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M2e-based universal influenza A vaccines

Lei Deng (UGent) , Ki Joon Cho (UGent) , Walter Fiers and Xavier Saelens (UGent)
(2015) VACCINES. 3(1). p.105-136
Author
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Abstract
The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these vaccines needs to be updated nearly every year. Vaccines that target conserved epitopes of influenza viruses would in principle not require such updating and would probably have a considerable positive impact on global human health in case of a pandemic outbreak. The extracellular domain of Matrix 2 (M2e) protein is an evolutionarily conserved region in influenza A viruses and a promising epitope for designing a universal influenza vaccine. Here we review the seminal and recent studies that focused on M2e as a vaccine antigen. We address the mechanism of action and the clinical development of M2e-vaccines. Finally, we try to foresee how M2e-based vaccines could be implemented clinically in the future.
Keywords
influenza, matrix protein 2, vaccines, VIRUS M2 PROTEIN, HIGH EPITOPE DENSITY, CELLULAR IMMUNE-RESPONSES, HUMAN MONOCLONAL-ANTIBODY, MATRIX PROTEIN-2, PROTON CHANNEL, EXTRACELLULAR DOMAIN, SEASONAL INFLUENZA, PROTECTIVE IMMUNITY, FUSION PROTEIN

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Citation

Please use this url to cite or link to this publication:

MLA
Deng, Lei et al. “M2e-based Universal Influenza A Vaccines.” VACCINES 3.1 (2015): 105–136. Print.
APA
Deng, L., Cho, K. J., Fiers, W., & Saelens, X. (2015). M2e-based universal influenza A vaccines. VACCINES, 3(1), 105–136.
Chicago author-date
Deng, Lei, Ki Joon Cho, Walter Fiers, and Xavier Saelens. 2015. “M2e-based Universal Influenza A Vaccines.” Vaccines 3 (1): 105–136.
Chicago author-date (all authors)
Deng, Lei, Ki Joon Cho, Walter Fiers, and Xavier Saelens. 2015. “M2e-based Universal Influenza A Vaccines.” Vaccines 3 (1): 105–136.
Vancouver
1.
Deng L, Cho KJ, Fiers W, Saelens X. M2e-based universal influenza A vaccines. VACCINES. 2015;3(1):105–36.
IEEE
[1]
L. Deng, K. J. Cho, W. Fiers, and X. Saelens, “M2e-based universal influenza A vaccines,” VACCINES, vol. 3, no. 1, pp. 105–136, 2015.
@article{7175207,
  abstract     = {The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these vaccines needs to be updated nearly every year. Vaccines that target conserved epitopes of influenza viruses would in principle not require such updating and would probably have a considerable positive impact on global human health in case of a pandemic outbreak. The extracellular domain of Matrix 2 (M2e) protein is an evolutionarily conserved region in influenza A viruses and a promising epitope for designing a universal influenza vaccine. Here we review the seminal and recent studies that focused on M2e as a vaccine antigen. We address the mechanism of action and the clinical development of M2e-vaccines. Finally, we try to foresee how M2e-based vaccines could be implemented clinically in the future.},
  author       = {Deng, Lei and Cho, Ki Joon and Fiers, Walter and Saelens, Xavier},
  issn         = {2076-393X},
  journal      = {VACCINES},
  keywords     = {influenza,matrix protein 2,vaccines,VIRUS M2 PROTEIN,HIGH EPITOPE DENSITY,CELLULAR IMMUNE-RESPONSES,HUMAN MONOCLONAL-ANTIBODY,MATRIX PROTEIN-2,PROTON CHANNEL,EXTRACELLULAR DOMAIN,SEASONAL INFLUENZA,PROTECTIVE IMMUNITY,FUSION PROTEIN},
  language     = {eng},
  number       = {1},
  pages        = {105--136},
  title        = {M2e-based universal influenza A vaccines},
  url          = {http://dx.doi.org/10.3390/vaccines3010105},
  volume       = {3},
  year         = {2015},
}

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