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Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1 alpha,25-dihydroxyvitamin D3

(2009) TETRAHEDRON LETTERS. 50(28). p.4174-4177
Author
Organization
Abstract
In search of analogs of 1α,25-dihydroxyvitamin D3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro[4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way.
Keywords
Spirocyclic decanones, Calcitriol analogs, Enantioselective synthesis

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Citation

Please use this url to cite or link to this publication:

MLA
De Buysser, Frederik et al. “Synthesis of 22-oxaspiro[4.5]decane CD-ring Modified Analogs of 1 Alpha,25-dihydroxyvitamin D3.” Ed. Samir Zard. TETRAHEDRON LETTERS 50.28 (2009): 4174–4177. Print.
APA
De Buysser, F., Verlinden, L., Verstuyf, A., & De Clercq, P. (2009). Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1 alpha,25-dihydroxyvitamin D3. (S. Zard, Ed.)TETRAHEDRON LETTERS, 50(28), 4174–4177.
Chicago author-date
De Buysser, Frederik, Lieve Verlinden, Annemieke Verstuyf, and Pierre De Clercq. 2009. “Synthesis of 22-oxaspiro[4.5]decane CD-ring Modified Analogs of 1 Alpha,25-dihydroxyvitamin D3.” Ed. Samir Zard. Tetrahedron Letters 50 (28): 4174–4177.
Chicago author-date (all authors)
De Buysser, Frederik, Lieve Verlinden, Annemieke Verstuyf, and Pierre De Clercq. 2009. “Synthesis of 22-oxaspiro[4.5]decane CD-ring Modified Analogs of 1 Alpha,25-dihydroxyvitamin D3.” Ed. Samir Zard. Tetrahedron Letters 50 (28): 4174–4177.
Vancouver
1.
De Buysser F, Verlinden L, Verstuyf A, De Clercq P. Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1 alpha,25-dihydroxyvitamin D3. Zard S, editor. TETRAHEDRON LETTERS. Elsevier; 2009;50(28):4174–7.
IEEE
[1]
F. De Buysser, L. Verlinden, A. Verstuyf, and P. De Clercq, “Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1 alpha,25-dihydroxyvitamin D3,” TETRAHEDRON LETTERS, vol. 50, no. 28, pp. 4174–4177, 2009.
@article{714708,
  abstract     = {{In search of analogs of 1α,25-dihydroxyvitamin D3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro[4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way.}},
  author       = {{De Buysser, Frederik and Verlinden, Lieve and Verstuyf, Annemieke and De Clercq, Pierre}},
  editor       = {{Zard, Samir}},
  issn         = {{0040-4039}},
  journal      = {{TETRAHEDRON LETTERS}},
  keywords     = {{Spirocyclic decanones,Calcitriol analogs,Enantioselective synthesis}},
  language     = {{eng}},
  number       = {{28}},
  pages        = {{4174--4177}},
  publisher    = {{Elsevier}},
  title        = {{Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1 alpha,25-dihydroxyvitamin D3}},
  url          = {{http://dx.doi.org/10.1016/j.tetlet.2009.05.005}},
  volume       = {{50}},
  year         = {{2009}},
}

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