Advanced search

Composite magnetite and protein containing CaCO3 crystals : external manipulation and vaterite → calcite recrystallization-mediated release performance

(2015) ACS APPLIED MATERIALS & INTERFACES. 7(38). p.21315-21325
Author
Organization
Abstract
Biocompatibility and high loading capacity of mesoporous CaCO3 vaterite crystals give an option to utilize the polycrystals for a wide range of (bio)applications. Formation and transformations of calcium carbonate polymorphs have been studied for decades, aimed at both basic and applied research interests. Here, composite multilayer-coated calcium carbonate polycrystals containing Fe3O4 magnetite nanoparticles and model protein lysozyme are fabricated. The structure of the composite polycrystals and vaterite -> calcite recrystallization kinetics are studied. The recrystallization results in release of both loaded protein and Fe3O4 nanoparticles (magnetic manipulation is thus lost). Fe3O4 nanoparticles enhance the recrystallization that can be induced by reduction of the local pH with citric acid and reduction of the polycrystal crystallinity. Oppositely, the layer-by-layer assembled poly(allylamine hydrochloride)/poly(sodium styrenesulfonate) polyelectrolyte coating significantly inhibits the vaterite -> calcite recrystallization (from hours to days) most likely due to suppression of the ion exchange giving an option to easily tune the release kinetics for a wide time scale, for example, for prolonged release. Moreover, the recrystallization of the coated crystals results in formulation of multilayer capsules keeping the feature of external manipulation. This study can help to design multifunctional microstructures with tailor-made characteristics for loading and controlled release as well as for external manipulation.
Keywords
calcium carbonate crystals, magnetite nanoparticles, coprecipitation, vaterite -> calcite recrystallization, layer-by-layer assembly, CARBONATE PARTICLES, POLYELECTROLYTE MICROCAPSULES, PHASE-TRANSITION, NANOPARTICLES, ENCAPSULATION, TEMPLATES, MICROPARTICLES, NANOTUBES, MECHANISM, DELIVERY

Citation

Please use this url to cite or link to this publication:

Chicago
Sergeeva, A, R Sergeev, E Lengert, A Zakharevich, Bogdan Parakhonskiy, D Gorin, S Sergeev, and D Volodkin. 2015. “Composite Magnetite and Protein Containing CaCO3 Crystals : External Manipulation and Vaterite → Calcite Recrystallization-mediated Release Performance.” Acs Applied Materials & Interfaces 7 (38): 21315–21325.
APA
Sergeeva, A., Sergeev, R., Lengert, E., Zakharevich, A., Parakhonskiy, B., Gorin, D., Sergeev, S., et al. (2015). Composite magnetite and protein containing CaCO3 crystals : external manipulation and vaterite → calcite recrystallization-mediated release performance. ACS APPLIED MATERIALS & INTERFACES, 7(38), 21315–21325.
Vancouver
1.
Sergeeva A, Sergeev R, Lengert E, Zakharevich A, Parakhonskiy B, Gorin D, et al. Composite magnetite and protein containing CaCO3 crystals : external manipulation and vaterite → calcite recrystallization-mediated release performance. ACS APPLIED MATERIALS & INTERFACES. 2015;7(38):21315–25.
MLA
Sergeeva, A, R Sergeev, E Lengert, et al. “Composite Magnetite and Protein Containing CaCO3 Crystals : External Manipulation and Vaterite → Calcite Recrystallization-mediated Release Performance.” ACS APPLIED MATERIALS & INTERFACES 7.38 (2015): 21315–21325. Print.
@article{7149893,
  abstract     = {Biocompatibility and high loading capacity of mesoporous CaCO3 vaterite crystals give an option to utilize the polycrystals for a wide range of (bio)applications. Formation and transformations of calcium carbonate polymorphs have been studied for decades, aimed at both basic and applied research interests. Here, composite multilayer-coated calcium carbonate polycrystals containing Fe3O4 magnetite nanoparticles and model protein lysozyme are fabricated. The structure of the composite polycrystals and vaterite -{\textrangle} calcite recrystallization kinetics are studied. The recrystallization results in release of both loaded protein and Fe3O4 nanoparticles (magnetic manipulation is thus lost). Fe3O4 nanoparticles enhance the recrystallization that can be induced by reduction of the local pH with citric acid and reduction of the polycrystal crystallinity. Oppositely, the layer-by-layer assembled poly(allylamine hydrochloride)/poly(sodium styrenesulfonate) polyelectrolyte coating significantly inhibits the vaterite -{\textrangle} calcite recrystallization (from hours to days) most likely due to suppression of the ion exchange giving an option to easily tune the release kinetics for a wide time scale, for example, for prolonged release. Moreover, the recrystallization of the coated crystals results in formulation of multilayer capsules keeping the feature of external manipulation. This study can help to design multifunctional microstructures with tailor-made characteristics for loading and controlled release as well as for external manipulation.},
  author       = {Sergeeva, A and Sergeev, R and Lengert, E and Zakharevich, A and Parakhonskiy, Bogdan and Gorin, D and Sergeev, S and Volodkin, D},
  issn         = {1944-8244},
  journal      = {ACS APPLIED MATERIALS \& INTERFACES},
  keyword      = {calcium carbonate crystals,magnetite nanoparticles,coprecipitation,vaterite -{\textrangle} calcite recrystallization,layer-by-layer assembly,CARBONATE PARTICLES,POLYELECTROLYTE MICROCAPSULES,PHASE-TRANSITION,NANOPARTICLES,ENCAPSULATION,TEMPLATES,MICROPARTICLES,NANOTUBES,MECHANISM,DELIVERY},
  language     = {eng},
  number       = {38},
  pages        = {21315--21325},
  title        = {Composite magnetite and protein containing CaCO3 crystals : external manipulation and vaterite {\textrightarrow} calcite recrystallization-mediated release performance},
  url          = {http://dx.doi.org/10.1021/acsami.5b05848},
  volume       = {7},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: