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Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection

(2016) RSC ADVANCES. 6(24). p.20447-20452
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Abstract
Multifunctional silver alginate hydrogel microspheres are assembled via a template assisted approach using calcium carbonate cores. Sodium alginate is immobilized into the highly porous structure of calcium carbonate microspheres followed by cross-linking in the presence of silver ions. The simultaneous processes of the growth of silver nanoparticles in the alginate matrix and the removal of the calcium carbonate template are triggered by ascorbic acid. The abundance of silver nanoparticles and their interparticular junctions in the alginate network allow for the detection of solutes using Raman spectroscopy using the surface of the plasmonic microspheres. Rhodamine B was used to illustrate the potential applications of such multifunctional plasmonic alginate hydrogel microspheres for sensing at low concentrations. A proof of principle for using such particles for the quick identification of microorganisms is then demonstrated using the Escherichia coli bacterium.
Keywords
POLYELECTROLYTE MICROCAPSULES, CALCIUM-CARBONATE PARTICLES, MULTILAYER MICROCAPSULES, SERS PLATFORM, IN-VITRO, NANOPARTICLES, BEADS, GOLD, ENCAPSULATION, SUBSTRATE

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MLA
Lengert, Ekaterina, et al. “Hollow Silver Alginate Microspheres for Drug Delivery and Surface Enhanced Raman Scattering Detection.” RSC ADVANCES, vol. 6, no. 24, 2016, pp. 20447–52, doi:10.1039/C6RA02019D.
APA
Lengert, E., Yashchenok, A. M., Atkin, V., Lapanje, A., Gorin, D. A., Sukhorukov, G. B., & Parakhonskiy, B. (2016). Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection. RSC ADVANCES, 6(24), 20447–20452. https://doi.org/10.1039/C6RA02019D
Chicago author-date
Lengert, Ekaterina, Alexey M. Yashchenok, Vsevolod Atkin, Ales Lapanje, Dmitry A. Gorin, Gleb B. Sukhorukov, and Bogdan Parakhonskiy. 2016. “Hollow Silver Alginate Microspheres for Drug Delivery and Surface Enhanced Raman Scattering Detection.” RSC ADVANCES 6 (24): 20447–52. https://doi.org/10.1039/C6RA02019D.
Chicago author-date (all authors)
Lengert, Ekaterina, Alexey M. Yashchenok, Vsevolod Atkin, Ales Lapanje, Dmitry A. Gorin, Gleb B. Sukhorukov, and Bogdan Parakhonskiy. 2016. “Hollow Silver Alginate Microspheres for Drug Delivery and Surface Enhanced Raman Scattering Detection.” RSC ADVANCES 6 (24): 20447–20452. doi:10.1039/C6RA02019D.
Vancouver
1.
Lengert E, Yashchenok AM, Atkin V, Lapanje A, Gorin DA, Sukhorukov GB, et al. Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection. RSC ADVANCES. 2016;6(24):20447–52.
IEEE
[1]
E. Lengert et al., “Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection,” RSC ADVANCES, vol. 6, no. 24, pp. 20447–20452, 2016.
@article{7150026,
  abstract     = {{Multifunctional silver alginate hydrogel microspheres are assembled via a template assisted approach using calcium carbonate cores. Sodium alginate is immobilized into the highly porous structure of calcium carbonate microspheres followed by cross-linking in the presence of silver ions. The simultaneous processes of the growth of silver nanoparticles in the alginate matrix and the removal of the calcium carbonate template are triggered by ascorbic acid. The abundance of silver nanoparticles and their interparticular junctions in the alginate network allow for the detection of solutes using Raman spectroscopy using the surface of the plasmonic microspheres. Rhodamine B was used to illustrate the potential applications of such multifunctional plasmonic alginate hydrogel microspheres for sensing at low concentrations. A proof of principle for using such particles for the quick identification of microorganisms is then demonstrated using the Escherichia coli bacterium.}},
  author       = {{Lengert, Ekaterina and Yashchenok, Alexey M. and Atkin, Vsevolod and Lapanje, Ales and Gorin, Dmitry A. and Sukhorukov, Gleb B. and Parakhonskiy, Bogdan}},
  issn         = {{2046-2069}},
  journal      = {{RSC ADVANCES}},
  keywords     = {{POLYELECTROLYTE MICROCAPSULES,CALCIUM-CARBONATE PARTICLES,MULTILAYER MICROCAPSULES,SERS PLATFORM,IN-VITRO,NANOPARTICLES,BEADS,GOLD,ENCAPSULATION,SUBSTRATE}},
  language     = {{eng}},
  number       = {{24}},
  pages        = {{20447--20452}},
  title        = {{Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection}},
  url          = {{http://doi.org/10.1039/C6RA02019D}},
  volume       = {{6}},
  year         = {{2016}},
}

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