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β-Glucan exacerbates allergic airway responses to house dust mite allergen

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Abstract
beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.
Keywords
RECOGNITION, IMMUNITY, ASTHMA, CELLS, IL-13, RECEPTOR, House dust mite, T helper 2, Eosinophil, Allergy, beta-glucans

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Citation

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Chicago
Hadebe, Sabelo, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I Murray, David L Williams, Bart Lambrecht, Frank Brombacher, and Gordon D Brown. 2016. “β-Glucan Exacerbates Allergic Airway Responses to House Dust Mite Allergen.” Respiratory Research 17.
APA
Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., Lambrecht, B., et al. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. RESPIRATORY RESEARCH, 17.
Vancouver
1.
Hadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray GI, Williams DL, et al. β-Glucan exacerbates allergic airway responses to house dust mite allergen. RESPIRATORY RESEARCH. 2016;17.
MLA
Hadebe, Sabelo et al. “β-Glucan Exacerbates Allergic Airway Responses to House Dust Mite Allergen.” RESPIRATORY RESEARCH 17 (2016): n. pag. Print.
@article{7215759,
  abstract     = {beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.},
  articleno    = {35},
  author       = {Hadebe, Sabelo and Kirstein, Frank and Fierens, Kaat and Redelinghuys, Pierre and Murray, Graeme I and Williams, David L and Lambrecht, Bart and Brombacher, Frank and Brown, Gordon D},
  issn         = {1465-993X},
  journal      = {RESPIRATORY RESEARCH},
  keywords     = {RECOGNITION,IMMUNITY,ASTHMA,CELLS,IL-13,RECEPTOR,House dust mite,T helper 2,Eosinophil,Allergy,beta-glucans},
  language     = {eng},
  pages        = {3},
  title        = {β-Glucan exacerbates allergic airway responses to house dust mite allergen},
  url          = {http://dx.doi.org/10.1186/s12931-016-0352-5},
  volume       = {17},
  year         = {2016},
}

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