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Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats

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Abstract
Radioiodine therapy is commonly used in hyperthyroid cats and has a high success rate, ranging from 85-95%. As in humans, thyroid volume has been reported to influence radioiodine therapy outcome in hyperthyroid cats. The purpose of this study was to relate total thyroid volume, calculated by a newly constructed formula for feline patients (0.438 x length x width(2)), to the outcome of radioiodine therapy. To search for a correlation between total thyroid volume and therapy outcome, 167 hyperthyroid cats were included. Patients were categorised according to the administered radioiodine dose and therapy outcome. Our analysis did not show a significant relationship between an increasing total thyroid volume and the odds for a final low total thyroxine concentration (TT4; P = 0.3930) or a final hyperthyroid outcome (P = 0.0901). A significant relationship was found for an increase in the odds for a final low TT4 outcome with an increase in the number of foci detected on the pertechnetate thyroid scan (P = 0.0238). This was not true for a final hyperthyroid outcome (P = 0.7435). The number of detected foci was also significantly associated with the total thyroid volume (P = 0.0006). Findings indicated that the presence of multiple affected foci influences therapy outcome towards a low TT4 outcome. Bilateral hyperthyroidism and its potential effect on a final low TT4 outcome should therefore be addressed when informing owners of the possible outcomes of radioiodine therapy for their cat.
Keywords
GRAVES-DISEASE, RADIOACTIVE IODINE TREATMENT, FELINE HYPERTHYROIDISM, RENAL-FUNCTION, THYROXINE CONCENTRATIONS, PREDICTIVE FACTORS, FOLLOW-UP, HYPOTHYROIDISM, PRETREATMENT, I-131 THERAPY

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Chicago
Volckaert, Veerle, Eva Vandermeulen, André Dobbeleir, Luc Duchateau, Jimmy Saunders, and Kathelijne Peremans. 2016. “Effect of Thyroid Volume on Radioiodine Therapy Outcome in Hyperthyroid Cats.” Journal of Feline Medicine and Surgery 18 (2): 144–149.
APA
Volckaert, V., Vandermeulen, E., Dobbeleir, A., Duchateau, L., Saunders, J., & Peremans, K. (2016). Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats. JOURNAL OF FELINE MEDICINE AND SURGERY, 18(2), 144–149.
Vancouver
1.
Volckaert V, Vandermeulen E, Dobbeleir A, Duchateau L, Saunders J, Peremans K. Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats. JOURNAL OF FELINE MEDICINE AND SURGERY. 2016;18(2):144–9.
MLA
Volckaert, Veerle, Eva Vandermeulen, André Dobbeleir, et al. “Effect of Thyroid Volume on Radioiodine Therapy Outcome in Hyperthyroid Cats.” JOURNAL OF FELINE MEDICINE AND SURGERY 18.2 (2016): 144–149. Print.
@article{7106022,
  abstract     = {Radioiodine therapy is commonly used in hyperthyroid cats and has a high success rate, ranging from 85-95\%. As in humans, thyroid volume has been reported to influence radioiodine therapy outcome in hyperthyroid cats. The purpose of this study was to relate total thyroid volume, calculated by a newly constructed formula for feline patients (0.438 x length x width(2)), to the outcome of radioiodine therapy. To search for a correlation between total thyroid volume and therapy outcome, 167 hyperthyroid cats were included. Patients were categorised according to the administered radioiodine dose and therapy outcome. Our analysis did not show a significant relationship between an increasing total thyroid volume and the odds for a final low total thyroxine concentration (TT4; P = 0.3930) or a final hyperthyroid outcome (P = 0.0901). A significant relationship was found for an increase in the odds for a final low TT4 outcome with an increase in the number of foci detected on the pertechnetate thyroid scan (P = 0.0238). This was not true for a final hyperthyroid outcome (P = 0.7435). The number of detected foci was also significantly associated with the total thyroid volume (P = 0.0006). Findings indicated that the presence of multiple affected foci influences therapy outcome towards a low TT4 outcome. Bilateral hyperthyroidism and its potential effect on a final low TT4 outcome should therefore be addressed when informing owners of the possible outcomes of radioiodine therapy for their cat.},
  author       = {Volckaert, Veerle and Vandermeulen, Eva and Dobbeleir, Andr{\'e} and Duchateau, Luc and Saunders, Jimmy and Peremans, Kathelijne},
  issn         = {1098-612X},
  journal      = {JOURNAL OF FELINE MEDICINE AND SURGERY},
  keyword      = {GRAVES-DISEASE,RADIOACTIVE IODINE TREATMENT,FELINE HYPERTHYROIDISM,RENAL-FUNCTION,THYROXINE CONCENTRATIONS,PREDICTIVE FACTORS,FOLLOW-UP,HYPOTHYROIDISM,PRETREATMENT,I-131 THERAPY},
  language     = {eng},
  number       = {2},
  pages        = {144--149},
  title        = {Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats},
  url          = {http://dx.doi.org/10.1177/1098612X15576587},
  volume       = {18},
  year         = {2016},
}

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