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Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love Aaes (UGent) , Agnieszka Kaczmarek (UGent) , Tinneke Delvaeye (UGent) , Bram De Craene (UGent) , Stefaan De Koker (UGent) , Liesbeth Heyndrickx (UGent) , Iris Delrue (UGent) , Joachim Taminau (UGent) , Bartosz Wiernicki (UGent) , Philippe De Groote (UGent) , et al.
(2016) CELL REPORTS. 15(2). p.274-287
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Abstract
Successful immunogenic apoptosis in experimental cancer therapy depends on the induction of strong host anti-tumor responses. Given that tumors are often resistant to apoptosis, it is important to identify alternative molecular mechanisms that elicit immunogenic cell death. We have developed a genetic model in which direct dimerization of FADD combined with inducible expression of RIPK3 promotes necroptosis. We report that necroptotic cancer cells release damage-associated molecular patterns and promote maturation of dendritic cells, the cross-priming of cytotoxic T cells, and the production of IFN-gamma in response to tumor antigen stimulation. Using both FADD-dependent and FADD-independent RIPK3 induction systems, we demonstrate the efficient vaccination potential of immunogenic necroptotic cells. Our study broadens the current concept of immunogenic cell death and opens doors for the development of new strategies in cancer therapy.
Keywords
CALRETICULIN EXPOSURE, PROGRAMMED NECROSIS, DOMAIN-LIKE PROTEIN, MIXED LINEAGE KINASE, ANTICANCER CHEMOTHERAPY, DEPENDENT APOPTOSIS, MOLECULAR-PATTERNS, RIP3 KINASE, DEATH, THERAPY

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MLA
Aaes, Tania Love et al. “Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.” CELL REPORTS 15.2 (2016): 274–287. Print.
APA
Aaes, T. L., Kaczmarek, A., Delvaeye, T., De Craene, B., De Koker, S., Heyndrickx, L., Delrue, I., et al. (2016). Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity. CELL REPORTS, 15(2), 274–287.
Chicago author-date
Aaes, Tania Love, Agnieszka Kaczmarek, Tinneke Delvaeye, Bram De Craene, Stefaan De Koker, Liesbeth Heyndrickx, Iris Delrue, et al. 2016. “Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.” Cell Reports 15 (2): 274–287.
Chicago author-date (all authors)
Aaes, Tania Love, Agnieszka Kaczmarek, Tinneke Delvaeye, Bram De Craene, Stefaan De Koker, Liesbeth Heyndrickx, Iris Delrue, Joachim Taminau, Bartosz Wiernicki, Philippe De Groote, Abhishek D Garg, Luc Leybaert, Johan Grooten, Mathieu Bertrand, Patrizia Agostinis, Geert Berx, Wim Declercq, Peter Vandenabeele, and Dmitri Krysko. 2016. “Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.” Cell Reports 15 (2): 274–287.
Vancouver
1.
Aaes TL, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity. CELL REPORTS. 2016;15(2):274–87.
IEEE
[1]
T. L. Aaes et al., “Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity,” CELL REPORTS, vol. 15, no. 2, pp. 274–287, 2016.
@article{7222408,
  abstract     = {Successful immunogenic apoptosis in experimental cancer therapy depends on the induction of strong host anti-tumor responses. Given that tumors are often resistant to apoptosis, it is important to identify alternative molecular mechanisms that elicit immunogenic cell death. We have developed a genetic model in which direct dimerization of FADD combined with inducible expression of RIPK3 promotes necroptosis. We report that necroptotic cancer cells release damage-associated molecular patterns and promote maturation of dendritic cells, the cross-priming of cytotoxic T cells, and the production of IFN-gamma in response to tumor antigen stimulation. Using both FADD-dependent and FADD-independent RIPK3 induction systems, we demonstrate the efficient vaccination potential of immunogenic necroptotic cells. Our study broadens the current concept of immunogenic cell death and opens doors for the development of new strategies in cancer therapy.},
  author       = {Aaes, Tania Love and Kaczmarek, Agnieszka and Delvaeye, Tinneke and De Craene, Bram and De Koker, Stefaan and Heyndrickx, Liesbeth and Delrue, Iris and Taminau, Joachim and Wiernicki, Bartosz and De Groote, Philippe and Garg,  Abhishek D and Leybaert, Luc and Grooten, Johan and Bertrand, Mathieu and Agostinis, Patrizia and Berx, Geert and Declercq, Wim and Vandenabeele, Peter and Krysko, Dmitri},
  issn         = {2211-1247},
  journal      = {CELL REPORTS},
  keywords     = {CALRETICULIN EXPOSURE,PROGRAMMED NECROSIS,DOMAIN-LIKE PROTEIN,MIXED LINEAGE KINASE,ANTICANCER CHEMOTHERAPY,DEPENDENT APOPTOSIS,MOLECULAR-PATTERNS,RIP3 KINASE,DEATH,THERAPY},
  language     = {eng},
  number       = {2},
  pages        = {274--287},
  title        = {Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity},
  url          = {http://dx.doi.org/10.1016/j.celrep.2016.03.037},
  volume       = {15},
  year         = {2016},
}

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