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Exploration of the medicinal peptide space

(2016) PROTEIN AND PEPTIDE LETTERS. 23(4). p.324-335
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Abstract
The chemical properties of peptide medicines, known as the ‘medicinal peptide space’ is considered a multi-dimensional subset of the global peptide space, where each dimension represents a chemical descriptor. These descriptors can be linked to biofunctional, medicinal properties to varying degrees. Knowledge of this space can increase the efficiency of the peptide-drug discovery and development process, as well as advance our understanding and classification of peptide medicines. For 245 peptide drugs, already available on the market or in clinical development, multivariate data-exploration was performed using peptide relevant physicochemical descriptors, their specific peptide-drug target and their clinical use. Our retrospective analysis indicates that clusters in the medicinal peptide space are located in a relatively narrow range of the physicochemical space: dense and empty regions were found, which can be explored for the discovery of novel peptide drugs.
Keywords
drug market, peptide therapeutics, drug discovery, Chemical space, PCA, PHASE-II TRIAL, PERCUTANEOUS CORONARY INTERVENTION, ELEVATION MYOCARDIAL-INFARCTION, NK2 RECEPTOR ANTAGONIST, ADVANCED SOLID TUMORS, DOUBLE-BLIND, CLINICAL-TRIAL, NATRIURETIC PEPTIDE, REPERFUSION INJURY, INSULIN-SECRETION

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Citation

Please use this url to cite or link to this publication:

MLA
Gevaert, Bert et al. “Exploration of the Medicinal Peptide Space.” PROTEIN AND PEPTIDE LETTERS 23.4 (2016): 324–335. Print.
APA
Gevaert, B., Stalmans, S., Wynendaele, E., Taevernier, L., Bracke, N., D’Hondt, M., & De Spiegeleer, B. (2016). Exploration of the medicinal peptide space. PROTEIN AND PEPTIDE LETTERS, 23(4), 324–335.
Chicago author-date
Gevaert, Bert, Sofie Stalmans, Evelien Wynendaele, Lien Taevernier, Nathalie Bracke, Matthias D’Hondt, and Bart De Spiegeleer. 2016. “Exploration of the Medicinal Peptide Space.” Protein and Peptide Letters 23 (4): 324–335.
Chicago author-date (all authors)
Gevaert, Bert, Sofie Stalmans, Evelien Wynendaele, Lien Taevernier, Nathalie Bracke, Matthias D’Hondt, and Bart De Spiegeleer. 2016. “Exploration of the Medicinal Peptide Space.” Protein and Peptide Letters 23 (4): 324–335.
Vancouver
1.
Gevaert B, Stalmans S, Wynendaele E, Taevernier L, Bracke N, D’Hondt M, et al. Exploration of the medicinal peptide space. PROTEIN AND PEPTIDE LETTERS. 2016;23(4):324–35.
IEEE
[1]
B. Gevaert et al., “Exploration of the medicinal peptide space,” PROTEIN AND PEPTIDE LETTERS, vol. 23, no. 4, pp. 324–335, 2016.
@article{7191229,
  abstract     = {The chemical properties of peptide medicines, known as the ‘medicinal peptide space’ is considered a multi-dimensional subset of the global peptide space, where each dimension represents a chemical descriptor. These descriptors can be linked to biofunctional, medicinal properties to varying degrees. Knowledge of this space can increase the efficiency of the peptide-drug discovery and development process, as well as advance our understanding and classification of peptide medicines.
For 245 peptide drugs, already available on the market or in clinical development, multivariate data-exploration was performed using peptide relevant physicochemical descriptors, their specific peptide-drug target and their clinical use. Our retrospective analysis indicates that clusters in the medicinal peptide space are located in a relatively narrow range of the physicochemical space: dense and empty regions were found, which can be explored for the discovery of novel peptide drugs.},
  author       = {Gevaert, Bert and Stalmans, Sofie and Wynendaele, Evelien and Taevernier, Lien and Bracke, Nathalie and D'Hondt, Matthias and De Spiegeleer, Bart},
  issn         = {0929-8665},
  journal      = {PROTEIN AND PEPTIDE LETTERS},
  keywords     = {drug market,peptide therapeutics,drug discovery,Chemical space,PCA,PHASE-II TRIAL,PERCUTANEOUS CORONARY INTERVENTION,ELEVATION MYOCARDIAL-INFARCTION,NK2 RECEPTOR ANTAGONIST,ADVANCED SOLID TUMORS,DOUBLE-BLIND,CLINICAL-TRIAL,NATRIURETIC PEPTIDE,REPERFUSION INJURY,INSULIN-SECRETION},
  language     = {eng},
  number       = {4},
  pages        = {324--335},
  title        = {Exploration of the medicinal peptide space},
  url          = {http://dx.doi.org/10.2174/0929866523666160215162326},
  volume       = {23},
  year         = {2016},
}

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