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Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus: studies in the pig model of influenza

Yu Qiu, Karl De hert UGent and Kristien Van Reeth UGent (2015) VETERINARY RESEARCH. 46.
abstract
Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 pandemic H1N1 (pH1N1) virus and three different European H1 swine influenza virus (SIV) lineages, and b) these H1 viruses and a European H3N2 SIV. Pigs were inoculated intranasally with representative strains of each virus lineage with 6- and 17-week intervals between H1 inoculations and between H1 and H3 inoculations, respectively. Virus titers in nasal swabs and/or tissues of the respiratory tract were determined after each inoculation. There was substantial though differing cross-protection between pH1N1 and other H1 viruses, which was directly correlated with the relatedness in the viral hemagglutinin (HA) and neuraminidase (NA) proteins. Cross-protection against H3N2 was almost complete in pigs with immunity against H1N2, but was weak in H1N1/pH1N1-immune pigs. In conclusion, infection with a live, wild type influenza virus may offer substantial cross-lineage protection against viruses of the same HA and/or NA subtype. True heterosubtypic protection, in contrast, appears to be minimal in natural influenza virus hosts. We discuss our findings in the light of the zoonotic and pandemic risks of SIVs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
A VIRUS, GENETIC REASSORTMENT, H3N2 VIRUS, NEURAMINIDASE, MICE, HUMANS, TRANSMISSION, ANTIBODIES, ORIGIN, RESPONSES
journal title
VETERINARY RESEARCH
Vet. Res.
volume
46
article number
105
pages
10 pages
Web of Science type
Article
Web of Science id
000361785200003
JCR category
VETERINARY SCIENCES
JCR impact factor
2.928 (2015)
JCR rank
3/138 (2015)
JCR quartile
1 (2015)
ISSN
0928-4249
DOI
10.1186/s13567-015-0236-6
project
RT 09/6227
project
FP7-GA 258084
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
7147264
handle
http://hdl.handle.net/1854/LU-7147264
date created
2016-03-15 10:25:59
date last changed
2016-12-21 15:42:49
@article{7147264,
  abstract     = {Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 pandemic H1N1 (pH1N1) virus and three different European H1 swine influenza virus (SIV) lineages, and b) these H1 viruses and a European H3N2 SIV. Pigs were inoculated intranasally with representative strains of each virus lineage with 6- and 17-week intervals between H1 inoculations and between H1 and H3 inoculations, respectively. Virus titers in nasal swabs and/or tissues of the respiratory tract were determined after each inoculation. There was substantial though differing cross-protection between pH1N1 and other H1 viruses, which was directly correlated with the relatedness in the viral hemagglutinin (HA) and neuraminidase (NA) proteins. Cross-protection against H3N2 was almost complete in pigs with immunity against H1N2, but was weak in H1N1/pH1N1-immune pigs. In conclusion, infection with a live, wild type influenza virus may offer substantial cross-lineage protection against viruses of the same HA and/or NA subtype. True heterosubtypic protection, in contrast, appears to be minimal in natural influenza virus hosts. We discuss our findings in the light of the zoonotic and pandemic risks of SIVs.},
  articleno    = {105},
  author       = {Qiu, Yu and De hert, Karl and Van Reeth, Kristien},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keyword      = {A VIRUS,GENETIC REASSORTMENT,H3N2 VIRUS,NEURAMINIDASE,MICE,HUMANS,TRANSMISSION,ANTIBODIES,ORIGIN,RESPONSES},
  language     = {eng},
  pages        = {10},
  title        = {Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus: studies in the pig model of influenza},
  url          = {http://dx.doi.org/10.1186/s13567-015-0236-6},
  volume       = {46},
  year         = {2015},
}

Chicago
Qiu, Yu, De hertKarl, and Kristien Van Reeth. 2015. “Cross-protection Against European Swine Influenza Viruses in the Context of Infection Immunity Against the 2009 Pandemic H1N1 Virus: Studies in the Pig Model of Influenza.” Veterinary Research 46.
APA
Qiu, Y., De hertKarl, & Van Reeth, K. (2015). Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus: studies in the pig model of influenza. VETERINARY RESEARCH, 46.
Vancouver
1.
Qiu Y, De hertKarl, Van Reeth K. Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus: studies in the pig model of influenza. VETERINARY RESEARCH. 2015;46.
MLA
Qiu, Yu, De hertKarl, and Kristien Van Reeth. “Cross-protection Against European Swine Influenza Viruses in the Context of Infection Immunity Against the 2009 Pandemic H1N1 Virus: Studies in the Pig Model of Influenza.” VETERINARY RESEARCH 46 (2015): n. pag. Print.