Buruli ulcer: a review of in vitro tests to screen natural products for activity against Mycobacterium ulcerans
- Author
- Achille Yemoa, Joachim Gbenou, Dissou Affolabi, Mansourou Moudachirou, Andre Bigot, Severin Anagonou, Françoise Portaels, Joelle Quetin-Leclercq and Anandi Martin (UGent)
- Organization
- Abstract
- Buruli ulcer (BU), caused by Mycobacterium ulcerans, has recently been recognized by the World Health Organization (WHO) as an important emerging disease. It is largely a problem of the poor in remote rural areas and has emerged as an important cause of human suffering. While antimycobacterial therapy is often effective for the earliest nodular or ulcerative lesions, for advanced ulcerated lesions, surgery is sometimes necessary. Antimycobacterial drugs may also prevent relapses or disseminated infections. Efficient alternatives different from surgery are presently explored because this treatment deals with huge restrictive factors such as the necessity of pro-longed hospitalization, its high cost, and the scars after surgery. Traditional treatment remains the first option for poor populations of remote areas who may have problems of accessibility to synthetic products because of their high cost. The search for efficient natural products active on M. ulcerans should then be encouraged because they are part of the natural heritage of these populations; they are affordable financially and can be used at the earliest stage. This review provides a number of tests that will help to evaluate the antimycobacterial activity of natural products against M. ulcerans, which are adapted to its slow growing rate, and lists active extracts published up to now in Medline.
- Keywords
- antimycobacterial, natural products, screening, Buruli ulcer, MICROTITER ASSAY PLATE, ALAMAR BLUE ASSAY, ANTIMICROBIAL ACTIVITY, INEXPENSIVE METHOD, RAPID DETECTION, TUBERCULOSIS, SUSCEPTIBILITY, SYSTEM, RESISTANCE, EXTRACTS
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-7187326
- MLA
- Yemoa, Achille, et al. “Buruli Ulcer: A Review of in Vitro Tests to Screen Natural Products for Activity against Mycobacterium Ulcerans.” PLANTA MEDICA, vol. 77, no. 6, 2011, pp. 641–46, doi:10.1055/s-0030-1250642.
- APA
- Yemoa, A., Gbenou, J., Affolabi, D., Moudachirou, M., Bigot, A., Anagonou, S., … Martin, A. (2011). Buruli ulcer: a review of in vitro tests to screen natural products for activity against Mycobacterium ulcerans. PLANTA MEDICA, 77(6), 641–646. https://doi.org/10.1055/s-0030-1250642
- Chicago author-date
- Yemoa, Achille, Joachim Gbenou, Dissou Affolabi, Mansourou Moudachirou, Andre Bigot, Severin Anagonou, Françoise Portaels, Joelle Quetin-Leclercq, and Anandi Martin. 2011. “Buruli Ulcer: A Review of in Vitro Tests to Screen Natural Products for Activity against Mycobacterium Ulcerans.” PLANTA MEDICA 77 (6): 641–46. https://doi.org/10.1055/s-0030-1250642.
- Chicago author-date (all authors)
- Yemoa, Achille, Joachim Gbenou, Dissou Affolabi, Mansourou Moudachirou, Andre Bigot, Severin Anagonou, Françoise Portaels, Joelle Quetin-Leclercq, and Anandi Martin. 2011. “Buruli Ulcer: A Review of in Vitro Tests to Screen Natural Products for Activity against Mycobacterium Ulcerans.” PLANTA MEDICA 77 (6): 641–646. doi:10.1055/s-0030-1250642.
- Vancouver
- 1.Yemoa A, Gbenou J, Affolabi D, Moudachirou M, Bigot A, Anagonou S, et al. Buruli ulcer: a review of in vitro tests to screen natural products for activity against Mycobacterium ulcerans. PLANTA MEDICA. 2011;77(6):641–6.
- IEEE
- [1]A. Yemoa et al., “Buruli ulcer: a review of in vitro tests to screen natural products for activity against Mycobacterium ulcerans,” PLANTA MEDICA, vol. 77, no. 6, pp. 641–646, 2011.
@article{7187326, abstract = {{Buruli ulcer (BU), caused by Mycobacterium ulcerans, has recently been recognized by the World Health Organization (WHO) as an important emerging disease. It is largely a problem of the poor in remote rural areas and has emerged as an important cause of human suffering. While antimycobacterial therapy is often effective for the earliest nodular or ulcerative lesions, for advanced ulcerated lesions, surgery is sometimes necessary. Antimycobacterial drugs may also prevent relapses or disseminated infections. Efficient alternatives different from surgery are presently explored because this treatment deals with huge restrictive factors such as the necessity of pro-longed hospitalization, its high cost, and the scars after surgery. Traditional treatment remains the first option for poor populations of remote areas who may have problems of accessibility to synthetic products because of their high cost. The search for efficient natural products active on M. ulcerans should then be encouraged because they are part of the natural heritage of these populations; they are affordable financially and can be used at the earliest stage. This review provides a number of tests that will help to evaluate the antimycobacterial activity of natural products against M. ulcerans, which are adapted to its slow growing rate, and lists active extracts published up to now in Medline.}}, author = {{Yemoa, Achille and Gbenou, Joachim and Affolabi, Dissou and Moudachirou, Mansourou and Bigot, Andre and Anagonou, Severin and Portaels, Françoise and Quetin-Leclercq, Joelle and Martin, Anandi}}, issn = {{0032-0943}}, journal = {{PLANTA MEDICA}}, keywords = {{antimycobacterial,natural products,screening,Buruli ulcer,MICROTITER ASSAY PLATE,ALAMAR BLUE ASSAY,ANTIMICROBIAL ACTIVITY,INEXPENSIVE METHOD,RAPID DETECTION,TUBERCULOSIS,SUSCEPTIBILITY,SYSTEM,RESISTANCE,EXTRACTS}}, language = {{eng}}, number = {{6}}, pages = {{641--646}}, title = {{Buruli ulcer: a review of in vitro tests to screen natural products for activity against Mycobacterium ulcerans}}, url = {{http://doi.org/10.1055/s-0030-1250642}}, volume = {{77}}, year = {{2011}}, }
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