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Vagus nerve stimulation applied with a rapid cycle has more profound influence on hippocampal electrophysiology than a standard cycle

Lars Larsen (UGent) , Wytse Wadman (UGent) , Daniele Marinazzo (UGent) , Pieter van Mierlo (UGent) , Jean Delbeke (UGent) , Sofie Daelemans (UGent) , Mathieu Sprengers (UGent) , Lisa Thyrion (UGent) , Wouter Van Lysebettens (UGent) , Evelien Carrette (UGent) , et al.
(2016) NEUROTHERAPEUTICS. 13(3). p.592-602
Author
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS. Rapid-cycle VNS had a greater effect than standard-cycle VNS on all outcome measures. Using rapid cycle VNS, a maximal effect on EEG parameters was found at 300 μA, beyond which effects saturated. The findings suggest that rapid-cycle VNS produces a more robust outcome than standard cycle VNS and support already existing preclinical evidence that relatively low output currents are sufficient to produce changes in brain physiology and thus likely also therapeutic efficacy.
Keywords
Stimulation parameters, Dentate gyrus, Phase amplitude coupling, Vagus nerve stimulation, EEG, Evoked potential, FREELY-MOVING RATS, DEVICE PARAMETERS, LONG-TERM, OSCILLATIONS, MEMORY, EXCITABILITY, PERFORMANCE, DEPRESSION, EPILEPSY, EFFICACY

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Citation

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Chicago
Larsen, Lars, Wytse Wadman, Daniele Marinazzo, Pieter van Mierlo, Jean Delbeke, Sofie Daelemans, Mathieu Sprengers, et al. 2016. “Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.” Neurotherapeutics 13 (3): 592–602.
APA
Larsen, L., Wadman, W., Marinazzo, D., van Mierlo, P., Delbeke, J., Daelemans, S., Sprengers, M., et al. (2016). Vagus nerve stimulation applied with a rapid cycle has more profound influence on hippocampal electrophysiology than a standard cycle. NEUROTHERAPEUTICS, 13(3), 592–602.
Vancouver
1.
Larsen L, Wadman W, Marinazzo D, van Mierlo P, Delbeke J, Daelemans S, et al. Vagus nerve stimulation applied with a rapid cycle has more profound influence on hippocampal electrophysiology than a standard cycle. NEUROTHERAPEUTICS. 2016;13(3):592–602.
MLA
Larsen, Lars, Wytse Wadman, Daniele Marinazzo, et al. “Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.” NEUROTHERAPEUTICS 13.3 (2016): 592–602. Print.
@article{7207338,
  abstract     = {Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS. Rapid-cycle VNS had a greater effect than standard-cycle VNS on all outcome measures. Using rapid cycle VNS, a maximal effect on EEG parameters was found at 300 \ensuremath{\mu}A, beyond which effects saturated. The findings suggest that rapid-cycle VNS produces a more robust outcome than standard cycle VNS and support already existing preclinical evidence that relatively low output currents are sufficient to produce changes in brain physiology and thus likely also therapeutic efficacy.},
  author       = {Larsen, Lars and Wadman, Wytse and Marinazzo, Daniele and van Mierlo, Pieter and Delbeke, Jean and Daelemans, Sofie and Sprengers, Mathieu and Thyrion, Lisa and Van Lysebettens, Wouter and Carrette, Evelien and Boon, Paul and Vonck, Kristl and Raedt, Robrecht},
  issn         = {1933-7213},
  journal      = {NEUROTHERAPEUTICS},
  keyword      = {Stimulation parameters,Dentate gyrus,Phase amplitude coupling,Vagus nerve stimulation,EEG,Evoked potential,FREELY-MOVING RATS,DEVICE PARAMETERS,LONG-TERM,OSCILLATIONS,MEMORY,EXCITABILITY,PERFORMANCE,DEPRESSION,EPILEPSY,EFFICACY},
  language     = {eng},
  number       = {3},
  pages        = {592--602},
  title        = {Vagus nerve stimulation applied with a rapid cycle has more profound influence on hippocampal electrophysiology than a standard cycle},
  url          = {http://dx.doi.org/10.1007/s13311-016-0432-8},
  volume       = {13},
  year         = {2016},
}

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