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Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter

Jozef Mravec UGent, Petr Skupa, Aurélien Bailly, Klára Hoyerová, Pavel Krecek, Agnieszka Bielach UGent, Jan Petrásek, Jing Zhang UGent, Vassilena Gaykova and York-Dieter Stierhof, et al. (2009) Nature. 459(7250). p.1136-1140
abstract
The plant signalling molecule auxin provides positional information in a variety of developmental processes by means of its differential distribution (gradients) within plant tissues(1). Thus, cellular auxin levels often determine the developmental output of auxin signalling. Conceptually, transmembrane transport and metabolic processes regulate the steady-state levels of auxin in any given cell(2,3). In particular, PIN auxin-efflux-carrier-mediated, directional transport between cells is crucial for generating auxin gradients(2,4,5). Here we show that Arabidopsis thaliana PIN5, an atypical member of the PIN gene family, encodes a functional auxin transporter that is required for auxin-mediated development. PIN5 does not have a direct role in cell-to-cell transport but regulates intracellular auxin homeostasis and metabolism. PIN5 localizes, unlike other characterized plasma membrane PIN proteins, to endoplasmic reticulum ( ER), presumably mediating auxin flow from the cytosol to the lumen of the ER. The ER localization of other PIN5-like transporters ( including the moss PIN) indicates that the diversification of PIN protein functions in mediating auxin homeostasis at the ER, and cell-to-cell auxin transport at the plasma membrane, represent an ancient event during the evolution of land plants.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EFFLUX, GRADIENTS, ARABIDOPSIS, TWISTED DWARF1, PLASMA-MEMBRANE, PLANT TRANSFORMATION, BOX PROTEIN TIR1, RECEPTOR, LAND, FLOW
journal title
Nature
Nature
volume
459
issue
7250
pages
1136 - 1140
Web of Science type
Article
Web of Science id
000267636700045
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
34.48 (2009)
JCR rank
1/48 (2009)
JCR quartile
1 (2009)
ISSN
0028-0836
DOI
10.1038/nature08066
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
721933
handle
http://hdl.handle.net/1854/LU-721933
date created
2009-08-04 20:39:04
date last changed
2009-08-05 15:56:09
@article{721933,
  abstract     = {The plant signalling molecule auxin provides positional information in a variety of developmental processes by means of its differential distribution (gradients) within plant tissues(1). Thus, cellular auxin levels often determine the developmental output of auxin signalling. Conceptually, transmembrane transport and metabolic processes regulate the steady-state levels of auxin in any given cell(2,3). In particular, PIN auxin-efflux-carrier-mediated, directional transport between cells is crucial for generating auxin gradients(2,4,5). Here we show that Arabidopsis thaliana PIN5, an atypical member of the PIN gene family, encodes a functional auxin transporter that is required for auxin-mediated development. PIN5 does not have a direct role in cell-to-cell transport but regulates intracellular auxin homeostasis and metabolism. PIN5 localizes, unlike other characterized plasma membrane PIN proteins, to endoplasmic reticulum ( ER), presumably mediating auxin flow from the cytosol to the lumen of the ER. The ER localization of other PIN5-like transporters ( including the moss PIN) indicates that the diversification of PIN protein functions in mediating auxin homeostasis at the ER, and cell-to-cell auxin transport at the plasma membrane, represent an ancient event during the evolution of land plants.},
  author       = {Mravec, Jozef and Skupa, Petr and Bailly, Aur{\'e}lien and Hoyerov{\'a}, Kl{\'a}ra and Krecek, Pavel and Bielach, Agnieszka and Petr{\'a}sek, Jan and Zhang, Jing and Gaykova, Vassilena and Stierhof, York-Dieter and Dobrev, Petre and Schwarzerov{\'a}, Katerina and Rolc{\'i}k, Jakub and Seifertov{\'a}, Daniela and Luschnig, Christian and Benkova, Eva and Zazimalov{\'a}, Eva and Geisler, Markus and Friml, Jiri},
  issn         = {0028-0836},
  journal      = {Nature},
  keyword      = {EFFLUX,GRADIENTS,ARABIDOPSIS,TWISTED DWARF1,PLASMA-MEMBRANE,PLANT TRANSFORMATION,BOX PROTEIN TIR1,RECEPTOR,LAND,FLOW},
  language     = {eng},
  number       = {7250},
  pages        = {1136--1140},
  title        = {Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter},
  url          = {http://dx.doi.org/10.1038/nature08066},
  volume       = {459},
  year         = {2009},
}

Chicago
Mravec, Jozef, Petr Skupa, Aurélien Bailly, Klára Hoyerová, Pavel Krecek, Agnieszka Bielach, Jan Petrásek, et al. 2009. “Subcellular Homeostasis of Phytohormone Auxin Is Mediated by the ER-localized PIN5 Transporter.” Nature 459 (7250): 1136–1140.
APA
Mravec, J., Skupa, P., Bailly, A., Hoyerová, K., Krecek, P., Bielach, A., Petrásek, J., et al. (2009). Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. Nature, 459(7250), 1136–1140.
Vancouver
1.
Mravec J, Skupa P, Bailly A, Hoyerová K, Krecek P, Bielach A, et al. Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. Nature. 2009;459(7250):1136–40.
MLA
Mravec, Jozef, Petr Skupa, Aurélien Bailly, et al. “Subcellular Homeostasis of Phytohormone Auxin Is Mediated by the ER-localized PIN5 Transporter.” Nature 459.7250 (2009): 1136–1140. Print.