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Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD : a systematic review

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Abstract
Patients with COPD suffer from lower-limb muscle dysfunction characterized by lower muscle oxidative capacity and muscle mass. Exercise-based training is expected to attenuate lower-limb intramuscular characteristics, but a detailed systematic approach to review the available evidence has not been performed yet. PUBMED and PEDro databases were searched. Twenty-five studies that implemented an exercise-based training program (aerobic and/or resistance training, high intensity interval training, electrical or magnetic stimulation) and reported muscle biopsy data of patients with COPD were critically appraised. The coverage of results includes changes in muscle structure, muscle protein turnover regulation, mitochondrial enzyme activity, oxidative and nitrosative stress, and inflammation after exercise-based training interventions. Study design and training modalities varied among studies, which partly explains the observed heterogeneous response in muscle characteristics. Gaps in the current knowledge are identified and recommendations for future research are made to enhance our knowledge on exercise training effects in patients with COPD.
Keywords
skeletal muscle, vastus lateralis, quadriceps muscle, pulmonary rehabilitation, muscle morphology, muscle biopsy, COPD, exercise training, OBSTRUCTIVE PULMONARY-DISEASE, CHRONIC HEART-FAILURE, NEUROMUSCULAR ELECTRICAL-STIMULATION, GROWTH-FACTOR-I, VASTUS LATERALIS MUSCLE, UNTRAINED OLDER MEN, SPINAL-CORD-INJURY, SKELETAL-MUSCLE, IGF-I, OXIDATIVE CAPACITY

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MLA
De Brandt, Jana et al. “Changes in Structural and Metabolic Muscle Characteristics Following Exercise-based Interventions in Patients with COPD : a Systematic Review.” EXPERT REVIEW OF RESPIRATORY MEDICINE 10.5 (2016): 521–545. Print.
APA
De Brandt, J., Spruit, M., Derave, W., Hansen, D., Vanfleteren, L. E., & Burtin, C. (2016). Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD : a systematic review. EXPERT REVIEW OF RESPIRATORY MEDICINE, 10(5), 521–545.
Chicago author-date
De Brandt, Jana, Martijn Spruit, Wim Derave, Dominique Hansen, Lowie EGW Vanfleteren, and Chris Burtin. 2016. “Changes in Structural and Metabolic Muscle Characteristics Following Exercise-based Interventions in Patients with COPD : a Systematic Review.” Expert Review of Respiratory Medicine 10 (5): 521–545.
Chicago author-date (all authors)
De Brandt, Jana, Martijn Spruit, Wim Derave, Dominique Hansen, Lowie EGW Vanfleteren, and Chris Burtin. 2016. “Changes in Structural and Metabolic Muscle Characteristics Following Exercise-based Interventions in Patients with COPD : a Systematic Review.” Expert Review of Respiratory Medicine 10 (5): 521–545.
Vancouver
1.
De Brandt J, Spruit M, Derave W, Hansen D, Vanfleteren LE, Burtin C. Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD : a systematic review. EXPERT REVIEW OF RESPIRATORY MEDICINE. 2016;10(5):521–45.
IEEE
[1]
J. De Brandt, M. Spruit, W. Derave, D. Hansen, L. E. Vanfleteren, and C. Burtin, “Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD : a systematic review,” EXPERT REVIEW OF RESPIRATORY MEDICINE, vol. 10, no. 5, pp. 521–545, 2016.
@article{7195452,
  abstract     = {Patients with COPD suffer from lower-limb muscle dysfunction characterized by lower muscle oxidative capacity and muscle mass. Exercise-based training is expected to attenuate lower-limb intramuscular characteristics, but a detailed systematic approach to review the available evidence has not been performed yet. PUBMED and PEDro databases were searched. Twenty-five studies that implemented an exercise-based training program (aerobic and/or resistance training, high intensity interval training, electrical or magnetic stimulation) and reported muscle biopsy data of patients with COPD were critically appraised. The coverage of results includes changes in muscle structure, muscle protein turnover regulation, mitochondrial enzyme activity, oxidative and nitrosative stress, and inflammation after exercise-based training interventions. Study design and training modalities varied among studies, which partly explains the observed heterogeneous response in muscle characteristics. Gaps in the current knowledge are identified and recommendations for future research are made to enhance our knowledge on exercise training effects in patients with COPD.},
  author       = {De Brandt, Jana and Spruit, Martijn and Derave, Wim and Hansen, Dominique and Vanfleteren, Lowie EGW and Burtin, Chris},
  issn         = {1747-6348},
  journal      = {EXPERT REVIEW OF RESPIRATORY MEDICINE},
  keywords     = {skeletal muscle,vastus lateralis,quadriceps muscle,pulmonary rehabilitation,muscle morphology,muscle biopsy,COPD,exercise training,OBSTRUCTIVE PULMONARY-DISEASE,CHRONIC HEART-FAILURE,NEUROMUSCULAR ELECTRICAL-STIMULATION,GROWTH-FACTOR-I,VASTUS LATERALIS MUSCLE,UNTRAINED OLDER MEN,SPINAL-CORD-INJURY,SKELETAL-MUSCLE,IGF-I,OXIDATIVE CAPACITY},
  language     = {eng},
  number       = {5},
  pages        = {521--545},
  title        = {Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD : a systematic review},
  url          = {http://dx.doi.org/10.1586/17476348.2016.1157472},
  volume       = {10},
  year         = {2016},
}

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