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Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

(2015) ORGANIC & BIOMOLECULAR CHEMISTRY. 13(9). p.2518-2529
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Abstract
Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.
Keywords
COLORECTAL-CANCER, CONJUGATES SYNTHESIS, SQUAMOUS-CELL CARCINOMA, OVARIAN-CANCER MODEL, TUMOR BLOOD-VESSELS, IN-VITRO, PHTHALOCYANINE TETRASULFONATE, INTERNALIZING MONOCLONAL-ANTIBODIES, GROWTH-FACTOR RECEPTOR, TARGETED PHOTODYNAMIC THERAPY

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Chicago
Pereira, Patricia MR, Barbara Korsak, Bruno Sarmento, Rudolf J Schneider, Rosa Fernandes, and João Tomé. 2015. “Antibodies Armed with Photosensitizers: From Chemical Synthesis to Photobiological Applications.” Organic & Biomolecular Chemistry 13 (9): 2518–2529.
APA
Pereira, Patricia MR, Korsak, B., Sarmento, B., Schneider, R. J., Fernandes, R., & Tomé, J. (2015). Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications. ORGANIC & BIOMOLECULAR CHEMISTRY, 13(9), 2518–2529.
Vancouver
1.
Pereira PM, Korsak B, Sarmento B, Schneider RJ, Fernandes R, Tomé J. Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications. ORGANIC & BIOMOLECULAR CHEMISTRY. 2015;13(9):2518–29.
MLA
Pereira, Patricia MR, Barbara Korsak, Bruno Sarmento, et al. “Antibodies Armed with Photosensitizers: From Chemical Synthesis to Photobiological Applications.” ORGANIC & BIOMOLECULAR CHEMISTRY 13.9 (2015): 2518–2529. Print.
@article{7139915,
  abstract     = {Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.},
  author       = {Pereira, Patricia MR and Korsak, Barbara and Sarmento, Bruno and Schneider, Rudolf J and Fernandes, Rosa and Tom{\'e}, Jo{\~a}o},
  issn         = {1477-0520},
  journal      = {ORGANIC \& BIOMOLECULAR CHEMISTRY},
  keyword      = {COLORECTAL-CANCER,CONJUGATES SYNTHESIS,SQUAMOUS-CELL CARCINOMA,OVARIAN-CANCER MODEL,TUMOR BLOOD-VESSELS,IN-VITRO,PHTHALOCYANINE TETRASULFONATE,INTERNALIZING MONOCLONAL-ANTIBODIES,GROWTH-FACTOR RECEPTOR,TARGETED PHOTODYNAMIC THERAPY},
  language     = {eng},
  number       = {9},
  pages        = {2518--2529},
  title        = {Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications},
  url          = {http://dx.doi.org/10.1039/c4ob02334j},
  volume       = {13},
  year         = {2015},
}

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