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Optimal number of atlases and label fusion for automatic multi-atlas-based brachial plexus contouring in radiotherapy treatment planning

Joris Van de Velde UGent, Johan Wouters, Tom Vercauteren, Werner De Gersem UGent, Eric Achten UGent, Wilfried De Neve UGent and Tom Van Hoof UGent (2016) RADIATION ONCOLOGY. 11.
abstract
Background: The present study aimed to define the optimal number of atlases for automatic multi-atlas-based brachial plexus (BP) segmentation and to compare Simultaneous Truth and Performance Level Estimation (STAPLE) label fusion with Patch label fusion using the ADMIRE (R) software. The accuracy of the autosegmentations was measured by comparing all of the generated autosegmentations with the anatomically validated gold standard segmentations that were developed using cadavers. Materials and methods: Twelve cadaver computed tomography (CT) atlases were used for automatic multiatlas-based segmentation. To determine the optimal number of atlases, one atlas was selected as a patient and the 11 remaining atlases were registered onto this patient using a deformable image registration algorithm. Next, label fusion was performed by using every possible combination of 2 to 11 atlases, once using STAPLE and once using Patch. This procedure was repeated for every atlas as a patient. The similarity of the generated automatic BP segmentations and the gold standard segmentation was measured by calculating the average Dice similarity (DSC), Jaccard (JI) and True positive rate (TPR) for each number of atlases. These similarity indices were compared for the different number of atlases using an equivalence trial and for the two label fusion groups using an independent sample-t test. Results: DSC's and JI's were highest when using nine atlases with both STAPLE (average DSC = 0,532; JI = 0,369) and Patch (average DSC = 0,530; JI = 0,370). When comparing both label fusion algorithms using 9 atlases for both, DSC and JI values were not significantly different. However, significantly higher TPR values were achieved in favour of STAPLE (p < 0,001). When fewer than four atlases were used, STAPLE produced significantly lower DSC, JI and TPR values than did Patch (p = 0,0048). Conclusions: Using 9 atlases with STAPLE label fusion resulted in the most accurate BP autosegmentations (average DSC = 0,532; JI = 0,369 and TPR = 0,760). Only when using fewer than four atlases did the Patch label fusion results in a significantly more accurate autosegmentation than STAPLE.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Multi-atlas-based, Automatic, Brachial plexus, Segmentation, Label fusion, Cadavers, HEAD-AND-NECK, MODULATED RADIATION-THERAPY, SEGMENTATION, CANCER, ACCURACY, ORGANS, RISK, AUTOSEGMENTATION, DELINEATION, VALIDATION
journal title
RADIATION ONCOLOGY
Radiat. Oncol.
volume
11
article number
1
pages
9 pages
Web of Science type
Article
Web of Science id
000367795500001
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.568 (2016)
JCR rank
38/126 (2016)
JCR quartile
2 (2016)
ISSN
1748-717X
DOI
10.1186/s13014-015-0579-1
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
7124576
handle
http://hdl.handle.net/1854/LU-7124576
date created
2016-03-01 12:39:13
date last changed
2017-03-07 09:20:10
@article{7124576,
  abstract     = {Background: The present study aimed to define the optimal number of atlases for automatic multi-atlas-based brachial plexus (BP) segmentation and to compare Simultaneous Truth and Performance Level Estimation (STAPLE) label fusion with Patch label fusion using the ADMIRE (R) software. The accuracy of the autosegmentations was measured by comparing all of the generated autosegmentations with the anatomically validated gold standard segmentations that were developed using cadavers. 
Materials and methods: Twelve cadaver computed tomography (CT) atlases were used for automatic multiatlas-based segmentation. To determine the optimal number of atlases, one atlas was selected as a patient and the 11 remaining atlases were registered onto this patient using a deformable image registration algorithm. Next, label fusion was performed by using every possible combination of 2 to 11 atlases, once using STAPLE and once using Patch. This procedure was repeated for every atlas as a patient. 
The similarity of the generated automatic BP segmentations and the gold standard segmentation was measured by calculating the average Dice similarity (DSC), Jaccard (JI) and True positive rate (TPR) for each number of atlases. These similarity indices were compared for the different number of atlases using an equivalence trial and for the two label fusion groups using an independent sample-t test. 
Results: DSC's and JI's were highest when using nine atlases with both STAPLE (average DSC = 0,532; JI = 0,369) and Patch (average DSC = 0,530; JI = 0,370). When comparing both label fusion algorithms using 9 atlases for both, DSC and JI values were not significantly different. However, significantly higher TPR values were achieved in favour of STAPLE (p {\textlangle} 0,001). When fewer than four atlases were used, STAPLE produced significantly lower DSC, JI and TPR values than did Patch (p = 0,0048). 
Conclusions: Using 9 atlases with STAPLE label fusion resulted in the most accurate BP autosegmentations (average DSC = 0,532; JI = 0,369 and TPR = 0,760). Only when using fewer than four atlases did the Patch label fusion results in a significantly more accurate autosegmentation than STAPLE.},
  articleno    = {1},
  author       = {Van de Velde, Joris and Wouters, Johan and Vercauteren, Tom and De Gersem, Werner and Achten, Eric and De Neve, Wilfried and Van Hoof, Tom},
  issn         = {1748-717X},
  journal      = {RADIATION ONCOLOGY},
  keyword      = {Multi-atlas-based,Automatic,Brachial plexus,Segmentation,Label fusion,Cadavers,HEAD-AND-NECK,MODULATED RADIATION-THERAPY,SEGMENTATION,CANCER,ACCURACY,ORGANS,RISK,AUTOSEGMENTATION,DELINEATION,VALIDATION},
  language     = {eng},
  pages        = {9},
  title        = {Optimal number of atlases and label fusion for automatic multi-atlas-based brachial plexus contouring in radiotherapy treatment planning},
  url          = {http://dx.doi.org/10.1186/s13014-015-0579-1},
  volume       = {11},
  year         = {2016},
}

Chicago
Van de Velde, Joris, Johan Wouters, TOM VERCAUTEREN, Werner De Gersem, Eric Achten, Wilfried De Neve, and Tom Van Hoof. 2016. “Optimal Number of Atlases and Label Fusion for Automatic Multi-atlas-based Brachial Plexus Contouring in Radiotherapy Treatment Planning.” Radiation Oncology 11.
APA
Van de Velde, Joris, Wouters, J., VERCAUTEREN, T., De Gersem, W., Achten, E., De Neve, W., & Van Hoof, T. (2016). Optimal number of atlases and label fusion for automatic multi-atlas-based brachial plexus contouring in radiotherapy treatment planning. RADIATION ONCOLOGY, 11.
Vancouver
1.
Van de Velde J, Wouters J, VERCAUTEREN T, De Gersem W, Achten E, De Neve W, et al. Optimal number of atlases and label fusion for automatic multi-atlas-based brachial plexus contouring in radiotherapy treatment planning. RADIATION ONCOLOGY. 2016;11.
MLA
Van de Velde, Joris, Johan Wouters, TOM VERCAUTEREN, et al. “Optimal Number of Atlases and Label Fusion for Automatic Multi-atlas-based Brachial Plexus Contouring in Radiotherapy Treatment Planning.” RADIATION ONCOLOGY 11 (2016): n. pag. Print.