Advanced search
1 file | 249.67 KB Add to list

Effectiveness of folic acid fortified flour for prevention of neural tube defects in a high risk region

(2016) NUTRIENTS. 8(3).
Author
Organization
Abstract
Despite efforts to tackle folate deficiency and Neural Tube Defects (NTDs) through folic acid fortification, its implementation is still lacking where it is needed most, highlighting the need for studies that evaluate the effectiveness of folic acid fortified wheat flour in a poor, rural, high-risk, NTD region of China. One of the most affected regions, Shanxi Province, was selected as a case study. A community intervention was carried out in which 16,648 women of child-bearing age received fortified flour (eight villages) and a control group received ordinary flour (three villages). NTD birth prevalence and biological indicators were measured two years after program initiation at endline only. The effect on the NTD burden was calculated using the disability-adjusted life years (DALYs) method. In the intervention group, serum folate level was higher than in the control group. NTDs in the intervention group were 68.2% lower than in the control group (OR = 0.313, 95% CI = 0.207-0473, p < 0.001). In terms of DALYs, burden in intervention group was approximately 58.5% lower than in the control group. Flour fortification was associated with lower birth prevalence and burden of NTDs in economically developing regions with a high risk of NTDs. The positive findings confirm the potential of fortification when selecting an appropriate food vehicle and target region. As such, this study provides support for decision makers aiming for the implementation of (mandatory) folic acid fortification in China.
Keywords
community intervention, neural tube defects, China, folic acid fortified flour, DALY, COST-EFFECTIVENESS, SHANXI PROVINCE, HIGH-PREVALENCE, BIRTH-DEFECTS, UNITED-STATES, FOOD FORTIFICATION, BIOFORTIFIED RICE, NORTHERN CHINA, NEW-ZEALAND, SUPPLEMENTATION

Downloads

  • De Steur Hans Effectiveness nutrients-08-00152.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 249.67 KB

Citation

Please use this url to cite or link to this publication:

MLA
Wang, Haochen et al. “Effectiveness of Folic Acid Fortified Flour for Prevention of Neural Tube Defects in a High Risk Region.” NUTRIENTS 8.3 (2016): n. pag. Print.
APA
Wang, Haochen, De Steur, H., Chen, G., Zhang, X., Pei, L., Gellynck, X., & Zheng, X. (2016). Effectiveness of folic acid fortified flour for prevention of neural tube defects in a high risk region. NUTRIENTS, 8(3).
Chicago author-date
Wang, Haochen, Hans De Steur, Gong Chen, Xiaotian Zhang, Lijun Pei, Xavier Gellynck, and Xiaoying Zheng. 2016. “Effectiveness of Folic Acid Fortified Flour for Prevention of Neural Tube Defects in a High Risk Region.” Nutrients 8 (3).
Chicago author-date (all authors)
Wang, Haochen, Hans De Steur, Gong Chen, Xiaotian Zhang, Lijun Pei, Xavier Gellynck, and Xiaoying Zheng. 2016. “Effectiveness of Folic Acid Fortified Flour for Prevention of Neural Tube Defects in a High Risk Region.” Nutrients 8 (3).
Vancouver
1.
Wang H, De Steur H, Chen G, Zhang X, Pei L, Gellynck X, et al. Effectiveness of folic acid fortified flour for prevention of neural tube defects in a high risk region. NUTRIENTS. 2016;8(3).
IEEE
[1]
H. Wang et al., “Effectiveness of folic acid fortified flour for prevention of neural tube defects in a high risk region,” NUTRIENTS, vol. 8, no. 3, 2016.
@article{7203117,
  abstract     = {Despite efforts to tackle folate deficiency and Neural Tube Defects (NTDs) through folic acid fortification, its implementation is still lacking where it is needed most, highlighting the need for studies that evaluate the effectiveness of folic acid fortified wheat flour in a poor, rural, high-risk, NTD region of China. One of the most affected regions, Shanxi Province, was selected as a case study. A community intervention was carried out in which 16,648 women of child-bearing age received fortified flour (eight villages) and a control group received ordinary flour (three villages). NTD birth prevalence and biological indicators were measured two years after program initiation at endline only. The effect on the NTD burden was calculated using the disability-adjusted life years (DALYs) method. In the intervention group, serum folate level was higher than in the control group. NTDs in the intervention group were 68.2% lower than in the control group (OR = 0.313, 95% CI = 0.207-0473, p < 0.001). In terms of DALYs, burden in intervention group was approximately 58.5% lower than in the control group. Flour fortification was associated with lower birth prevalence and burden of NTDs in economically developing regions with a high risk of NTDs. The positive findings confirm the potential of fortification when selecting an appropriate food vehicle and target region. As such, this study provides support for decision makers aiming for the implementation of (mandatory) folic acid fortification in China.},
  articleno    = {152},
  author       = {Wang, Haochen and De Steur, Hans and Chen, Gong and Zhang, Xiaotian and Pei, Lijun and Gellynck, Xavier and Zheng, Xiaoying},
  issn         = {2072-6643},
  journal      = {NUTRIENTS},
  keywords     = {community intervention,neural tube defects,China,folic acid fortified flour,DALY,COST-EFFECTIVENESS,SHANXI PROVINCE,HIGH-PREVALENCE,BIRTH-DEFECTS,UNITED-STATES,FOOD FORTIFICATION,BIOFORTIFIED RICE,NORTHERN CHINA,NEW-ZEALAND,SUPPLEMENTATION},
  language     = {eng},
  number       = {3},
  pages        = {11},
  title        = {Effectiveness of folic acid fortified flour for prevention of neural tube defects in a high risk region},
  url          = {http://dx.doi.org/10.3390/nu8030152},
  volume       = {8},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: