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Addition of meloxicam to the treatment of clinical mastitis improves subsequent reproductive performance

S McDougall, E Abbeloos, Sofie Piepers UGent, AS Rao, S Astiz, T van Werven, J Statham and N Perez-Villalobos (2016) JOURNAL OF DAIRY SCIENCE. 99(3). p.2026-2042
abstract
A blinded, negative controlled, randomized intervention study was undertaken to test the hypothesis that addition of meloxicam, a nonsteroidal anti-inflammatory drug, to antimicrobial treatment of mild to moderate clinical mastitis would improve fertility and reduce the risk of removal from the herd. Cows (n = 509) from 61 herds in 8 regions (sites) in 6 European countries were enrolled. Following herd-owner diagnosis of mild to moderate clinical mastitis within the first 120 d of lactation in a single gland, the rectal temperature, milk appearance, and California Mastitis Test score were assessed. Cows were randomly assigned within each site to be treated either with meloxicam or a placebo (control). All cows were additionally treated with 1 to 4 intramammary infusions of cephalexin and kanamycin at 24-h intervals. Prior to treatment and at 14 and 21 d posttreatment, milk samples were collected for bacteriology and somatic cell count. Cows were bred by artificial insemination and pregnancy status was subsequently defined. General estimating equations were used to determine the effect of treatment (meloxicam versus control) on bacteriological cure, somatic cell count, the probability of being inseminated by 21 d after the voluntary waiting period, the probability of conception to first artificial insemination, the number of artificial insemination/conception, the probability of pregnancy by 120 or 200 d postcalving, and the risk of removal by 300 d after treatment. Cox's proportional hazards models were used to test the effect of treatment on the calving to first insemination and calving to conception intervals. Groups did not differ in terms of age, clot score, California Mastitis Test score, rectal temperature, number of antimicrobial treatments given or bacteria present at the time of enrollment, but cows treated with meloxicam had greater days in milk at enrollment. Cows treated with meloxicam had a higher bacteriological cure proportion than those treated with the placebo [0.66 (standard error = 0.04) versus 0.50 (standard error = 0.06), respectively], although the proportion of glands from which no bacteria were isolated posttreatment did not differ between groups. No difference was observed in the somatic cell count between groups pre- or posttreatment. The proportion of cows that underwent artificial insemination by 21 d after the voluntary waiting period was unaffected by treatment. Treatment with meloxicam was associated with a higher proportion of cows conceiving to their first artificial insemination (0.31 versus 0.21), and a higher proportion of meloxicam-treated cows were pregnant by 120 d after calving (0.40 versus 0.31). The number of artificial inseminations required to achieve conception was lower in the meloxicam compared with control cows (2.43 versus 2.92). No difference was observed between groups in the proportion of cows pregnant by 200 d after calving or in the proportion of cows that were culled, died, or sold by 300 d after calving (17% versus 21% for meloxicam versus control, respectively). It was concluded that use of meloxicam, in conjunction with antimicrobial therapy, for mild to moderate cases of clinical mastitis, resulted in a higher probability of bacteriological cure, an increased probability of conception to first artificial insemination, fewer artificial inseminations, and a greater proportion of cows pregnant by 120 d in milk.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HOLSTEIN DAIRY-COWS, SURVIVAL ANALYSIS, cure, fertility, mastitis, nonsteroidal anti-inflammatory drug, FLUNIXIN MEGLUMINE, EARLY LACTATION, FOLLICULAR FUNCTION, BODY-CONDITION SCORE, FINNISH AYRSHIRE COWS, FLIGHT MASS-SPECTROMETRY, NEW-YORK-STATE, ESCHERICHIA-COLI MASTITIS
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
99
issue
3
pages
2026 - 2042
Web of Science type
Article
Web of Science id
000370100600038
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
2.474 (2016)
JCR rank
3/58 (2016)
JCR quartile
1 (2016)
ISSN
0022-0302
DOI
10.3168/jds.2015-9615
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
7170566
handle
http://hdl.handle.net/1854/LU-7170566
date created
2016-03-31 13:20:04
date last changed
2017-03-22 13:57:28
@article{7170566,
