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A redox signalling globin is essential for reproduction in Caenorhabditis elegans

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Abstract
Moderate levels of reactive oxygen species (ROS) are now recognized as redox signalling molecules. However, thus far, only mitochondria and NADPH oxidases have been identified as cellular sources of ROS in signalling. Here we identify a globin (GLB-12) that produces superoxide, a type of ROS, which serves as an essential signal for reproduction in C. elegans. We find that GLB-12 has an important role in the regulation of multiple aspects in germline development, including germ cell apoptosis. We further describe how GLB-12 displays specific molecular, biochemical and structural properties that allow this globin to act as a superoxide generator. In addition, both an intra-and extracellular superoxide dismutase act as key partners of GLB-12 to create a transmembrane redox signal. Our results show that a globin can function as a driving factor in redox signalling, and how this signal is regulated at the subcellular level by multiple control layers.
Keywords
HYDROGEN-PEROXIDE, HEART CYTOCHROME-C, CRYSTAL-STRUCTURE, ROS HOMEOSTASIS, EXPRESSION, NEUROGLOBIN, HEMOGLOBIN, STRESS, APOPTOSIS, MEMBRANES

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MLA
De Henau, Sasha et al. “A Redox Signalling Globin Is Essential for Reproduction in Caenorhabditis Elegans.” NATURE COMMUNICATIONS 6 (2015): n. pag. Print.
APA
De Henau, S., Tilleman, L., Vangheel, M., Luyckx, E., Trashin, S., Pauwels, M., Germani, F., et al. (2015). A redox signalling globin is essential for reproduction in Caenorhabditis elegans. NATURE COMMUNICATIONS, 6.
Chicago author-date
De Henau, Sasha, Lesley Tilleman, Matthew Vangheel, Evi Luyckx, Stanislav Trashin, Martje Pauwels, Francesca Germani, et al. 2015. “A Redox Signalling Globin Is Essential for Reproduction in Caenorhabditis Elegans.” Nature Communications 6.
Chicago author-date (all authors)
De Henau, Sasha, Lesley Tilleman, Matthew Vangheel, Evi Luyckx, Stanislav Trashin, Martje Pauwels, Francesca Germani, Caroline Vlaeminck, Jacques Vanfleteren, Wim Bert, Alessandra Pesce, Marco Nardini, Martino Bolognesi, Karolien De Wael, Luc Moens, Sylvia Dewilde, and Bart Braeckman. 2015. “A Redox Signalling Globin Is Essential for Reproduction in Caenorhabditis Elegans.” Nature Communications 6.
Vancouver
1.
De Henau S, Tilleman L, Vangheel M, Luyckx E, Trashin S, Pauwels M, et al. A redox signalling globin is essential for reproduction in Caenorhabditis elegans. NATURE COMMUNICATIONS. 2015;6.
IEEE
[1]
S. De Henau et al., “A redox signalling globin is essential for reproduction in Caenorhabditis elegans,” NATURE COMMUNICATIONS, vol. 6, 2015.
@article{7177259,
  abstract     = {Moderate levels of reactive oxygen species (ROS) are now recognized as redox signalling molecules. However, thus far, only mitochondria and NADPH oxidases have been identified as cellular sources of ROS in signalling. Here we identify a globin (GLB-12) that produces superoxide, a type of ROS, which serves as an essential signal for reproduction in C. elegans. We find that GLB-12 has an important role in the regulation of multiple aspects in germline development, including germ cell apoptosis. We further describe how GLB-12 displays specific molecular, biochemical and structural properties that allow this globin to act as a superoxide generator. In addition, both an intra-and extracellular superoxide dismutase act as key partners of GLB-12 to create a transmembrane redox signal. Our results show that a globin can function as a driving factor in redox signalling, and how this signal is regulated at the subcellular level by multiple control layers.},
  articleno    = {8782},
  author       = {De Henau, Sasha and Tilleman, Lesley and Vangheel, Matthew and Luyckx, Evi and Trashin, Stanislav and Pauwels, Martje and Germani, Francesca and Vlaeminck, Caroline and Vanfleteren, Jacques and Bert, Wim and Pesce, Alessandra and Nardini, Marco and Bolognesi, Martino and De Wael, Karolien and Moens, Luc and Dewilde, Sylvia and Braeckman, Bart},
  issn         = {2041-1723},
  journal      = {NATURE COMMUNICATIONS},
  keywords     = {HYDROGEN-PEROXIDE,HEART CYTOCHROME-C,CRYSTAL-STRUCTURE,ROS HOMEOSTASIS,EXPRESSION,NEUROGLOBIN,HEMOGLOBIN,STRESS,APOPTOSIS,MEMBRANES},
  language     = {eng},
  pages        = {14},
  title        = {A redox signalling globin is essential for reproduction in Caenorhabditis elegans},
  url          = {http://dx.doi.org/10.1038/ncomms9782},
  volume       = {6},
  year         = {2015},
}

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