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Sub-millimetre DOI detector based on monolithic LYSO and digital SiPM for a dedicated small-animal PET system

(2016) PHYSICS IN MEDICINE AND BIOLOGY. 61(5). p.2196-2212
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Abstract
The mouse model is widely used in a vast range of biomedical and preclinical studies. Thanks to the ability to detect and quantify biological processes at the molecular level in vivo, PET has become a well-established tool in these investigations. However, the need to visualize and quantify radiopharmaceuticals in anatomic structures of millimetre or less requires good spatial resolution and sensitivity from small-animal PET imaging systems. In previous work we have presented a proof-of-concept of a dedicated high- resolution small-animal PET scanner based on thin monolithic scintillator crystals and Digital Photon Counter photosensor. The combination of thin monolithic crystals and MLE positioning algorithm resulted in an excellent spatial resolution of 0.7mm uniform in the entire field of view (FOV). However, the limitation of the scanner was its low sensitivity due to small hickness of the LYSO crystals (2 mm). Here we present an improved detector design for a small-animal PET system that simultaneously achieves higher sensitivity and sustains a sub- millimetre spatial resolution. The proposed detector consists of a 5 mm thick monolithic LYSO crystal optically coupled to a Digital Photon Counter. Mean nearest neighbour (MNN) positioning combined with depth of interaction (DOI) decoding was employed to achieve sub-millimetre spatial resolution. To evaluate detector performance the intrinsic spatial resolution, energy resolution and coincidence resolving time (CRT) were measured. The average intrinsic spatial resolution of the detector was 0.60mm full-width-at-half- maximum (FWHM). A DOI resolution of 1.66 mm was achieved. The energy resolution was 23% FWHM at 511 keV and CRT of 529ps were measured. The improved detector design overcomes the sensitivity limitation of the previous design by increasing the nominal sensitivity of the detector block and retains an excellent intrinsic spatial resolution.
Keywords
preclinical, monolithic scintillators, small-animal, PET, digital silicon photomultiplier

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Chicago
Marcinkowski, Radoslaw, Pieter Mollet, Roel Van Holen, and Stefaan Vandenberghe. 2016. “Sub-millimetre DOI Detector Based on Monolithic LYSO and Digital SiPM for a Dedicated Small-animal PET System.” Physics in Medicine and Biology 61 (5): 2196–2212.
APA
Marcinkowski, R., Mollet, P., Van Holen, R., & Vandenberghe, S. (2016). Sub-millimetre DOI detector based on monolithic LYSO and digital SiPM for a dedicated small-animal PET system. PHYSICS IN MEDICINE AND BIOLOGY, 61(5), 2196–2212.
Vancouver
1.
Marcinkowski R, Mollet P, Van Holen R, Vandenberghe S. Sub-millimetre DOI detector based on monolithic LYSO and digital SiPM for a dedicated small-animal PET system. PHYSICS IN MEDICINE AND BIOLOGY. IOP Publishing | Institute of Physics and Engineering in Medicine; 2016;61(5):2196–212.
MLA
Marcinkowski, Radoslaw, Pieter Mollet, Roel Van Holen, et al. “Sub-millimetre DOI Detector Based on Monolithic LYSO and Digital SiPM for a Dedicated Small-animal PET System.” PHYSICS IN MEDICINE AND BIOLOGY 61.5 (2016): 2196–2212. Print.
@article{7175981,
  abstract     = {The mouse model is widely used in a vast range of biomedical and preclinical studies. Thanks to the ability to detect and quantify biological processes at the molecular level in vivo, PET has become a well-established tool in these investigations. However, the need to visualize and quantify radiopharmaceuticals in anatomic structures of millimetre or less requires good spatial resolution and sensitivity from small-animal PET imaging systems. In previous work we have presented a proof-of-concept of a dedicated high- resolution small-animal PET scanner based on thin monolithic scintillator crystals and Digital Photon Counter photosensor. The combination of thin monolithic crystals and MLE positioning algorithm resulted in an excellent spatial resolution of 0.7mm uniform in the entire field of view (FOV). However, the limitation of the scanner was its low sensitivity due to small hickness of the LYSO crystals (2 mm). Here we present an improved detector design for a small-animal PET system that simultaneously achieves higher sensitivity and sustains a sub- millimetre spatial resolution. The proposed detector consists of a 5 mm thick monolithic LYSO crystal optically coupled to a Digital Photon Counter. Mean nearest neighbour (MNN) positioning combined with depth of interaction (DOI) decoding was employed to achieve sub-millimetre spatial resolution. To evaluate detector performance the intrinsic spatial resolution, energy resolution and coincidence resolving time (CRT) were measured. The average intrinsic spatial resolution of the detector was 0.60mm full-width-at-half- maximum (FWHM). A DOI resolution of 1.66 mm was achieved. The energy resolution was 23\% FWHM at 511 keV and CRT of 529ps were measured. The improved detector design overcomes the sensitivity limitation of the previous design by increasing the nominal sensitivity of the detector block and retains an excellent intrinsic spatial resolution.},
  author       = {Marcinkowski, Radoslaw and Mollet, Pieter and Van Holen, Roel and Vandenberghe, Stefaan},
  issn         = {0031-9155},
  journal      = {PHYSICS IN MEDICINE AND BIOLOGY},
  keyword      = {preclinical,monolithic scintillators,small-animal,PET,digital silicon photomultiplier},
  language     = {eng},
  number       = {5},
  pages        = {2196--2212},
  publisher    = {IOP Publishing | Institute of Physics and Engineering in Medicine},
  title        = {Sub-millimetre DOI detector based on monolithic LYSO and digital SiPM for a dedicated small-animal PET system},
  url          = {http://dx.doi.org/10.1088/0031-9155/61/5/2196},
  volume       = {61},
  year         = {2016},
}

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