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In vitro antistaphylococcal effects of Embelia schimperi extracts and their component embelin with oxacillin and tetracycline

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Abstract
Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants. Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species. In the present study, we examined two extracts prepared from seeds and twigs with leaves of E. schimperi and its main present secondary metabolite embelin for their antibacterial combinatory effect with oxacillin and tetracycline against sensitive and resistant Staphylococcus aureus strains. Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated through fractional inhibitory concentration sum (Sigma FIC) indices. Results show many positive interactions and synergy occurring in embelin and oxacillin combinations against 4 out of 9 strains (Sigma FIC 0.203-0.477) and for embelin and tetracycline combination against 3 out of 9 strains (Sigma FIC 0.400-0.496). Moreover, the resistance to oxacillin has been overcome in 2 strains and to tetracycline in 3 strains. According to our knowledge, this is the first study showing antimicrobial combinatory effect of E. schimperi as well as of embelin. These findings can be used for the further research targeted on the development of new antistaphylococcal agents.
Keywords
ANTIMICROBIAL ACTIVITY, STAPHYLOCOCCUS-AUREUS, MEDICINAL-PLANTS, RESISTANCE, ANTIBACTERIAL, ANTIBIOTICS, KNOWLEDGE, TOXICITY, PRODUCTS, ETHIOPIA

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Chicago
Rondevaldova, Johana, Olga Leuner, Alemtshay Teka Sahile, Ermias Lulekal, Jaroslav Havlik, Patrick Van Damme, and Ladislav Kokoska. 2015. “In Vitro Antistaphylococcal Effects of Embelia Schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline.” Evidence-based Complementary and Alternative Medicine.
APA
Rondevaldova, J., Leuner, O., Teka Sahile, A., Lulekal, E., Havlik, J., Van Damme, P., & Kokoska, L. (2015). In vitro antistaphylococcal effects of Embelia schimperi extracts and their component embelin with oxacillin and tetracycline. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
Vancouver
1.
Rondevaldova J, Leuner O, Teka Sahile A, Lulekal E, Havlik J, Van Damme P, et al. In vitro antistaphylococcal effects of Embelia schimperi extracts and their component embelin with oxacillin and tetracycline. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2015;
MLA
Rondevaldova, Johana, Olga Leuner, Alemtshay Teka Sahile, et al. “In Vitro Antistaphylococcal Effects of Embelia Schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline.” EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015): n. pag. Print.
@article{7097170,
  abstract     = {Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants. Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species. In the present study, we examined two extracts prepared from seeds and twigs with leaves of E. schimperi and its main present secondary metabolite embelin for their antibacterial combinatory effect with oxacillin and tetracycline against sensitive and resistant Staphylococcus aureus strains. Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated through fractional inhibitory concentration sum (Sigma FIC) indices. Results show many positive interactions and synergy occurring in embelin and oxacillin combinations against 4 out of 9 strains (Sigma FIC 0.203-0.477) and for embelin and tetracycline combination against 3 out of 9 strains (Sigma FIC 0.400-0.496). Moreover, the resistance to oxacillin has been overcome in 2 strains and to tetracycline in 3 strains. According to our knowledge, this is the first study showing antimicrobial combinatory effect of E. schimperi as well as of embelin. These findings can be used for the further research targeted on the development of new antistaphylococcal agents.},
  articleno    = {175983},
  author       = {Rondevaldova, Johana and Leuner, Olga and Teka Sahile, Alemtshay and Lulekal, Ermias and Havlik, Jaroslav and Van Damme, Patrick and Kokoska, Ladislav},
  issn         = {1741-427X},
  journal      = {EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE},
  language     = {eng},
  pages        = {7},
  title        = {In vitro antistaphylococcal effects of Embelia schimperi extracts and their component embelin with oxacillin and tetracycline},
  url          = {http://dx.doi.org/10.1155/2015/175983},
  year         = {2015},
}

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