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Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

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Abstract
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them.
Keywords
TISSUE-RESIDENT MACROPHAGES, HEMATOPOIETIC STEM-CELLS, CARDIAC MACROPHAGES, FETAL MONOCYTES, LIVER, INFLAMMATION, INTESTINE, MICROGLIA, IDENTITY, RECEPTOR

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MLA
Scott, Charlotte, et al. “Bone Marrow-Derived Monocytes Give Rise to Self-Renewing and Fully Differentiated Kupffer Cells.” NATURE COMMUNICATIONS, vol. 7, 2016, doi:10.1038/ncomms10321.
APA
Scott, C., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., … Guilliams, M. (2016). Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. NATURE COMMUNICATIONS, 7. https://doi.org/10.1038/ncomms10321
Chicago author-date
Scott, Charlotte, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, et al. 2016. “Bone Marrow-Derived Monocytes Give Rise to Self-Renewing and Fully Differentiated Kupffer Cells.” NATURE COMMUNICATIONS 7. https://doi.org/10.1038/ncomms10321.
Chicago author-date (all authors)
Scott, Charlotte, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart Lambrecht, Alain Beschin, and Martin Guilliams. 2016. “Bone Marrow-Derived Monocytes Give Rise to Self-Renewing and Fully Differentiated Kupffer Cells.” NATURE COMMUNICATIONS 7. doi:10.1038/ncomms10321.
Vancouver
1.
Scott C, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, et al. Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. NATURE COMMUNICATIONS. 2016;7.
IEEE
[1]
C. Scott et al., “Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells,” NATURE COMMUNICATIONS, vol. 7, 2016.
@article{7102628,
  abstract     = {{Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them.}},
  articleno    = {{10321}},
  author       = {{Scott, Charlotte and Zheng, Fang and De Baetselier, Patrick and Martens, Liesbet and Saeys, Yvan and De Prijck, Sofie and Lippens, Saskia and Abels, Chloé and Schoonooghe, Steve and Raes, Geert and Devoogdt, Nick and Lambrecht, Bart and Beschin, Alain and Guilliams, Martin}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{TISSUE-RESIDENT MACROPHAGES,HEMATOPOIETIC STEM-CELLS,CARDIAC MACROPHAGES,FETAL MONOCYTES,LIVER,INFLAMMATION,INTESTINE,MICROGLIA,IDENTITY,RECEPTOR}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells}},
  url          = {{http://dx.doi.org/10.1038/ncomms10321}},
  volume       = {{7}},
  year         = {{2016}},
}

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