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Mycotoxins deoxynivalenol and fumonisins alter the extrinsic component of intestinal barrier in broiler chickens

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Abstract
Deoxynivalenol (DON) and fumonisins (FBs) are secondary metabolites produced by Fusarium fungi that frequently contaminate broiler feed. The aim of this study was to investigate the impact of DON and/or FBs on the intestinal barrier in broiler chickens, more specifically on the mucus layer and antioxidative response to oxidative stress. One-day-old broiler chicks were divided into four groups, each consisting:of eight pens of seven birds each, and were fed for 15 days either a control diet, a DON-contaminated diet (4.6 mg DON/kg feed), a FBs-containinated diet (25.4 mg FB1 + FB2/kg feed), or a DON+FBs-contaminated diet (4.3 mg DON and 22.9 mg FB1 + FB2/kg feed). DON and FBs affected the duodenal mucus layer by suppressing intestinal mucin (MUC) 2 gene expression and altering the mucin monosaccharide composition. Both mycotoxins decreased gene expression of the intestinal zinc transporter (ZnT)-1 and regulated intracellular methionine homeostasis, which are both important for preserving the cell's critical antioxidant activity. Feeding a DON- and/or FBs-coritaminated diet, at concentrations close to the European Union maximum guidance levels (5 mg DON and 20 mg FB1 + FB2/kg feed) changes the intestinal mucus layer and several intestinal epithelial antioxidative mechanisms.
Keywords
fumonisins, deoxynivalenol, intestinal barrier, methionine, mucus, zinc, oxidative stress, PERFORMANCE, B-1, TOXICITY, IN-VIVO, broiler, PIG INTESTINE, EPITHELIAL-CELLS, AMINO-ACIDS, GENE-EXPRESSION, XANTHINE OXIDOREDUCTASE, OXIDATIVE STRESS

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Chicago
Antonissen, Gunther, Filip Van Immerseel, Frank Pasmans, Richard Ducatelle, Geert Janssens, Siegrid De Baere, Konstantinos C Mountzouris, et al. 2015. “Mycotoxins Deoxynivalenol and Fumonisins Alter the Extrinsic Component of Intestinal Barrier in Broiler Chickens.” Journal of Agricultural and Food Chemistry 63 (50): 10846–10855.
APA
Antonissen, G., Van Immerseel, F., Pasmans, F., Ducatelle, R., Janssens, G., De Baere, S., Mountzouris, K. C., et al. (2015). Mycotoxins deoxynivalenol and fumonisins alter the extrinsic component of intestinal barrier in broiler chickens. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(50), 10846–10855.
Vancouver
1.
Antonissen G, Van Immerseel F, Pasmans F, Ducatelle R, Janssens G, De Baere S, et al. Mycotoxins deoxynivalenol and fumonisins alter the extrinsic component of intestinal barrier in broiler chickens. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2015;63(50):10846–55.
MLA
Antonissen, Gunther, Filip Van Immerseel, Frank Pasmans, et al. “Mycotoxins Deoxynivalenol and Fumonisins Alter the Extrinsic Component of Intestinal Barrier in Broiler Chickens.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 63.50 (2015): 10846–10855. Print.
@article{7137838,
  abstract     = {Deoxynivalenol (DON) and fumonisins (FBs) are secondary metabolites produced by Fusarium fungi that frequently contaminate broiler feed. The aim of this study was to investigate the impact of DON and/or FBs on the intestinal barrier in broiler chickens, more specifically on the mucus layer and antioxidative response to oxidative stress. One-day-old broiler chicks were divided into four groups, each consisting:of eight pens of seven birds each, and were fed for 15 days either a control diet, a DON-contaminated diet (4.6 mg DON/kg feed), a FBs-containinated diet (25.4 mg FB1 + FB2/kg feed), or a DON+FBs-contaminated diet (4.3 mg DON and 22.9 mg FB1 + FB2/kg feed). DON and FBs affected the duodenal mucus layer by suppressing intestinal mucin (MUC) 2 gene expression and altering the mucin monosaccharide composition. Both mycotoxins decreased gene expression of the intestinal zinc transporter (ZnT)-1 and regulated intracellular methionine homeostasis, which are both important for preserving the cell's critical antioxidant activity. Feeding a DON- and/or FBs-coritaminated diet, at concentrations close to the European Union maximum guidance levels (5 mg DON and 20 mg FB1 + FB2/kg feed) changes the intestinal mucus layer and several intestinal epithelial antioxidative mechanisms.},
  author       = {Antonissen, Gunther and Van Immerseel, Filip and Pasmans, Frank and Ducatelle, Richard and Janssens, Geert and De Baere, Siegrid and Mountzouris, Konstantinos C and Su, Shengchen and Wong, Eric A and De Meulenaer, Bruno and Verlinden, Marc and Devreese, Mathias and Haesebrouck, Freddy and Novak, Barbara and Dohnal, Ilse and Martel, An and Croubels, Siska},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  language     = {eng},
  number       = {50},
  pages        = {10846--10855},
  title        = {Mycotoxins deoxynivalenol and fumonisins alter the extrinsic component of intestinal barrier in broiler chickens},
  url          = {http://dx.doi.org/10.1021/acs.jafc.5b04119},
  volume       = {63},
  year         = {2015},
}

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