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A single-center comparison of 22 competing definitions of delayed graft function after kidney transplantation

(2016) ANNALS OF TRANSPLANTATION. 21. p.152-159
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Abstract
Background: This study compared 22 different definitions of delayed graft function (DGF) following kidney transplantation. Materials/Methods: Our study included 497 kidney transplantations from deceased donors at our center between 2005 and 2011. Graft survival analysis including log-rank tests and Cox proportional hazards model was performed. Sensitivity and specificity were calculated in relation to graft failure. Results: Mean follow-up time was 5.1 years. All dialysis-based definitions were associated with graft failure and characterized by high specificity (88–97%), but low sensitivity (25–29%). Hazard ratios ranged from 2.87 to 13.73, with increased risk when dialysis was required earlier and more frequently. The urine output-based definition performed similarly, with an association with graft failure and high specificity (96%), but low sensitivity (21%). Serum creatinine-based definitions were more heterogeneous. Higher sensitivity (4–67%) was found in some of these definitions, but was often associated with lower specificity (47–96%), losing the association with graft failure. Definitions combining different criteria varied in sensitivity (17–62%) and specificity (60–96%). However, some were able to achieve higher sensitivity without compromising too much on specificity, while keeping the association with graft failure. Conclusions: Our results indicate a potential advantage of combined definitions, because they are able to detect a larger group of recipients with increased risk of graft failure.
Keywords
Graft Survival, Kidney Transplantation, Delayed Graft Function, SURVIVAL, RISK, IMPACT, OUTCOMES, ALLOGRAFT, RENAL-TRANSPLANTATION

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Please use this url to cite or link to this publication:

Chicago
Decruyenaere, Philippe, Alexander Decruyenaere, PATRICK PEETERS, and Frank Vermassen. 2016. “A Single-center Comparison of 22 Competing Definitions of Delayed Graft Function After Kidney Transplantation.” Annals of Transplantation 21: 152–159.
APA
Decruyenaere, P., Decruyenaere, A., PEETERS, P., & Vermassen, F. (2016). A single-center comparison of 22 competing definitions of delayed graft function after kidney transplantation. ANNALS OF TRANSPLANTATION, 21, 152–159.
Vancouver
1.
Decruyenaere P, Decruyenaere A, PEETERS P, Vermassen F. A single-center comparison of 22 competing definitions of delayed graft function after kidney transplantation. ANNALS OF TRANSPLANTATION. 2016;21:152–9.
MLA
Decruyenaere, Philippe, Alexander Decruyenaere, PATRICK PEETERS, et al. “A Single-center Comparison of 22 Competing Definitions of Delayed Graft Function After Kidney Transplantation.” ANNALS OF TRANSPLANTATION 21 (2016): 152–159. Print.
@article{7151410,
  abstract     = {Background: This study compared 22 different definitions of delayed graft function (DGF) following kidney transplantation.
Materials/Methods: Our study included 497 kidney transplantations from deceased donors at our center between 2005 and 2011. Graft survival analysis including log-rank tests and Cox proportional hazards model was performed. Sensitivity and specificity were calculated in relation to graft failure.
Results: Mean follow-up time was 5.1 years. All dialysis-based definitions were associated with graft failure and characterized by high specificity (88--97\%), but low sensitivity (25--29\%). Hazard ratios ranged from 2.87 to 13.73, with increased risk when dialysis was required earlier and more frequently. The urine output-based definition performed similarly, with an association with graft failure and high specificity (96\%), but low sensitivity (21\%). Serum creatinine-based definitions were more heterogeneous. Higher sensitivity (4--67\%) was found in some of these definitions, but was often associated with lower specificity (47--96\%), losing the association with graft failure. Definitions combining different criteria varied in sensitivity (17--62\%) and specificity (60--96\%). However, some were able to achieve higher sensitivity without compromising too much on specificity, while keeping the association with graft failure.
Conclusions: Our results indicate a potential advantage of combined definitions, because they are able to detect a larger group of recipients with increased risk of graft failure.},
  author       = {Decruyenaere, Philippe and Decruyenaere, Alexander and Peeters, Patrick and Vermassen, Frank},
  issn         = {1425-9524},
  journal      = {ANNALS OF TRANSPLANTATION},
  keyword      = {Graft Survival,Kidney Transplantation,Delayed Graft Function,SURVIVAL,RISK,IMPACT,OUTCOMES,ALLOGRAFT,RENAL-TRANSPLANTATION},
  language     = {eng},
  pages        = {152--159},
  title        = {A single-center comparison of 22 competing definitions of delayed graft function after kidney transplantation},
  url          = {http://dx.doi.org/10.12659/AOT.896117},
  volume       = {21},
  year         = {2016},
}

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