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Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men

Stefanie De Buyser UGent, Mirko Petrovic UGent, Youri Taes, Kaatje Toye UGent, Jean Kaufman UGent, Bruno Lapauw UGent and Stefan Goemaere (2016) AGE AND AGEING. 45(5). p.603-609
abstract
Objective: we aimed to evaluate the Foundation for the National Institutes of Health (FNIH) criteria for weakness and low muscle mass and the Study of Osteoporotic Fractures (SOF) frailty index for prediction of long-term, all-cause mortality. Design: community-based cohort study. Setting: semi-rural community of Merelbeke (Belgium). Subjects: ambulatory men aged 74 and more (n = 191). Methods: weakness was defined on previously established criteria as low grip strength (<26 kg) or low grip strength-to-body mass index (BMI) ratio (<1.00). Low muscle mass (dual-energy x-ray absorptiometry) was categorised as low appendicular lean mass (ALM; predefined <19.75 kg) or low ALM-to-BMI ratio ( predefined <0.789). Frailty status was assessed using the components of weight loss, inability to rise from a chair and poor energy (SOF index). Survival time was calculated as the number of months from assessment in 2000 until death or up to 15 years of follow-up. Results: mean age of the participants was 78.4 ± 3.5 years. Combined weakness and low muscle mass was present in 3–8% of men, depending on the criteria applied. Pre-frailty and frailty were present in 30 and 7% of men, respectively. After 15 years of follow-up, 165 men (86%) died. Both the presence of combined weakness and low ALM-to-BMI ratio (age-adjusted HR = 2.50, 95% CI = 1.30–4.79) and the presence of SOF frailty (age-adjusted HR = 2.64, 95% CI = 1.44–4.86) were associated with mortality. Conclusions: our findings confirm the predictive value for mortality of the non-distribution-based FNIH criteria and SOF index in older community-dwelling Belgian men.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ambulatory older men, SOF frailty, mortality, FNIH sarcopenia, CLINICALLY RELEVANT WEAKNESS, LEAN MASS, DISABILITY, FRACTURES, PROJECT, HEALTH, ADULTS, FALLS, PREVALENCE, CUTPOINTS
journal title
AGE AND AGEING
Age Ageing
editor
David Stott
volume
45
issue
5
pages
603 - 609
Web of Science type
Article
Web of Science id
000384648500009
JCR category
GERIATRICS & GERONTOLOGY
JCR impact factor
4.282 (2016)
JCR rank
9/49 (2016)
JCR quartile
1 (2016)
ISSN
0002-0729
DOI
10.1093/ageing/afw071
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7203879
handle
http://hdl.handle.net/1854/LU-7203879
date created
2016-05-03 12:44:30
date last changed
2017-04-24 11:02:40
@article{7203879,
  abstract     = {Objective: we aimed to evaluate the Foundation for the National Institutes of Health (FNIH) criteria for weakness and low muscle mass and the Study of Osteoporotic Fractures (SOF) frailty index for prediction of long-term, all-cause mortality.
Design: community-based cohort study.
Setting: semi-rural community of Merelbeke (Belgium).
Subjects: ambulatory men aged 74 and more (n = 191).
Methods: weakness was defined on previously established criteria as low grip strength ({\textlangle}26 kg) or low grip strength-to-body mass index (BMI) ratio ({\textlangle}1.00). Low muscle mass (dual-energy x-ray absorptiometry) was categorised as low appendicular lean mass (ALM; predefined {\textlangle}19.75 kg) or low ALM-to-BMI ratio ( predefined {\textlangle}0.789). Frailty status was assessed using the components of weight loss, inability to rise from a chair and poor energy (SOF index). Survival time was calculated as the number of months from assessment in 2000 until death or up to 15 years of follow-up.
Results: mean age of the participants was 78.4 {\textpm} 3.5 years. Combined weakness and low muscle mass was present in 3--8\% of men, depending on the criteria applied. Pre-frailty and frailty were present in 30 and 7\% of men, respectively. After 15 years of follow-up, 165 men (86\%) died. Both the presence of combined weakness and low ALM-to-BMI ratio (age-adjusted HR = 2.50, 95\% CI = 1.30--4.79) and the presence of SOF frailty (age-adjusted HR = 2.64, 95\% CI = 1.44--4.86) were associated with mortality.
Conclusions: our findings confirm the predictive value for mortality of the non-distribution-based FNIH criteria and SOF index in older community-dwelling Belgian men.},
  author       = {De Buyser, Stefanie and Petrovic, Mirko and Taes, Youri and Toye, Kaatje and Kaufman, Jean and Lapauw, Bruno and Goemaere, Stefan},
  editor       = {Stott, David},
  issn         = {0002-0729},
  journal      = {AGE AND AGEING},
  keyword      = {ambulatory older men,SOF frailty,mortality,FNIH sarcopenia,CLINICALLY RELEVANT WEAKNESS,LEAN MASS,DISABILITY,FRACTURES,PROJECT,HEALTH,ADULTS,FALLS,PREVALENCE,CUTPOINTS},
  language     = {eng},
  number       = {5},
  pages        = {603--609},
  title        = {Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men},
  url          = {http://dx.doi.org/10.1093/ageing/afw071},
  volume       = {45},
  year         = {2016},
}

Chicago
De Buyser, Stefanie, Mirko Petrovic, Youri Taes, Kaatje Toye, Jean Kaufman, Bruno Lapauw, and STEFAN GOEMAERE. 2016. “Validation of the FNIH Sarcopenia Criteria and SOF Frailty Index as Predictors of Long-term Mortality in Ambulatory Older Men.” Ed. David Stott. Age and Ageing 45 (5): 603–609.
APA
De Buyser, S., Petrovic, M., Taes, Y., Toye, K., Kaufman, J., Lapauw, B., & GOEMAERE, S. (2016). Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. (D. Stott, Ed.)AGE AND AGEING, 45(5), 603–609.
Vancouver
1.
De Buyser S, Petrovic M, Taes Y, Toye K, Kaufman J, Lapauw B, et al. Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. Stott D, editor. AGE AND AGEING. 2016;45(5):603–9.
MLA
De Buyser, Stefanie, Mirko Petrovic, Youri Taes, et al. “Validation of the FNIH Sarcopenia Criteria and SOF Frailty Index as Predictors of Long-term Mortality in Ambulatory Older Men.” Ed. David Stott. AGE AND AGEING 45.5 (2016): 603–609. Print.