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Successful antiparasitic treatment for cysticercosis is associated with a fast and marked reduction of circulating antigen levels in a naturally infected pig model

Author
Organization
Project
Bill and Melinda Gates Foundation
Project
Fogarty International Center/NIH
Abstract
Taenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic pigs, which received different regimes of antiparasitic drugs (N = 39, 7 groups), prednisone (N = 5), or controls (N = 6). Samples were collected from baseline to week 10 after treatment, when pigs were euthanized and carefully dissected at necropsy. Antigen levels decreased proportionally to the efficacy of treatment and correlated with the remaining viable cysts at necropsy (Pearson's p = 0.67, P = 0.000). A decrease of 5 times in antigen levels (logarithmic scale) compared with baseline was found in 20/26 pigs free of cysts at necropsy, compared with 1/24 of those who had persisting viable cysts (odds ratio [OR] = 76.7, 95% confidence interval [CI] = 8.1-3308.6, P < 0.001). Antigen monitoring reflects the course of infection in the pig. If a similar correlation exists in infected humans, this assay may provide a minimally invasive and easy monitoring assay to assess disease evolution and efficacy of antiparasitic treatment in human neurocysticercosis.
Keywords
TAENIA-SAGINATA CYSTICERCOSIS, DIAGNOSIS, CEREBROSPINAL-FLUID, HP10 ANTIGEN, INTRAVENTRICULAR HUMAN NEUROCYSTICERCOSIS, IN-FIELD CONDITIONS, LINKED IMMUNOELECTROTRANSFER BLOT, PORCINE CYSTICERCOSIS, FOLLOW-UP, SOLIUM CYSTICERCOSIS

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Citation

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Chicago
Gonzalez, Armando E, Javier A Bustos, Hector H Garcia, Silvia Rodriguez, Mirko Zimic, Yesenia Castillo, Nicolas Praet, Sarah Gabriël, Robert H Gilman, and Pierre Dorny. 2015. “Successful Antiparasitic Treatment for Cysticercosis Is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model.” American Journal of Tropical Medicine and Hygiene 93 (6): 1305–1310.
APA
Gonzalez, A. E., Bustos, J. A., Garcia, H. H., Rodriguez, S., Zimic, M., Castillo, Y., Praet, N., et al. (2015). Successful antiparasitic treatment for cysticercosis is associated with a fast and marked reduction of circulating antigen levels in a naturally infected pig model. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 93(6), 1305–1310.
Vancouver
1.
Gonzalez AE, Bustos JA, Garcia HH, Rodriguez S, Zimic M, Castillo Y, et al. Successful antiparasitic treatment for cysticercosis is associated with a fast and marked reduction of circulating antigen levels in a naturally infected pig model. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015;93(6):1305–10.
MLA
Gonzalez, Armando E, Javier A Bustos, Hector H Garcia, et al. “Successful Antiparasitic Treatment for Cysticercosis Is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model.” AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 93.6 (2015): 1305–1310. Print.
@article{7093272,
  abstract     = {Taenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic pigs, which received different regimes of antiparasitic drugs (N = 39, 7 groups), prednisone (N = 5), or controls (N = 6). Samples were collected from baseline to week 10 after treatment, when pigs were euthanized and carefully dissected at necropsy. Antigen levels decreased proportionally to the efficacy of treatment and correlated with the remaining viable cysts at necropsy (Pearson's p = 0.67, P = 0.000). A decrease of 5 times in antigen levels (logarithmic scale) compared with baseline was found in 20/26 pigs free of cysts at necropsy, compared with 1/24 of those who had persisting viable cysts (odds ratio [OR] = 76.7, 95\% confidence interval [CI] = 8.1-3308.6, P {\textlangle} 0.001). Antigen monitoring reflects the course of infection in the pig. If a similar correlation exists in infected humans, this assay may provide a minimally invasive and easy monitoring assay to assess disease evolution and efficacy of antiparasitic treatment in human neurocysticercosis.},
  author       = {Gonzalez, Armando E and Bustos, Javier A and Garcia, Hector H and Rodriguez, Silvia and Zimic, Mirko and Castillo, Yesenia and Praet, Nicolas and Gabri{\"e}l, Sarah and Gilman, Robert H and Dorny, Pierre},
  issn         = {0002-9637},
  journal      = {AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE},
  keyword      = {TAENIA-SAGINATA CYSTICERCOSIS,DIAGNOSIS,CEREBROSPINAL-FLUID,HP10 ANTIGEN,INTRAVENTRICULAR HUMAN NEUROCYSTICERCOSIS,IN-FIELD CONDITIONS,LINKED IMMUNOELECTROTRANSFER BLOT,PORCINE CYSTICERCOSIS,FOLLOW-UP,SOLIUM CYSTICERCOSIS},
  language     = {eng},
  number       = {6},
  pages        = {1305--1310},
  title        = {Successful antiparasitic treatment for cysticercosis is associated with a fast and marked reduction of circulating antigen levels in a naturally infected pig model},
  url          = {http://dx.doi.org/10.4269/ajtmh.15-0370},
  volume       = {93},
  year         = {2015},
}

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