Advanced search
1 file | 2.83 MB Add to list

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

(2016) ANTIVIRAL RESEARCH. 126. p.69-80
Author
Organization
Abstract
Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFN alpha)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections.
Keywords
Innate immunity, Immune responses, Antiviral agents, Influenza A virus, Virus-host interaction, INFLUENZA-A-VIRUS, NS1 PROTEIN, HUMAN MACROPHAGES, RNA-BINDING, NEURAMINIDASE INHIBITORS, PYRIMIDINE BIOSYNTHESIS, ANTIVIRAL RESPONSES, VIRAL-INFECTIONS, EPITHELIAL-CELLS, GENE-EXPRESSION

Downloads

  • 2566 15Soderholm.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 2.83 MB

Citation

Please use this url to cite or link to this publication:

MLA
Söderholm, Sandra et al. “Immuno-modulating Properties of Saliphenylhalamide, SNS-032, Obatoclax, and Gemcitabine.” ANTIVIRAL RESEARCH 126 (2016): 69–80. Print.
APA
Söderholm, S., Anastasina, M., Islam, M. M., Tynell, J., Poranen, M. M., Bamford, D. H., Stenman, J., et al. (2016). Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine. ANTIVIRAL RESEARCH, 126, 69–80.
Chicago author-date
Söderholm, Sandra, Maria Anastasina, Mohammad Majhural Islam, Janne Tynell, Minna M Poranen, Dennis H Bamford, Jakob Stenman, et al. 2016. “Immuno-modulating Properties of Saliphenylhalamide, SNS-032, Obatoclax, and Gemcitabine.” Antiviral Research 126: 69–80.
Chicago author-date (all authors)
Söderholm, Sandra, Maria Anastasina, Mohammad Majhural Islam, Janne Tynell, Minna M Poranen, Dennis H Bamford, Jakob Stenman, Ilkka Julkunen, Ingrida Šaulienė, Jef K De Brabander, Sampsa Matikainen, Tuula A Nyman, Xavier Saelens, and Denis Kainov. 2016. “Immuno-modulating Properties of Saliphenylhalamide, SNS-032, Obatoclax, and Gemcitabine.” Antiviral Research 126: 69–80.
Vancouver
1.
Söderholm S, Anastasina M, Islam MM, Tynell J, Poranen MM, Bamford DH, et al. Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine. ANTIVIRAL RESEARCH. 2016;126:69–80.
IEEE
[1]
S. Söderholm et al., “Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine,” ANTIVIRAL RESEARCH, vol. 126, pp. 69–80, 2016.
@article{7103207,
  abstract     = {Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFN alpha)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections.},
  author       = {Söderholm, Sandra and Anastasina, Maria and Islam, Mohammad Majhural and Tynell, Janne and Poranen, Minna M and Bamford, Dennis H and Stenman, Jakob and Julkunen, Ilkka and Šaulienė, Ingrida and De Brabander, Jef K and Matikainen, Sampsa and Nyman, Tuula A and Saelens, Xavier and Kainov, Denis},
  issn         = {0166-3542},
  journal      = {ANTIVIRAL RESEARCH},
  keywords     = {Innate immunity,Immune responses,Antiviral agents,Influenza A virus,Virus-host interaction,INFLUENZA-A-VIRUS,NS1 PROTEIN,HUMAN MACROPHAGES,RNA-BINDING,NEURAMINIDASE INHIBITORS,PYRIMIDINE BIOSYNTHESIS,ANTIVIRAL RESPONSES,VIRAL-INFECTIONS,EPITHELIAL-CELLS,GENE-EXPRESSION},
  language     = {eng},
  pages        = {69--80},
  title        = {Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine},
  url          = {http://dx.doi.org/10.1016/j.antiviral.2015.12.011},
  volume       = {126},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: