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Quantification of antimicrobial consumption in adult cattle on dairy herds in Flanders, Belgium, and associations with udder health, milk quality, and production performance

Marina Stevens UGent, Sofie Piepers UGent, Karlien Supré, Jeroen Dewulf UGent and Sarne De Vliegher UGent (2016) JOURNAL OF DAIRY SCIENCE. 99(3). p.2118-2130
abstract
The main objective of this study was to quantify the (compound-specific) antimicrobial consumption (AMC) in adult cattle in a convenience sample of Flemish dairy herds. Antimicrobial consumption data were obtained between 2012 and 2013 by "garbage can audits" and expressed as antimicrobial treatment incidence (ATI), with the unit of the ATI being the number of defined daily doses animal (DDDA) used per 1,000 cow-days. Herds were stratified by DDDA into low-, medium-, and high-consuming herds to study the AMC per route of administration, and associations with parameters reflecting udder health, milk quality, and production performances were examined. The average ATI in adult dairy cattle for all compounds was 20.78 DDDA (per 1,000 cow-days). Large variation existed between herds (ranging from 8.68 to 41.62 DDDA). Fourth-generation cephalosporins were used most (4.99 DDDA), followed by penicillins (3.70 DDDA) and third-generation cephalosporins (2.95 DDDA). The average ATI of the critically important antimicrobials for human health (i.e., third- and fourth-generation cephalosporins and fluoroquinolones according to the World Organisation for Animal Health classification) was somewhat lower than the average ATI of the other antimicrobials (8.59 and 12.18 DDDA, respectively). The average ATI for intramammary treatment of (sub)clinical mastitis, for dry-cow therapy, and for systemically administered antimicrobials was 6.30, 6.89, and 7.44 DDDA, respectively. In low-consuming herds, most antimicrobials were being used for dry-cow therapy, whereas in high consuming herds, most antimicrobials were being used as injectable or intramammary mastitis therapy. The incidence rate of treated mastitis was positively associated with ATI. Herds that applied blanket dry-cow therapy tended to have a higher ATI than herds in which cows were selectively dried off with long-acting antimicrobials. The ATI decreased with an increasing prevalence of primiparous cows.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DRUG-USE, udder health, VETERINARY-MEDICINE, CLINICAL MASTITIS, FOOD ANIMALS, USAGE, FARMS, RESISTANCE, ANTIBIOTICS, ONTARIO, AGENTS, production, milk quality, dairy herd, antimicrobial consumption
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
99
issue
3
pages
2118 - 2130
Web of Science type
Article
Web of Science id
000370100600045
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
2.474 (2016)
JCR rank
3/58 (2016)
JCR quartile
1 (2016)
ISSN
0022-0302
DOI
10.3168/jds.2015-10199
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7170541
handle
http://hdl.handle.net/1854/LU-7170541
date created
2016-03-31 12:58:47
date last changed
2016-12-19 15:42:21
@article{7170541,
  abstract     = {The main objective of this study was to quantify the (compound-specific) antimicrobial consumption (AMC) in adult cattle in a convenience sample of Flemish dairy herds. Antimicrobial consumption data were obtained between 2012 and 2013 by {\textacutedbl}garbage can audits{\textacutedbl} and expressed as antimicrobial treatment incidence (ATI), with the unit of the ATI being the number of defined daily doses animal (DDDA) used per 1,000 cow-days. Herds were stratified by DDDA into low-, medium-, and high-consuming herds to study the AMC per route of administration, and associations with parameters reflecting udder health, milk quality, and production performances were examined. The average ATI in adult dairy cattle for all compounds was 20.78 DDDA (per 1,000 cow-days). Large variation existed between herds (ranging from 8.68 to 41.62 DDDA). Fourth-generation cephalosporins were used most (4.99 DDDA), followed by penicillins (3.70 DDDA) and third-generation cephalosporins (2.95 DDDA). The average ATI of the critically important antimicrobials for human health (i.e., third- and fourth-generation cephalosporins and fluoroquinolones according to the World Organisation for Animal Health classification) was somewhat lower than the average ATI of the other antimicrobials (8.59 and 12.18 DDDA, respectively). The average ATI for intramammary treatment of (sub)clinical mastitis, for dry-cow therapy, and for systemically administered antimicrobials was 6.30, 6.89, and 7.44 DDDA, respectively. In low-consuming herds, most antimicrobials were being used for dry-cow therapy, whereas in high consuming herds, most antimicrobials were being used as injectable or intramammary mastitis therapy. The incidence rate of treated mastitis was positively associated with ATI. Herds that applied blanket dry-cow therapy tended to have a higher ATI than herds in which cows were selectively dried off with long-acting antimicrobials. The ATI decreased with an increasing prevalence of primiparous cows.},
  author       = {Stevens, Marina and Piepers, Sofie and Supr{\'e}, Karlien and Dewulf, Jeroen and De Vliegher, Sarne},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {DRUG-USE,udder health,VETERINARY-MEDICINE,CLINICAL MASTITIS,FOOD ANIMALS,USAGE,FARMS,RESISTANCE,ANTIBIOTICS,ONTARIO,AGENTS,production,milk quality,dairy herd,antimicrobial consumption},
  language     = {eng},
  number       = {3},
  pages        = {2118--2130},
  title        = {Quantification of antimicrobial consumption in adult cattle on dairy herds in Flanders, Belgium, and associations with udder health, milk quality, and production performance},
  url          = {http://dx.doi.org/10.3168/jds.2015-10199},
  volume       = {99},
  year         = {2016},
}

Chicago
Stevens, Marina, Sofie Piepers, Karlien Supré, Jeroen Dewulf, and Sarne De Vliegher. 2016. “Quantification of Antimicrobial Consumption in Adult Cattle on Dairy Herds in Flanders, Belgium, and Associations with Udder Health, Milk Quality, and Production Performance.” Journal of Dairy Science 99 (3): 2118–2130.
APA
Stevens, Marina, Piepers, S., Supré, K., Dewulf, J., & De Vliegher, S. (2016). Quantification of antimicrobial consumption in adult cattle on dairy herds in Flanders, Belgium, and associations with udder health, milk quality, and production performance. JOURNAL OF DAIRY SCIENCE, 99(3), 2118–2130.
Vancouver
1.
Stevens M, Piepers S, Supré K, Dewulf J, De Vliegher S. Quantification of antimicrobial consumption in adult cattle on dairy herds in Flanders, Belgium, and associations with udder health, milk quality, and production performance. JOURNAL OF DAIRY SCIENCE. 2016;99(3):2118–30.
MLA
Stevens, Marina, Sofie Piepers, Karlien Supré, et al. “Quantification of Antimicrobial Consumption in Adult Cattle on Dairy Herds in Flanders, Belgium, and Associations with Udder Health, Milk Quality, and Production Performance.” JOURNAL OF DAIRY SCIENCE 99.3 (2016): 2118–2130. Print.