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The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization

LIEN CALUS, LIEN DEVUYST, Thibaut Van Zele UGent, Natalie De Ruyck UGent, Lara Derycke UGent, Claus Bachert UGent and Philippe Gevaert UGent (2016) CLINICAL AND EXPERIMENTAL ALLERGY. 46(4). p.555-563
abstract
Background: The majority of grass pollen–sensitized rhinitis patients develops allergic symptoms when exposed to the causal allergen and shows a positive nasal allergen provocation test (NAPT). Chronic rhinosinusitis with nasal polyposis (CRSwNP) patients, also characterized by eosinophilic inflammation and local IgE production, can suffer from comorbid inhalant allergy, but may show a different response to allergens. Objective: We aimed to explore the allergic response to grass pollen allergens by NAPT in grass pollen–sensitized CRSwNP patients. Methods: Twelve grass pollen–sensitized CRSwNP patients underwent NAPT with grass pollen and were compared with 12 grass pollen allergic rhinitis patients, 12 control patients and 12 CRSwNP patients without grass pollen sensitization. A positive NAPT was based on change in nasal airflow and symptoms. Further, VAS scores of different symptoms were noted before and after NAPT. Biomarkers such as total IgE, grass pollen–specific IgE and tryptase were measured in serum and nasal secretions. Results: NAPT was positive in 6 of 12 of the grass pollen–sensitized CRSwNP patients, and another four patients developed allergic symptoms not fulfilling the criteria of positivity. In contrast, all patients with allergic rhinitis developed a positive provocation test, whereas in the control group one of the patients and in the non-sensitized CRSwNP group two of the patients developed a positive provocation test. Conclusion and clinical relevance: These results show that allergen exposure induces an attenuated clinical response in patients with CRSwNP and sensitization to grass pollen as compared with grass pollen allergic rhinitis patients.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
nasal polyp, MAST-CELLS, chronic rhinosinusitis with nasal polyposis, allergic rhinitis, IgE, nasal allergen provocation test, CLINICAL-IMMUNOLOGY, IGE, RHINITIS, TISSUE, ENTEROTOXINS, ORGANIZATION, EOSINOPHILS, DISEASES, SOCIETY
journal title
CLINICAL AND EXPERIMENTAL ALLERGY
Clin. Exp. Allergy
volume
46
issue
4
pages
555 - 563
Web of Science type
Article
Web of Science id
000373459800006
JCR category
ALLERGY
JCR impact factor
5.264 (2016)
JCR rank
4/26 (2016)
JCR quartile
1 (2016)
ISSN
0954-7894
DOI
10.1111/cea.12687
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to this article
copyright statement
I have transferred the copyright for this publication to the publisher
id
7172547
handle
http://hdl.handle.net/1854/LU-7172547
date created
2016-04-01 15:04:19
date last changed
2016-12-19 15:42:39
@article{7172547,
  abstract     = {Background: The majority of grass pollen--sensitized rhinitis patients develops allergic symptoms when exposed to the causal allergen and shows a positive nasal allergen provocation test (NAPT). Chronic rhinosinusitis with nasal polyposis (CRSwNP) patients, also characterized by eosinophilic inflammation and local IgE production, can suffer from comorbid inhalant allergy, but may show a different response to allergens.
Objective: We aimed to explore the allergic response to grass pollen allergens by NAPT in grass pollen--sensitized CRSwNP patients.
Methods: Twelve grass pollen--sensitized CRSwNP patients underwent NAPT with grass pollen and were compared with 12 grass pollen allergic rhinitis patients, 12 control patients and 12 CRSwNP patients without grass pollen sensitization. A positive NAPT was based on change in nasal airflow and symptoms. Further, VAS scores of different symptoms were noted before and after NAPT. Biomarkers such as total IgE, grass pollen--specific IgE and tryptase were measured in serum and nasal secretions.
Results: NAPT was positive in 6 of 12 of the grass pollen--sensitized CRSwNP patients, and another four patients developed allergic symptoms not fulfilling the criteria of positivity. In contrast, all patients with allergic rhinitis developed a positive provocation test, whereas in the control group one of the patients and in the non-sensitized CRSwNP group two of the patients developed a positive provocation test.
Conclusion and clinical relevance: These results show that allergen exposure induces an attenuated clinical response in patients with CRSwNP and sensitization to grass pollen as compared with grass pollen allergic rhinitis patients.},
  author       = {CALUS, LIEN and DEVUYST, LIEN and Van Zele, Thibaut and De Ruyck, Natalie and Derycke, Lara and Bachert, Claus and Gevaert, Philippe},
  issn         = {0954-7894},
  journal      = {CLINICAL AND EXPERIMENTAL ALLERGY},
  keyword      = {nasal polyp,MAST-CELLS,chronic rhinosinusitis with nasal polyposis,allergic rhinitis,IgE,nasal allergen provocation test,CLINICAL-IMMUNOLOGY,IGE,RHINITIS,TISSUE,ENTEROTOXINS,ORGANIZATION,EOSINOPHILS,DISEASES,SOCIETY},
  language     = {eng},
  number       = {4},
  pages        = {555--563},
  title        = {The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization},
  url          = {http://dx.doi.org/10.1111/cea.12687},
  volume       = {46},
  year         = {2016},
}

Chicago
CALUS, LIEN, LIEN DEVUYST, Thibaut Van Zele, Natalie De Ruyck, Lara Derycke, Claus Bachert, and Philippe Gevaert. 2016. “The Response to Nasal Allergen Provocation with Grass Pollen Is Reduced in Patients with Chronic Rhinosinusitis with Nasal Polyposis and Grass Sensitization.” Clinical and Experimental Allergy 46 (4): 555–563.
APA
CALUS, L., DEVUYST, L., Van Zele, T., De Ruyck, N., Derycke, L., Bachert, C., & Gevaert, P. (2016). The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization. CLINICAL AND EXPERIMENTAL ALLERGY, 46(4), 555–563.
Vancouver
1.
CALUS L, DEVUYST L, Van Zele T, De Ruyck N, Derycke L, Bachert C, et al. The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization. CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(4):555–63.
MLA
CALUS, LIEN, LIEN DEVUYST, Thibaut Van Zele, et al. “The Response to Nasal Allergen Provocation with Grass Pollen Is Reduced in Patients with Chronic Rhinosinusitis with Nasal Polyposis and Grass Sensitization.” CLINICAL AND EXPERIMENTAL ALLERGY 46.4 (2016): 555–563. Print.