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Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers

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Abstract
Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over 80 species have been formally named and multiple other genotypic groups likely represent new species. Phylogenetic analysis based on the 16S rRNA gene sequence and core genome ribosomal multilocus sequence typing analysis indicates the presence of at least three major clades within the genus. Biotechnologically, Burkholderia are well-known for their bioremediation and biopesticidal properties. Within this review, we explore the ability of Burkholderia to synthesise a wide range of antimicrobial compounds ranging from historically characterised antifungals to recently described antibacterial antibiotics with activity against multiresistant clinical pathogens. The production of multiple Burkholderia antibiotics is controlled by quorum sensing and examples of quorum sensing pathways found across the genus are discussed. The capacity for antibiotic biosynthesis and secondary metabolism encoded within Burkholderia genomes is also evaluated. Overall, Burkholderia demonstrate significant biotechnological potential as a source of novel antibiotics and bioactive secondary metabolites.
Keywords
Burkholderia, Taxonomy, Phylogeny, Genomics, Secondary metabolism, Antibiotic biosynthesis, QUORUM-SENSING SYSTEM, PARATHION-DEGRADING BACTERIUM, BIOSYNTHETIC GENE CLUSTERS, RICE SEEDLING BLIGHT, SP NOV., CEPACIA COMPLEX, PSEUDOMONAS-CEPACIA, BIOLOGICAL-CONTROL, PYRROLNITRIN PRODUCTION, RHIZOPUS-MICROSPORUS

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Chicago
Depoorter, Eliza, Matt J Bull, Charlotte Peeters, Tom Coenye, Peter Vandamme, and Eshwar Mahenthiralingam. 2016. “Burkholderia : an Update on Taxonomy and Biotechnological Potential as Antibiotic Producers.” Applied Microbiology and Biotechnology 100 (12): 5215–5229.
APA
Depoorter, E., Bull, M. J., Peeters, C., Coenye, T., Vandamme, P., & Mahenthiralingam, E. (2016). Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 100(12), 5215–5229.
Vancouver
1.
Depoorter E, Bull MJ, Peeters C, Coenye T, Vandamme P, Mahenthiralingam E. Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2016;100(12):5215–29.
MLA
Depoorter, Eliza, Matt J Bull, Charlotte Peeters, et al. “Burkholderia : an Update on Taxonomy and Biotechnological Potential as Antibiotic Producers.” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 100.12 (2016): 5215–5229. Print.
@article{7223815,
  abstract     = {Burkholderia is an incredibly diverse and versatile Gram-negative genus, within which over 80 species have been formally named and multiple other genotypic groups likely represent new species. Phylogenetic analysis based on the 16S rRNA gene sequence and core genome ribosomal multilocus sequence typing analysis indicates the presence of at least three major clades within the genus. Biotechnologically, Burkholderia are well-known for their bioremediation and biopesticidal properties. Within this review, we explore the ability of Burkholderia to synthesise a wide range of antimicrobial compounds ranging from historically characterised antifungals to recently described antibacterial antibiotics with activity against multiresistant clinical pathogens. The production of multiple Burkholderia antibiotics is controlled by quorum sensing and examples of quorum sensing pathways found across the genus are discussed. The capacity for antibiotic biosynthesis and secondary metabolism encoded within Burkholderia genomes is also evaluated. Overall, Burkholderia demonstrate significant biotechnological potential as a source of novel antibiotics and bioactive secondary metabolites.},
  author       = {Depoorter, Eliza and Bull, Matt J and Peeters, Charlotte and Coenye, Tom and Vandamme, Peter and Mahenthiralingam, Eshwar},
  issn         = {0175-7598},
  journal      = {APPLIED MICROBIOLOGY AND BIOTECHNOLOGY},
  keyword      = {Burkholderia,Taxonomy,Phylogeny,Genomics,Secondary metabolism,Antibiotic biosynthesis,QUORUM-SENSING SYSTEM,PARATHION-DEGRADING BACTERIUM,BIOSYNTHETIC GENE CLUSTERS,RICE SEEDLING BLIGHT,SP NOV.,CEPACIA COMPLEX,PSEUDOMONAS-CEPACIA,BIOLOGICAL-CONTROL,PYRROLNITRIN PRODUCTION,RHIZOPUS-MICROSPORUS},
  language     = {eng},
  number       = {12},
  pages        = {5215--5229},
  title        = {Burkholderia : an update on taxonomy and biotechnological potential as antibiotic producers},
  url          = {http://dx.doi.org/10.1007/s00253-016-7520-x},
  volume       = {100},
  year         = {2016},
}

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