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Influence of mycotoxin binders on the oral bioavailability of doxycycline in pigs

Thomas De Mil (UGent) , Mathias Devreese (UGent) , Sarah De Saeger (UGent) , Mia Eeckhout (UGent) , Patrick De Backer (UGent) and Siska Croubels (UGent)
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Abstract
Mycotoxin binders are feed additives that aim to adsorb mycotoxins in the gastrointestinal tract of animals, making them unavailable for systemic absorption. The antimicrobial drug doxycycline (DOX) is often used in pigs and is administered through feed or drinking water; hence, DOX can come in contact with mycotoxin binders in the gastrointestinal tract. This paper describes the effect of four mycotoxin binders on the absorption of orally administered DOX in pigs. Two experiments were conducted: The first used a setup with bolus administration to fasted pigs at two different dosages of mycotoxin binder. In the second experiment, DOX and the binders were mixed in the feed at dosages recommended by the manufacturers (= field conditions). Interactions are possible between some of the mycotoxin binders dosed at 10 g/kg feed but not at 2 g/kg feed. When applying field conditions, no influences were seen on the plasma concentrations of DOX.

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Chicago
De Mil, Thomas, Mathias Devreese, Sarah De Saeger, Mia Eeckhout, Patrick De Backer, and Siska Croubels. 2016. “Influence of Mycotoxin Binders on the Oral Bioavailability of Doxycycline in Pigs.” In Mycotoxin Workshop, 38th, Abstract Book.
APA
De Mil, Thomas, Devreese, M., De Saeger, S., Eeckhout, M., De Backer, P., & Croubels, S. (2016). Influence of mycotoxin binders on the oral bioavailability of doxycycline in pigs. Mycotoxin workshop, 38th, Abstract book. Presented at the 38th Mycotoxin workshop.
Vancouver
1.
De Mil T, Devreese M, De Saeger S, Eeckhout M, De Backer P, Croubels S. Influence of mycotoxin binders on the oral bioavailability of doxycycline in pigs. Mycotoxin workshop, 38th, Abstract book. 2016.
MLA
De Mil, Thomas et al. “Influence of Mycotoxin Binders on the Oral Bioavailability of Doxycycline in Pigs.” Mycotoxin Workshop, 38th, Abstract Book. 2016. Print.
@inproceedings{7205299,
  abstract     = {Mycotoxin binders are feed additives that aim to adsorb mycotoxins in the gastrointestinal tract of animals, making them unavailable for systemic absorption. The antimicrobial drug doxycycline (DOX) is often used in pigs and is administered through feed or drinking water; hence, DOX can come in contact with mycotoxin binders in the gastrointestinal
tract. This paper describes the effect of four mycotoxin binders on the absorption of orally administered DOX in pigs. Two experiments were conducted: The first used a setup with bolus administration to fasted pigs at two different dosages of mycotoxin binder. In the second experiment, DOX and the binders were mixed in the feed at dosages recommended by the manufacturers (= field conditions). Interactions are possible between some of the mycotoxin binders dosed at 10 g/kg feed but not at 2 g/kg feed. When applying field conditions, no influences were seen on the plasma concentrations of DOX.},
  author       = {De Mil, Thomas and Devreese, Mathias and De Saeger, Sarah and Eeckhout, Mia and De Backer, Patrick and Croubels, Siska},
  booktitle    = {Mycotoxin workshop, 38th, Abstract book},
  language     = {eng},
  location     = {Berlin, Germany},
  title        = {Influence of mycotoxin binders on the oral bioavailability of doxycycline in pigs},
  year         = {2016},
}