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A simple dilute-and-shoot approach for the determination of ultra-trace levels of arsenic in biological fluids via ICP-MS using CH3F/He as a reaction gas

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Abstract
The performance of a mixture of CH3F/He (1/9) as a reaction gas for the determination of As in biological fluids using a quadrupole ICP-MS instrument has been explored. A simple (dilute-and-shoot) interference-free method has been developed to quantify As concentrations at trace and ultra-trace levels in matrices with a high Cl content. As+ reacts with CH3F (through CH3F addition, followed by HF elimination) with high efficiency forming AsCH2+ as the primary reaction product, which can be monitored at a mass-to-charge ratio of 89, free from the Cl-based interferents (e.g., (ArCl+)-Ar-40-Cl-35 and (CaCl+)-Ca-40-Cl-35) that hamper the monitoring of As-75(+). Matrix effects are overcome by the use of Te as an internal standard and the addition of 3% v/v ethanol to all samples and calibration standard solutions. The method presented was validated by analysing a set of reference materials (blood, serum and urine) and by assessing As recovery from a set of real blood samples. With this method, the limit of detection was calculated to be 0.8 ng L-1 As, favourably comparable to the vast majority of values reported in the literature, even with those obtained using more sophisticated sector-field instrumentation.
Keywords
ATOMIC TRANSITION-METAL, ION-MOLECULE REACTIONS, DYNAMIC REACTION CELL, PLASMA-MASS-SPECTROMETRY, MAIN-GROUP CATIONS, METHYL-FLUORIDE, SPECTRAL INTERFERENCES, SELENIUM, SAMPLES, SYSTEM

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Chicago
Florez Garcia, Maria del Rosario, E García-Ruiz, Eduardo Bolea Fernandez, Frank Vanhaecke, and Martín Resano. 2016. “A Simple Dilute-and-shoot Approach for the Determination of Ultra-trace Levels of Arsenic in Biological Fluids via ICP-MS Using CH3F/He as a Reaction Gas.” Journal of Analytical Atomic Spectrometry 31 (1): 245–251.
APA
Florez Garcia, M. del R., García-Ruiz, E., Bolea Fernandez, E., Vanhaecke, F., & Resano, M. (2016). A simple dilute-and-shoot approach for the determination of ultra-trace levels of arsenic in biological fluids via ICP-MS using CH3F/He as a reaction gas. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 31(1), 245–251.
Vancouver
1.
Florez Garcia M del R, García-Ruiz E, Bolea Fernandez E, Vanhaecke F, Resano M. A simple dilute-and-shoot approach for the determination of ultra-trace levels of arsenic in biological fluids via ICP-MS using CH3F/He as a reaction gas. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 2016;31(1):245–51.
MLA
Florez Garcia, Maria del Rosario, E García-Ruiz, Eduardo Bolea Fernandez, et al. “A Simple Dilute-and-shoot Approach for the Determination of Ultra-trace Levels of Arsenic in Biological Fluids via ICP-MS Using CH3F/He as a Reaction Gas.” JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 31.1 (2016): 245–251. Print.
@article{7171469,
  abstract     = {The performance of a mixture of CH3F/He (1/9) as a reaction gas for the determination of As in biological fluids using a quadrupole ICP-MS instrument has been explored. A simple (dilute-and-shoot) interference-free method has been developed to quantify As concentrations at trace and ultra-trace levels in matrices with a high Cl content. As+ reacts with CH3F (through CH3F addition, followed by HF elimination) with high efficiency forming AsCH2+ as the primary reaction product, which can be monitored at a mass-to-charge ratio of 89, free from the Cl-based interferents (e.g., (ArCl+)-Ar-40-Cl-35 and (CaCl+)-Ca-40-Cl-35) that hamper the monitoring of As-75(+). Matrix effects are overcome by the use of Te as an internal standard and the addition of 3\% v/v ethanol to all samples and calibration standard solutions. The method presented was validated by analysing a set of reference materials (blood, serum and urine) and by assessing As recovery from a set of real blood samples. With this method, the limit of detection was calculated to be 0.8 ng L-1 As, favourably comparable to the vast majority of values reported in the literature, even with those obtained using more sophisticated sector-field instrumentation.},
  author       = {Florez Garcia, Maria del Rosario and Garc{\'i}a-Ruiz, E and Bolea Fernandez, Eduardo and Vanhaecke, Frank and Resano, Mart{\'i}n},
  issn         = {0267-9477},
  journal      = {JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY},
  keyword      = {ATOMIC TRANSITION-METAL,ION-MOLECULE REACTIONS,DYNAMIC REACTION CELL,PLASMA-MASS-SPECTROMETRY,MAIN-GROUP CATIONS,METHYL-FLUORIDE,SPECTRAL INTERFERENCES,SELENIUM,SAMPLES,SYSTEM},
  language     = {eng},
  number       = {1},
  pages        = {245--251},
  title        = {A simple dilute-and-shoot approach for the determination of ultra-trace levels of arsenic in biological fluids via ICP-MS using CH3F/He as a reaction gas},
  url          = {http://dx.doi.org/10.1039/c5ja00298b},
  volume       = {31},
  year         = {2016},
}

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