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Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics

Philippe B Katchunga, Patrick N Mirindi, Antoine S Kishabongo, Justin C Cikomola, Socrate Bwanamdogo, Jan Philippé (UGent) , Marijn Speeckaert (UGent) and Joris Delanghe (UGent)
(2015) BIOCHEMIA MEDICA. 25(3). p.469-473
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Abstract
Introduction: Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short-and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker. Materials and methods: This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek(R) Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+(R)) were measured at start and after 6 months. Results: ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 mu mol/g nail. Concentration of glycated nail proteins was significantly higher (P < 0.001) in diabetics in comparison with non-diabetics. After 6 months of antidiabetic treatment, a significant drop in the fasting glucose concentration (P = 0.017) and concentration of glycated nail proteins (P = 0.008) was observed in contrast to serum fructosamine and HbA1c. Conclusions: Measurement of glycated nail proteins could be used to diagnose and monitor diabetes mellitus in sub-Saharan Africa.
Keywords
fructosamine, hemoglobin A1c protein, fasting glucose concentration, nails, sub-Saharan Africa, diabetes mellitus, ETHNIC-DIFFERENCES, HEMOGLOBIN, DIAGNOSIS, GLUCOSE, POPULATION, VALIDATION, HBA1C, A1C

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MLA
Katchunga, Philippe B., et al. “Glycated Nail Proteins as a New Biomarker in Management of the South Kivu Congolese Diabetics.” BIOCHEMIA MEDICA, vol. 25, no. 3, 2015, pp. 469–73.
APA
Katchunga, P. B., Mirindi, P. N., Kishabongo, A. S., Cikomola, J. C., Bwanamdogo, S., Philippé, J., … Delanghe, J. (2015). Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics. BIOCHEMIA MEDICA, 25(3), 469–473.
Chicago author-date
Katchunga, Philippe B, Patrick N Mirindi, Antoine S Kishabongo, Justin C Cikomola, Socrate Bwanamdogo, Jan Philippé, Marijn Speeckaert, and Joris Delanghe. 2015. “Glycated Nail Proteins as a New Biomarker in Management of the South Kivu Congolese Diabetics.” BIOCHEMIA MEDICA 25 (3): 469–73.
Chicago author-date (all authors)
Katchunga, Philippe B, Patrick N Mirindi, Antoine S Kishabongo, Justin C Cikomola, Socrate Bwanamdogo, Jan Philippé, Marijn Speeckaert, and Joris Delanghe. 2015. “Glycated Nail Proteins as a New Biomarker in Management of the South Kivu Congolese Diabetics.” BIOCHEMIA MEDICA 25 (3): 469–473.
Vancouver
1.
Katchunga PB, Mirindi PN, Kishabongo AS, Cikomola JC, Bwanamdogo S, Philippé J, et al. Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics. BIOCHEMIA MEDICA. 2015;25(3):469–73.
IEEE
[1]
P. B. Katchunga et al., “Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics,” BIOCHEMIA MEDICA, vol. 25, no. 3, pp. 469–473, 2015.
@article{7099895,
  abstract     = {{Introduction: Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short-and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker. 
Materials and methods: This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek(R) Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+(R)) were measured at start and after 6 months. 
Results: ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 mu mol/g nail. Concentration of glycated nail proteins was significantly higher (P < 0.001) in diabetics in comparison with non-diabetics. After 6 months of antidiabetic treatment, a significant drop in the fasting glucose concentration (P = 0.017) and concentration of glycated nail proteins (P = 0.008) was observed in contrast to serum fructosamine and HbA1c. 
Conclusions: Measurement of glycated nail proteins could be used to diagnose and monitor diabetes mellitus in sub-Saharan Africa.}},
  author       = {{Katchunga, Philippe B and Mirindi, Patrick N and Kishabongo, Antoine S and Cikomola, Justin C and Bwanamdogo, Socrate and Philippé, Jan and Speeckaert, Marijn and Delanghe, Joris}},
  issn         = {{1330-0962}},
  journal      = {{BIOCHEMIA MEDICA}},
  keywords     = {{fructosamine,hemoglobin A1c protein,fasting glucose concentration,nails,sub-Saharan Africa,diabetes mellitus,ETHNIC-DIFFERENCES,HEMOGLOBIN,DIAGNOSIS,GLUCOSE,POPULATION,VALIDATION,HBA1C,A1C}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{469--473}},
  title        = {{Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics}},
  volume       = {{25}},
  year         = {{2015}},
}
Web of Science
Times cited: