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Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture

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Abstract
Background: Thoracic aortic rupture and aortopulmonary fistulation are rare conditions in horses. It mainly affects Friesian horses. Intrinsic differences in biomechanical properties of the aortic wall might predispose this breed. The biomechanical and biochemical properties of the thoracic aorta were characterized in warmblood horses, unaffected Friesian horses and Friesians with aortic rupture in an attempt to unravel the underlying pathogenesis of aortic rupture in Friesian horses. Samples of the thoracic aorta at the ligamentum arteriosum (LA), mid thoracic aorta (T1) and distal thoracic aorta (T2) were obtained from Friesian horses with aortic rupture (A), nonaffected Friesian (NA) and warmblood horses (WB). The biomechanical properties of these samples were determined using uniaxial tensile and rupture assays. The percentages of collagen and elastin (mg/mg dry weight) were quantified. Results: Data revealed no significant biomechanical nor biochemical differences among the different groups of horses. The distal thoracic aorta displayed an increased stiffness associated with a higher collagen percentage in this area and a higher load-bearing capacity compared to the more proximal segments. Conclusions: Our findings match reported findings in other animal species. Study results did not provide evidence that the predisposition of the Friesian horse breed for aortic rupture can be attributed to altered biomechanical properties of the aortic wall.
Keywords
Aorta, Horse, Rupture, Tensile test, Collagen, Elastin, ELASTIN CONTENT, ARTERIAL-WALL, TISSUE, MECHANICS, PURIFICATION, STRENGTH

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MLA
Saey, Veronique et al. “Biomechanical and Biochemical Properties of the Thoracic Aorta in Warmblood Horses, Friesian Horses, and Friesians with Aortic Rupture.” BMC VETERINARY RESEARCH 11 (2015): n. pag. Print.
APA
Saey, V., Famaey, N., Smoljkic, M., Claeys, E., van Loon, G., Ducatelle, R., Ploeg, M., et al. (2015). Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture. BMC VETERINARY RESEARCH, 11.
Chicago author-date
Saey, Veronique, Nele Famaey, Marija Smoljkic, Erik Claeys, Gunther van Loon, Richard Ducatelle, Margreet Ploeg, et al. 2015. “Biomechanical and Biochemical Properties of the Thoracic Aorta in Warmblood Horses, Friesian Horses, and Friesians with Aortic Rupture.” Bmc Veterinary Research 11.
Chicago author-date (all authors)
Saey, Veronique, Nele Famaey, Marija Smoljkic, Erik Claeys, Gunther van Loon, Richard Ducatelle, Margreet Ploeg, Catherine Delesalle, Andrea Gröne, Luc Duchateau, and Koen Chiers. 2015. “Biomechanical and Biochemical Properties of the Thoracic Aorta in Warmblood Horses, Friesian Horses, and Friesians with Aortic Rupture.” Bmc Veterinary Research 11.
Vancouver
1.
Saey V, Famaey N, Smoljkic M, Claeys E, van Loon G, Ducatelle R, et al. Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture. BMC VETERINARY RESEARCH. 2015;11.
IEEE
[1]
V. Saey et al., “Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture,” BMC VETERINARY RESEARCH, vol. 11, 2015.
@article{7102340,
  abstract     = {Background: Thoracic aortic rupture and aortopulmonary fistulation are rare conditions in horses. It mainly affects Friesian horses. Intrinsic differences in biomechanical properties of the aortic wall might predispose this breed. The biomechanical and biochemical properties of the thoracic aorta were characterized in warmblood horses, unaffected Friesian horses and Friesians with aortic rupture in an attempt to unravel the underlying pathogenesis of aortic rupture in Friesian horses. Samples of the thoracic aorta at the ligamentum arteriosum (LA), mid thoracic aorta (T1) and distal thoracic aorta (T2) were obtained from Friesian horses with aortic rupture (A), nonaffected Friesian (NA) and warmblood horses (WB). The biomechanical properties of these samples were determined using uniaxial tensile and rupture assays. The percentages of collagen and elastin (mg/mg dry weight) were quantified. 
Results: Data revealed no significant biomechanical nor biochemical differences among the different groups of horses. The distal thoracic aorta displayed an increased stiffness associated with a higher collagen percentage in this area and a higher load-bearing capacity compared to the more proximal segments. 
Conclusions: Our findings match reported findings in other animal species. Study results did not provide evidence that the predisposition of the Friesian horse breed for aortic rupture can be attributed to altered biomechanical properties of the aortic wall.},
  articleno    = {285},
  author       = {Saey, Veronique and Famaey, Nele and Smoljkic, Marija and Claeys, Erik and van Loon, Gunther and Ducatelle, Richard and Ploeg, Margreet and Delesalle, Catherine and Gröne, Andrea and Duchateau, Luc and Chiers, Koen},
  issn         = {1746-6148},
  journal      = {BMC VETERINARY RESEARCH},
  keywords     = {Aorta,Horse,Rupture,Tensile test,Collagen,Elastin,ELASTIN CONTENT,ARTERIAL-WALL,TISSUE,MECHANICS,PURIFICATION,STRENGTH},
  language     = {eng},
  pages        = {7},
  title        = {Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture},
  url          = {http://dx.doi.org/10.1186/s12917-015-0597-0},
  volume       = {11},
  year         = {2015},
}

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