Advanced search
1 file | 375.46 KB Add to list

Epidemiology of augmented renal clearance in mixed ICU patients

Jan De Waele (UGent) , Alexander Dumoulin (UGent) , A Janssen and Eric Hoste (UGent)
(2015) MINERVA ANESTESIOLOGICA. 81(10). p.1079-1085
Author
Organization
Abstract
Background. Augmented renal clearance (ARC) or renal hyperfiltration is increasingly reported in intensive care unit (ICU) patients. The goal of this analysis was to study the epidemiology of ARC in a cohort of mixed ICU patients Methods. Single center retrospective cohort study of adult ICU patients (12/2008-2/2010). When data were available, urinary creatinine clearance (CLCR) was calculated for all patients throughout their ICU stay. ARC was defined as a body surface adjusted CLCR >= 130 mL/min/1.73m(2). We sought to study the incidence of ARC and identify patient characteristics associated with ARC. Results. A total of 1081 patients were included in the analysis, generating 4472 ICU patient days. Median age was 62 y (IQR 50-72), and 63% were male. The initial CLCR was 86 (39-151) mL/min and the maximal CLCR was 145 (76-237) mL/min. ARC occurred in 55.8% of patients, and was about as frequent in men and women (37%% vs. 35%%, P=0.73). Patients with ARC were younger (57 vs. 67 years, P<0.001) and were less frequently treated with vasopressors (27% vs. 39%, P<0.01). ARC incidence was 36.6 ARC days per 100 ICU days. ARC throughout the ICU stay occurred in 32.8% of patients. Conclusion. ARC was a frequent finding in this cohort of ICU patients, with more than half of the patient expressing ARC at least once during their ICU stay, and an incidence of 36.6 ARC days/100 patient days.
Keywords
CRITICALLY-ILL PATIENTS, PLASMA CREATININE CONCENTRATIONS, Kidney function test, Critical care, Creatinine, GLOMERULAR-FILTRATION-RATE, CARE-UNIT PATIENTS, CONTINUOUS-INFUSION, INJURY, MEROPENEM, SEPTIC PATIENTS, HYPERFILTRATION

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 375.46 KB

Citation

Please use this url to cite or link to this publication:

MLA
De Waele, Jan et al. “Epidemiology of Augmented Renal Clearance in Mixed ICU Patients.” MINERVA ANESTESIOLOGICA 81.10 (2015): 1079–1085. Print.
APA
De Waele, Jan, Dumoulin, A., Janssen, A., & Hoste, E. (2015). Epidemiology of augmented renal clearance in mixed ICU patients. MINERVA ANESTESIOLOGICA, 81(10), 1079–1085.
Chicago author-date
De Waele, Jan, Alexander Dumoulin, A Janssen, and Eric Hoste. 2015. “Epidemiology of Augmented Renal Clearance in Mixed ICU Patients.” Minerva Anestesiologica 81 (10): 1079–1085.
Chicago author-date (all authors)
De Waele, Jan, Alexander Dumoulin, A Janssen, and Eric Hoste. 2015. “Epidemiology of Augmented Renal Clearance in Mixed ICU Patients.” Minerva Anestesiologica 81 (10): 1079–1085.
Vancouver
1.
De Waele J, Dumoulin A, Janssen A, Hoste E. Epidemiology of augmented renal clearance in mixed ICU patients. MINERVA ANESTESIOLOGICA. 2015;81(10):1079–85.
IEEE
[1]
J. De Waele, A. Dumoulin, A. Janssen, and E. Hoste, “Epidemiology of augmented renal clearance in mixed ICU patients,” MINERVA ANESTESIOLOGICA, vol. 81, no. 10, pp. 1079–1085, 2015.
@article{7101565,
  abstract     = {Background. Augmented renal clearance (ARC) or renal hyperfiltration is increasingly reported in intensive care unit (ICU) patients. The goal of this analysis was to study the epidemiology of ARC in a cohort of mixed ICU patients 
Methods. Single center retrospective cohort study of adult ICU patients (12/2008-2/2010). When data were available, urinary creatinine clearance (CLCR) was calculated for all patients throughout their ICU stay. ARC was defined as a body surface adjusted CLCR >= 130 mL/min/1.73m(2). We sought to study the incidence of ARC and identify patient characteristics associated with ARC. 
Results. A total of 1081 patients were included in the analysis, generating 4472 ICU patient days. Median age was 62 y (IQR 50-72), and 63% were male. The initial CLCR was 86 (39-151) mL/min and the maximal CLCR was 145 (76-237) mL/min. ARC occurred in 55.8% of patients, and was about as frequent in men and women (37%% vs. 35%%, P=0.73). Patients with ARC were younger (57 vs. 67 years, P<0.001) and were less frequently treated with vasopressors (27% vs. 39%, P<0.01). ARC incidence was 36.6 ARC days per 100 ICU days. ARC throughout the ICU stay occurred in 32.8% of patients. 
Conclusion. ARC was a frequent finding in this cohort of ICU patients, with more than half of the patient expressing ARC at least once during their ICU stay, and an incidence of 36.6 ARC days/100 patient days.},
  author       = {De Waele, Jan and Dumoulin, Alexander and Janssen, A and Hoste, Eric},
  issn         = {0375-9393},
  journal      = {MINERVA ANESTESIOLOGICA},
  keywords     = {CRITICALLY-ILL PATIENTS,PLASMA CREATININE CONCENTRATIONS,Kidney function test,Critical care,Creatinine,GLOMERULAR-FILTRATION-RATE,CARE-UNIT PATIENTS,CONTINUOUS-INFUSION,INJURY,MEROPENEM,SEPTIC PATIENTS,HYPERFILTRATION},
  language     = {eng},
  number       = {10},
  pages        = {1079--1085},
  title        = {Epidemiology of augmented renal clearance in mixed ICU patients},
  volume       = {81},
  year         = {2015},
}

Web of Science
Times cited: