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Effect of antimicrobial consumption and production type on antibacterial resistance in the bovine respiratory and digestive tract

(2016) PLOS ONE. 11(1).
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Abstract
The aim of this study was to investigate the relationship between antimicrobial use and the occurrence of antimicrobial resistance in the digestive and respiratory tract in three different production systems of food producing animals. A longitudinal study was set up in 25 Belgian bovine herds (10 dairy, 10 beef, and 5 veal herds) for a 2 year monitoring of antimicrobial susceptibilities in E. coli and Pasteurellaceae retrieved from the rectum and the nasal cavity, respectively. During the first year of observation, the antimicrobial use was prospectively recorded on 15 of these farms (5 of each production type) and transformed into the treatment incidences according to the (animal) defined daily dose (TIADD) and (actually) used daily dose (TIUDD). Antimicrobial resistance rates of 4,174 E. coli (all herds) and 474 Pasteurellaceae (beef and veal herds only) isolates for 12 antimicrobial agents demonstrated large differences between intensively reared veal calves (abundant and inconstant) and more extensively reared dairy and beef cattle (sparse and relatively stable). Using linear mixed effect models, a strong relation was found between antimicrobial treatment incidences and resistance profiles of 1,639 E. coli strains (p< 0.0001) and 309 Pasteurellaceae (p <= 0.012). These results indicate that a high antimicrobial selection pressure, here found to be represented by low dosages of oral prophylactic and therapeutic group medication, converts not only the commensal microbiota from the digestive tract but also the opportunistic pathogenic bacteria in the respiratory tract into reservoirs of multi-resistance.
Keywords
DRUG-USE, FARMS, DAIRY CALVES, FATTENING PIGS, ANTIBIOTIC-RESISTANCE, VEAL CALVES, FECAL ESCHERICHIA-COLI, SUSCEPTIBILITY, BACTERIA, PASTEURELLA

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MLA
Catry, Boudewijn et al. “Effect of Antimicrobial Consumption and Production Type on Antibacterial Resistance in the Bovine Respiratory and Digestive Tract.” PLOS ONE 11.1 (2016): n. pag. Print.
APA
Catry, B., Dewulf, J., Maes, D., Pardon, B., Callens, B., Vanrobaeys, M., Opsomer, G., et al. (2016). Effect of antimicrobial consumption and production type on antibacterial resistance in the bovine respiratory and digestive tract. PLOS ONE, 11(1).
Chicago author-date
Catry, Boudewijn, Jeroen Dewulf, Dominiek Maes, Bart Pardon, Benedicte Callens, Mia Vanrobaeys, Geert Opsomer, Aart de Kruif, and Freddy Haesebrouck. 2016. “Effect of Antimicrobial Consumption and Production Type on Antibacterial Resistance in the Bovine Respiratory and Digestive Tract.” Plos One 11 (1).
Chicago author-date (all authors)
Catry, Boudewijn, Jeroen Dewulf, Dominiek Maes, Bart Pardon, Benedicte Callens, Mia Vanrobaeys, Geert Opsomer, Aart de Kruif, and Freddy Haesebrouck. 2016. “Effect of Antimicrobial Consumption and Production Type on Antibacterial Resistance in the Bovine Respiratory and Digestive Tract.” Plos One 11 (1).
Vancouver
1.
Catry B, Dewulf J, Maes D, Pardon B, Callens B, Vanrobaeys M, et al. Effect of antimicrobial consumption and production type on antibacterial resistance in the bovine respiratory and digestive tract. PLOS ONE. 2016;11(1).
IEEE
[1]
B. Catry et al., “Effect of antimicrobial consumption and production type on antibacterial resistance in the bovine respiratory and digestive tract,” PLOS ONE, vol. 11, no. 1, 2016.
@article{7137949,
  abstract     = {The aim of this study was to investigate the relationship between antimicrobial use and the occurrence of antimicrobial resistance in the digestive and respiratory tract in three different production systems of food producing animals. A longitudinal study was set up in 25 Belgian bovine herds (10 dairy, 10 beef, and 5 veal herds) for a 2 year monitoring of antimicrobial susceptibilities in E. coli and Pasteurellaceae retrieved from the rectum and the nasal cavity, respectively. During the first year of observation, the antimicrobial use was prospectively recorded on 15 of these farms (5 of each production type) and transformed into the treatment incidences according to the (animal) defined daily dose (TIADD) and (actually) used daily dose (TIUDD). Antimicrobial resistance rates of 4,174 E. coli (all herds) and 474 Pasteurellaceae (beef and veal herds only) isolates for 12 antimicrobial agents demonstrated large differences between intensively reared veal calves (abundant and inconstant) and more extensively reared dairy and beef cattle (sparse and relatively stable). Using linear mixed effect models, a strong relation was found between antimicrobial treatment incidences and resistance profiles of 1,639 E. coli strains (p< 0.0001) and 309 Pasteurellaceae (p <= 0.012). These results indicate that a high antimicrobial selection pressure, here found to be represented by low dosages of oral prophylactic and therapeutic group medication, converts not only the commensal microbiota from the digestive tract but also the opportunistic pathogenic bacteria in the respiratory tract into reservoirs of multi-resistance.},
  articleno    = {e0146488},
  author       = {Catry, Boudewijn and Dewulf, Jeroen and Maes, Dominiek and Pardon, Bart and Callens, Benedicte and Vanrobaeys, Mia and Opsomer, Geert and de Kruif, Aart and Haesebrouck, Freddy},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {DRUG-USE,FARMS,DAIRY CALVES,FATTENING PIGS,ANTIBIOTIC-RESISTANCE,VEAL CALVES,FECAL ESCHERICHIA-COLI,SUSCEPTIBILITY,BACTERIA,PASTEURELLA},
  language     = {eng},
  number       = {1},
  pages        = {16},
  title        = {Effect of antimicrobial consumption and production type on antibacterial resistance in the bovine respiratory and digestive tract},
  url          = {http://dx.doi.org/10.1371/journal.pone.0146488},
  volume       = {11},
  year         = {2016},
}

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