-MICROSPORUS
journal title
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Appl. Microbiol. Biotechnol.
volume
100
issue
12
pages
5215 - 5229
Web of Science type
Review
Web of Science id
000376456700003
JCR category
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
JCR impact factor
3.42 (2016)
JCR rank
43/158 (2016)
JCR quartile
2 (2016)
ISSN
0175-7598
DOI
10.1007/s00253-016-7520-x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7223815
handle
http://hdl.handle.net/1854/LU-7223815
date created
2016-05-23 13:58:32
date last changed
2017-08-03 10:59:51
@article{7223815,
  abstract     = {Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over 80 species have been formally named and multiple other genotypic groups likely represent new species. Phylogenetic analysis based on the 16S rRNA gene sequence and core genome ribosomal multilocus sequence typing analysis indicates the presence of at least three major clades within the genus. Biotechnologically, Burkholderia are well-known for their bioremediation and biopesticidal properties. Within this review, we explore the ability of Burkholderia to synthesise a wide range of antimicrobial compounds ranging from historically characterised antifungals to recently described antibacterial antibiotics with activity against multiresistant clinical pathogens. The production of multiple Burkholderia antibiotics is controlled by quorum sensing and examples of quorum sensing pathways found across the genus are discussed. The capacity for antibiotic biosynthesis and secondary metabolism encoded within Burkholderia genomes is also evaluated. Overall, Burkholderia demonstrate significant biotechnological potential as a source of novel antibiotics and bioactive secondary metabolites.},
  author       = {Depoorter, Eliza and Bull, Matt J and Peeters, Charlotte and Coenye, Tom and Vandamme, Peter and Mahenthiralingam, Eshwar},
  issn         = {0175-7598},
  journal      = {APPLIED MICROBIOLOGY AND BIOTECHNOLOGY},
  keyword      = {Burkholderia,Taxonomy,Phylogeny,Genomics,Secondary metabolism,Antibiotic biosynthesis,QUORUM-SENSING SYSTEM,PARATHION-DEGRADING BACTERIUM,BIOSYNTHETIC GENE CLUSTERS,RICE SEEDLING BLIGHT,SP NOV.,CEPACIA COMPLEX,PSEUDOMONAS-CEPACIA,BIOLOGICAL-CONTROL,PYRROLNITRIN PRODUCTION,RHIZOPUS-MICROSPORUS},
  language     = {eng},
  number       = {12},
  pages        = {5215--5229},
  title        = {Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers},
  url          = {http://dx.doi.org/10.1007/s00253-016-7520-x},
  volume       = {100},
  year         = {2016},
}

Chicago
Depoorter, Eliza, Matt J Bull, Charlotte Peeters, Tom Coenye, Peter Vandamme, and Eshwar Mahenthiralingam. 2016. “Burkholderia : an Update on Taxonomy and Biotechnological Potential as Antibiotic Producers.” Applied Microbiology and Biotechnology 100 (12): 5215–5229.
APA
Depoorter, E., Bull, M. J., Peeters, C., Coenye, T., Vandamme, P., & Mahenthiralingam, E. (2016). Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 100(12), 5215–5229.
Vancouver
1.
Depoorter E, Bull MJ, Peeters C, Coenye T, Vandamme P, Mahenthiralingam E. Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2016;100(12):5215–29.
MLA
Depoorter, Eliza, Matt J Bull, Charlotte Peeters, et al. “Burkholderia : an Update on Taxonomy and Biotechnological Potential as Antibiotic Producers.” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 100.12 (2016): 5215–5229. Print.