  abstract     = {A blinded, negative controlled, randomized intervention study was undertaken to test the hypothesis that addition of meloxicam, a nonsteroidal anti-inflammatory drug, to antimicrobial treatment of mild to moderate clinical mastitis would improve fertility and reduce the risk of removal from the herd. Cows (n = 509) from 61 herds in 8 regions (sites) in 6 European countries were enrolled. Following herd-owner diagnosis of mild to moderate clinical mastitis within the first 120 d of lactation in a single gland, the rectal temperature, milk appearance, and California Mastitis Test score were assessed. Cows were randomly assigned within each site to be treated either with meloxicam or a placebo (control). All cows were additionally treated with 1 to 4 intramammary infusions of cephalexin and kanamycin at 24-h intervals. Prior to treatment and at 14 and 21 d posttreatment, milk samples were collected for bacteriology and somatic cell count. Cows were bred by artificial insemination and pregnancy status was subsequently defined. General estimating equations were used to determine the effect of treatment (meloxicam versus control) on bacteriological cure, somatic cell count, the probability of being inseminated by 21 d after the voluntary waiting period, the probability of conception to first artificial insemination, the number of artificial insemination/conception, the probability of pregnancy by 120 or 200 d postcalving, and the risk of removal by 300 d after treatment. Cox's proportional hazards models were used to test the effect of treatment on the calving to first insemination and calving to conception intervals. Groups did not differ in terms of age, clot score, California Mastitis Test score, rectal temperature, number of antimicrobial treatments given or bacteria present at the time of enrollment, but cows treated with meloxicam had greater days in milk at enrollment. Cows treated with meloxicam had a higher bacteriological cure proportion than those treated with the placebo [0.66 (standard error = 0.04) versus 0.50 (standard error = 0.06), respectively], although the proportion of glands from which no bacteria were isolated posttreatment did not differ between groups. No difference was observed in the somatic cell count between groups pre- or posttreatment. The proportion of cows that underwent artificial insemination by 21 d after the voluntary waiting period was unaffected by treatment. Treatment with meloxicam was associated with a higher proportion of cows conceiving to their first artificial insemination (0.31 versus 0.21), and a higher proportion of meloxicam-treated cows were pregnant by 120 d after calving (0.40 versus 0.31). The number of artificial inseminations required to achieve conception was lower in the meloxicam compared with control cows (2.43 versus 2.92). No difference was observed between groups in the proportion of cows pregnant by 200 d after calving or in the proportion of cows that were culled, died, or sold by 300 d after calving (17\% versus 21\% for meloxicam versus control, respectively). It was concluded that use of meloxicam, in conjunction with antimicrobial therapy, for mild to moderate cases of clinical mastitis, resulted in a higher probability of bacteriological cure, an increased probability of conception to first artificial insemination, fewer artificial inseminations, and a greater proportion of cows pregnant by 120 d in milk.},
  author       = {McDougall, S and Abbeloos, E and Piepers, Sofie and Rao, AS and Astiz, S and van Werven, T and Statham, J and Perez-Villalobos, N},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {HOLSTEIN DAIRY-COWS,SURVIVAL ANALYSIS,cure,fertility,mastitis,nonsteroidal anti-inflammatory drug,FLUNIXIN MEGLUMINE,EARLY LACTATION,FOLLICULAR FUNCTION,BODY-CONDITION SCORE,FINNISH AYRSHIRE COWS,FLIGHT MASS-SPECTROMETRY,NEW-YORK-STATE,ESCHERICHIA-COLI MASTITIS},
  language     = {eng},
  number       = {3},
  pages        = {2026--2042},
  title        = {Addition of meloxicam to the treatment of clinical mastitis improves subsequent reproductive performance},
  url          = {http://dx.doi.org/10.3168/jds.2015-9615},
  volume       = {99},
  year         = {2016},
}

Chicago
McDougall, S, E Abbeloos, Sofie Piepers, AS Rao, S Astiz, T van Werven, J Statham, and N Perez-Villalobos. 2016. “Addition of Meloxicam to the Treatment of Clinical Mastitis Improves Subsequent Reproductive Performance.” Journal of Dairy Science 99 (3): 2026–2042.
APA
McDougall, S., Abbeloos, E., Piepers, S., Rao, A., Astiz, S., van Werven, T., Statham, J., et al. (2016). Addition of meloxicam to the treatment of clinical mastitis improves subsequent reproductive performance. JOURNAL OF DAIRY SCIENCE, 99(3), 2026–2042.
Vancouver
1.
McDougall S, Abbeloos E, Piepers S, Rao A, Astiz S, van Werven T, et al. Addition of meloxicam to the treatment of clinical mastitis improves subsequent reproductive performance. JOURNAL OF DAIRY SCIENCE. 2016;99(3):2026–42.
MLA
McDougall, S, E Abbeloos, Sofie Piepers, et al. “Addition of Meloxicam to the Treatment of Clinical Mastitis Improves Subsequent Reproductive Performance.” JOURNAL OF DAIRY SCIENCE 99.3 (2016): 2026–2042. Print.