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The mycotoxin definition reconsidered towards fungal cyclic depsipeptides

Lien Taevernier (UGent) , Evelien Wynendaele (UGent) , Leen De Vreese (UGent) , Christian Burvenich (UGent) and Bart De Spiegeleer (UGent)
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Abstract
Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well? The current status of the mycotoxin definition revealed a lack of consistency, leading to confusion about what compounds should be called mycotoxins. Because this is of pivotal importance in risk assessment prioritization, a clear and quantitatively expressed mycotoxin definition is proposed, based upon data of widely accepted mycotoxins. Finally, this definition is applied to a set of fungal cyclic depsipeptides, revealing that some of these should indeed be considered as mycotoxins.
Keywords
cyclic depsipeptides, toxicity, mycotoxins, definition, hazard, risk, MARINE-DERIVED FUNGUS, PERFORMANCE LIQUID-CHROMATOGRAPHY, INTESTINAL EPITHELIAL-CELLS, TANDEM MASS-SPECTROMETRY, FUSARIUM-MYCOTOXINS, IN-VITRO, BIOLOGICAL-PROPERTIES, ORAL BIOAVAILABILITY, PENICILLIUM-BREVICOMPACTUM, CYTOTOXIC METABOLITES

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MLA
Taevernier, Lien et al. “The Mycotoxin Definition Reconsidered Towards Fungal Cyclic Depsipeptides.” JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS 34.2 (2016): 114–135. Print.
APA
Taevernier, L., Wynendaele, E., De Vreese, L., Burvenich, C., & De Spiegeleer, B. (2016). The mycotoxin definition reconsidered towards fungal cyclic depsipeptides. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, 34(2), 114–135.
Chicago author-date
Taevernier, Lien, Evelien Wynendaele, Leen De Vreese, Christian Burvenich, and Bart De Spiegeleer. 2016. “The Mycotoxin Definition Reconsidered Towards Fungal Cyclic Depsipeptides.” Journal of Environmental Science and Health Part C-environmental Carcinogenesis & Ecotoxicology Reviews 34 (2): 114–135.
Chicago author-date (all authors)
Taevernier, Lien, Evelien Wynendaele, Leen De Vreese, Christian Burvenich, and Bart De Spiegeleer. 2016. “The Mycotoxin Definition Reconsidered Towards Fungal Cyclic Depsipeptides.” Journal of Environmental Science and Health Part C-environmental Carcinogenesis & Ecotoxicology Reviews 34 (2): 114–135.
Vancouver
1.
Taevernier L, Wynendaele E, De Vreese L, Burvenich C, De Spiegeleer B. The mycotoxin definition reconsidered towards fungal cyclic depsipeptides. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS. 2016;34(2):114–35.
IEEE
[1]
L. Taevernier, E. Wynendaele, L. De Vreese, C. Burvenich, and B. De Spiegeleer, “The mycotoxin definition reconsidered towards fungal cyclic depsipeptides,” JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, vol. 34, no. 2, pp. 114–135, 2016.
@article{7142565,
  abstract     = {Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well? The current status of the mycotoxin definition revealed a lack of consistency, leading to confusion about what compounds should be called mycotoxins. Because this is of pivotal importance in risk assessment prioritization, a clear and quantitatively expressed mycotoxin definition is proposed, based upon data of widely accepted mycotoxins. Finally, this definition is applied to a set of fungal cyclic depsipeptides, revealing that some of these should indeed be considered as mycotoxins.},
  author       = {Taevernier, Lien and Wynendaele, Evelien and De Vreese, Leen and Burvenich, Christian and De Spiegeleer, Bart},
  issn         = {1059-0501},
  journal      = {JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS},
  keywords     = {cyclic depsipeptides,toxicity,mycotoxins,definition,hazard,risk,MARINE-DERIVED FUNGUS,PERFORMANCE LIQUID-CHROMATOGRAPHY,INTESTINAL EPITHELIAL-CELLS,TANDEM MASS-SPECTROMETRY,FUSARIUM-MYCOTOXINS,IN-VITRO,BIOLOGICAL-PROPERTIES,ORAL BIOAVAILABILITY,PENICILLIUM-BREVICOMPACTUM,CYTOTOXIC METABOLITES},
  language     = {eng},
  number       = {2},
  pages        = {114--135},
  title        = {The mycotoxin definition reconsidered towards fungal cyclic depsipeptides},
  url          = {http://dx.doi.org/10.1080/10590501.2016.1164561},
  volume       = {34},
  year         = {2016},
}

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