Advanced search
1 file | 455.75 KB

Comparison of anthropometric measurements of adiposity in relation to cancer risk: a systematic review of prospective studies

(2016) CANCER CAUSES & CONTROL. 27(3). p.291-300
Author
Organization
Abstract
Purpose: In epidemiology, the relationship between increased adiposity and cancer risk has long been recognized. However, whether the association is the same for measures of abdominal or whole body adiposity is unclear. The aim of this systematic review is to compare cancer risk, associated with body mass index (BMI), an indicator of whole body adiposity, with indicators of abdominal adiposity in studies in which these indicators have been directly measured. Methods: We conducted a systematic search from 1974 (EMBASE) and 1988 (PubMed) to September 2015 with keywords related to adiposity and cancer. Included studies were limited to cohort studies reporting directly measured anthropometry and performing mutually adjusted analyses. Results: Thirteen articles were identified, with two reporting on breast cancer, three on colorectal cancer, three on endometrial cancer, two on gastro-oesophageal cancer, two on renal cancer, one on ovarian cancer, one on bladder cancer, one on liver and biliary tract cancer and one on leukaemia. Evidence suggests that abdominal adiposity is a stronger predictor than whole body adiposity for gastro-oesophageal, leukaemia and liver and biliary tract cancer in men and women and for renal cancer in women. Abdominal adiposity was a stronger predictor for bladder and colorectal cancer in women, while only BMI was a predictor in men. In contrast, BMI appears to be a stronger predictor for ovarian cancer. For breast and endometrial cancer, both measures were predictors for cancer risk in postmenopausal women. Conclusions: Only few studies used mutually adjusted and measured anthropometric indicators when studying adiposity-cancer associations. Further research investigating cancer risk and adiposity should include more accurate non-invasive indicators of body fat deposition and focus on the understudied cancer types, namely leukaemia, ovarian, bladder and liver and biliary tract cancer.
Keywords
BREAST-CANCER, INSULIN-RESISTANCE, POSTMENOPAUSAL WOMEN, BODY-MASS INDEX, Cancer, Neoplasm, Adiposity, Anthropometry, PROSPECTIVE COHORT, ABDOMINAL OBESITY, OVARIAN-CANCER, RECTAL-CANCER, EPIC COHORT, SIZE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 455.75 KB

Citation

Please use this url to cite or link to this publication:

Chicago
De Ridder, Josefine, Cristina Julián-Almárcegui, Amy Mullee, Sabina Rinaldi, Koen Van Herck, German Vicente-Rodríguez, and Inge Huybrechts. 2016. “Comparison of Anthropometric Measurements of Adiposity in Relation to Cancer Risk: a Systematic Review of Prospective Studies.” Cancer Causes & Control 27 (3): 291–300.
APA
De Ridder, Josefine, Julián-Almárcegui, C., Mullee, A., Rinaldi, S., Van Herck, K., Vicente-Rodríguez, G., & Huybrechts, I. (2016). Comparison of anthropometric measurements of adiposity in relation to cancer risk: a systematic review of prospective studies. CANCER CAUSES & CONTROL, 27(3), 291–300.
Vancouver
1.
De Ridder J, Julián-Almárcegui C, Mullee A, Rinaldi S, Van Herck K, Vicente-Rodríguez G, et al. Comparison of anthropometric measurements of adiposity in relation to cancer risk: a systematic review of prospective studies. CANCER CAUSES & CONTROL. 2016;27(3):291–300.
MLA
De Ridder, Josefine, Cristina Julián-Almárcegui, Amy Mullee, et al. “Comparison of Anthropometric Measurements of Adiposity in Relation to Cancer Risk: a Systematic Review of Prospective Studies.” CANCER CAUSES & CONTROL 27.3 (2016): 291–300. Print.
@article{7167496,
  abstract     = {Purpose: In epidemiology, the relationship between increased adiposity and cancer risk has long been recognized. However, whether the association is the same for measures of abdominal or whole body adiposity is unclear. The aim of this systematic review is to compare cancer risk, associated with body mass index (BMI), an indicator of whole body adiposity, with indicators of abdominal adiposity in studies in which these indicators have been directly measured. 
Methods: We conducted a systematic search from 1974 (EMBASE) and 1988 (PubMed) to September 2015 with keywords related to adiposity and cancer. Included studies were limited to cohort studies reporting directly measured anthropometry and performing mutually adjusted analyses. 
Results: Thirteen articles were identified, with two reporting on breast cancer, three on colorectal cancer, three on endometrial cancer, two on gastro-oesophageal cancer, two on renal cancer, one on ovarian cancer, one on bladder cancer, one on liver and biliary tract cancer and one on leukaemia. Evidence suggests that abdominal adiposity is a stronger predictor than whole body adiposity for gastro-oesophageal, leukaemia and liver and biliary tract cancer in men and women and for renal cancer in women. Abdominal adiposity was a stronger predictor for bladder and colorectal cancer in women, while only BMI was a predictor in men. In contrast, BMI appears to be a stronger predictor for ovarian cancer. For breast and endometrial cancer, both measures were predictors for cancer risk in postmenopausal women. 
Conclusions: Only few studies used mutually adjusted and measured anthropometric indicators when studying adiposity-cancer associations. Further research investigating cancer risk and adiposity should include more accurate non-invasive indicators of body fat deposition and focus on the understudied cancer types, namely leukaemia, ovarian, bladder and liver and biliary tract cancer.},
  author       = {De Ridder, Josefine and Juli{\'a}n-Alm{\'a}rcegui, Cristina and Mullee, Amy and Rinaldi, Sabina and Van Herck, Koen and Vicente-Rodr{\'i}guez, German and Huybrechts, Inge},
  issn         = {0957-5243},
  journal      = {CANCER CAUSES \& CONTROL},
  language     = {eng},
  number       = {3},
  pages        = {291--300},
  title        = {Comparison of anthropometric measurements of adiposity in relation to cancer risk: a systematic review of prospective studies},
  url          = {http://dx.doi.org/10.1007/s10552-015-0709-y},
  volume       = {27},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: