Ghent University Academic Bibliography

Advanced

APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root

Marleen Vanstraelen UGent, Mikhail Baloban, Olivier Da Ines, Antonietta Cultrone, Tim Lammens UGent, Véronique Boudolf UGent, Spencer Brown, Lieven De Veylder UGent, Peter Mergaert UGent and Eva Kondorosi (2009) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106(28). p.11806-11811
abstract
Plant organs originate from meristems where stem cells are maintained to produce continuously daughter cells that are the source of different cell types. The cell cycle switch gene CCS52A, a substrate specific activator of the anaphase promoting complex/cyclosome (APC/C), controls the mitotic arrest and the transition of mitotic cycles to endoreduplication (ER) cycles as part of cell differentiation. Arabidopsis, unlike other organisms, contains 2 CCS52A isoforms. Here, we show that both of them are active and regulate meristem maintenance in the root tip, although through different mechanisms. The CCS52A1 activity in the elongation zone of the root stimulates ER and mitotic exit, and contributes to the border delineation between dividing and expanding cells. In contrast, CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance. Cell proliferation assays in roots suggest that this control involves CCS52A2 mediated repression of mitotic activity in the QC cells. The data indicate that the CCS52A genes favor a low mitotic state in different cell types of the root tip that is required for meristem maintenance, and reveal a previously undescribed mechanism for APC/C mediated control in plant development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
LOCALIZATION, ORGANIZATION, ACTIVATOR, ENDOREDUPLICATION, DROSOPHILA, CDC27 HOMOLOG, DIFFERENTIATION, RETINOBLASTOMA PROTEIN, PLANT-CELL CYCLE, ANAPHASE-PROMOTING COMPLEX, stem cells, cell differentiation, endoreduplication, CDH1, quiescent center
journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proc. Natl. Acad. Sci. USA
volume
106
issue
28
pages
11806 - 11811
Web of Science type
Article
Web of Science id
000267972700069
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
9.432 (2009)
JCR rank
3/48 (2009)
JCR quartile
1 (2009)
ISSN
0027-8424
DOI
10.1073/pnas.0901193106
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
721922
handle
http://hdl.handle.net/1854/LU-721922
date created
2009-08-04 20:24:32
date last changed
2013-10-16 11:45:16
@article{721922,
  abstract     = {Plant organs originate from meristems where stem cells are maintained to produce continuously daughter cells that are the source of different cell types. The cell cycle switch gene CCS52A, a substrate specific activator of the anaphase promoting complex/cyclosome (APC/C), controls the mitotic arrest and the transition of mitotic cycles to endoreduplication (ER) cycles as part of cell differentiation. Arabidopsis, unlike other organisms, contains 2 CCS52A isoforms. Here, we show that both of them are active and regulate meristem maintenance in the root tip, although through different mechanisms. The CCS52A1 activity in the elongation zone of the root stimulates ER and mitotic exit, and contributes to the border delineation between dividing and expanding cells. In contrast, CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance. Cell proliferation assays in roots suggest that this control involves CCS52A2 mediated repression of mitotic activity in the QC cells. The data indicate that the CCS52A genes favor a low mitotic state in different cell types of the root tip that is required for meristem maintenance, and reveal a previously undescribed mechanism for APC/C mediated control in plant development.},
  author       = {Vanstraelen, Marleen and Baloban, Mikhail and Da Ines, Olivier and Cultrone, Antonietta and Lammens, Tim and Boudolf, V{\'e}ronique and Brown, Spencer and De Veylder, Lieven and Mergaert, Peter and Kondorosi, Eva},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  keyword      = {LOCALIZATION,ORGANIZATION,ACTIVATOR,ENDOREDUPLICATION,DROSOPHILA,CDC27 HOMOLOG,DIFFERENTIATION,RETINOBLASTOMA PROTEIN,PLANT-CELL CYCLE,ANAPHASE-PROMOTING COMPLEX,stem cells,cell differentiation,endoreduplication,CDH1,quiescent center},
  language     = {eng},
  number       = {28},
  pages        = {11806--11811},
  title        = {APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root},
  url          = {http://dx.doi.org/10.1073/pnas.0901193106},
  volume       = {106},
  year         = {2009},
}

Chicago
Vanstraelen, Marleen, Mikhail Baloban, Olivier Da Ines, Antonietta Cultrone, Tim Lammens, Véronique Boudolf, Spencer Brown, Lieven De Veylder, Peter Mergaert, and Eva Kondorosi. 2009. “APC/C-CCS52A Complexes Control Meristem Maintenance in the Arabidopsis Root.” Proceedings of the National Academy of Sciences of the United States of America 106 (28): 11806–11811.
APA
Vanstraelen, M., Baloban, M., Da Ines, O., Cultrone, A., Lammens, T., Boudolf, V., Brown, S., et al. (2009). APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(28), 11806–11811.
Vancouver
1.
Vanstraelen M, Baloban M, Da Ines O, Cultrone A, Lammens T, Boudolf V, et al. APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(28):11806–11.
MLA
Vanstraelen, Marleen, Mikhail Baloban, Olivier Da Ines, et al. “APC/C-CCS52A Complexes Control Meristem Maintenance in the Arabidopsis Root.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.28 (2009): 11806–11811. Print.