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Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD ) : study protocol for establishing a core outcome set in haemodialysis

(2015) TRIALS. 16.
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Abstract
Background: Chronic kidney disease is a significant contributor to mortality and morbidity worldwide, and the number of people who require dialysis or transplantation continues to increase. People on dialysis are 15 times more likely to die than the general population. Dialysis is also costly, intrusive, and time-consuming and imposes an enormous burden on patients and their families. This escalating problem has spurred a proliferation of trials in dialysis, yet health and quality of life remain poor. The reasons for this are complex and varied but are attributable in part to problems in the design and reporting of studies, particularly outcome selection. Problems related to outcomes include use of unvalidated surrogates, outcomes of little or no relevance to patients, highly variable outcome selection limiting comparability across studies, and bias in reporting outcomes. The aim of the Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD) study is to establish a core outcome set for haemodialysis trials, to improve the quality of reporting, and the relevance of trials conducted in people on haemodialysis. Methods/design: SONG-HD is a five-phase project that includes the following: a systematic review to identify outcomes that have been reported in haemodialysis systematic reviews and trials; nominal group technique with patients and caregivers to identify, rank, and describe reasons for their choices; qualitative stakeholder interviews with patients, caregivers, clinicians, researchers, and policy makers to elicit individual values and perspectives on outcomes for haemodialysis trials; a three-round Delphi survey with stakeholder groups to distil and generate a prioritised list of core outcomes; and a consensus workshop to establish a core outcome set for haemodialysis trials. Discussion: Establishing a core outcome set to be consistently measured and reported in haemodialysis trials will improve the integrity, transparency, usability, and contribution of research relevant to patients requiring haemodialysis; ensure that outcomes of relevance to all stakeholders are consistently reported across trials; and mitigate against outcome reporting bias. Ultimately, patients will be more protected from potential harm, patients and clinicians will be better able to make informed decisions about treatment, and researchers and policy makers will be more able to maximise the value of research to the public.
Keywords
CLINICAL-TRIALS, RESEARCH PRIORITIES, QUALITY-OF-LIFE, CHRONIC KIDNEY-DISEASE, NOMINAL GROUP, REPORTING BIAS, HEALTH RESEARCH, SYSTEMATIC REVIEWS, THEMATIC SYNTHESIS, FAMILY CAREGIVERS, Chronic kidney disease, Haemodialysis, Patient-centred outcomes clinical trials, Outcomes research, Core outcome set, Dialysis

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Citation

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Chicago
Tong, Allison, Braden Manns, Brenda Hemmelgarn, David C Wheeler, Peter Tugwell, Wolfgang C Winkelmayer, Wim Van Biesen, et al. 2015. “Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD ) : Study Protocol for Establishing a Core Outcome Set in Haemodialysis.” Trials 16.
APA
Tong, A., Manns, B., Hemmelgarn, B., Wheeler, D. C., Tugwell, P., Winkelmayer, W. C., Van Biesen, W., et al. (2015). Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD ) : study protocol for establishing a core outcome set in haemodialysis. TRIALS, 16.
Vancouver
1.
Tong A, Manns B, Hemmelgarn B, Wheeler DC, Tugwell P, Winkelmayer WC, et al. Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD ) : study protocol for establishing a core outcome set in haemodialysis. TRIALS. 2015;16.
MLA
Tong, Allison, Braden Manns, Brenda Hemmelgarn, et al. “Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD ) : Study Protocol for Establishing a Core Outcome Set in Haemodialysis.” TRIALS 16 (2015): n. pag. Print.
@article{7088899,
  abstract     = {Background: Chronic kidney disease is a significant contributor to mortality and morbidity worldwide, and the number of people who require dialysis or transplantation continues to increase. People on dialysis are 15 times more likely to die than the general population. Dialysis is also costly, intrusive, and time-consuming and imposes an enormous burden on patients and their families. This escalating problem has spurred a proliferation of trials in dialysis, yet health and quality of life remain poor. The reasons for this are complex and varied but are attributable in part to problems in the design and reporting of studies, particularly outcome selection. Problems related to outcomes include use of unvalidated surrogates, outcomes of little or no relevance to patients, highly variable outcome selection limiting comparability across studies, and bias in reporting outcomes. The aim of the Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD) study is to establish a core outcome set for haemodialysis trials, to improve the quality of reporting, and the relevance of trials conducted in people on haemodialysis. 
Methods/design: SONG-HD is a five-phase project that includes the following: a systematic review to identify outcomes that have been reported in haemodialysis systematic reviews and trials; nominal group technique with patients and caregivers to identify, rank, and describe reasons for their choices; qualitative stakeholder interviews with patients, caregivers, clinicians, researchers, and policy makers to elicit individual values and perspectives on outcomes for haemodialysis trials; a three-round Delphi survey with stakeholder groups to distil and generate a prioritised list of core outcomes; and a consensus workshop to establish a core outcome set for haemodialysis trials. 
Discussion: Establishing a core outcome set to be consistently measured and reported in haemodialysis trials will improve the integrity, transparency, usability, and contribution of research relevant to patients requiring haemodialysis; ensure that outcomes of relevance to all stakeholders are consistently reported across trials; and mitigate against outcome reporting bias. Ultimately, patients will be more protected from potential harm, patients and clinicians will be better able to make informed decisions about treatment, and researchers and policy makers will be more able to maximise the value of research to the public.},
  articleno    = {364},
  author       = {Tong, Allison and Manns, Braden and Hemmelgarn, Brenda and Wheeler, David C and Tugwell, Peter and Winkelmayer, Wolfgang C and Van Biesen, Wim and Crowe, Sally and Kerr, Peter G and Polkinghorne, Kevan R and Howard, Kirsten and Pollock, Carol and Hawley, Carmel M and Johnson, David W and McDonald, Stephen P and Gallagher, Martin P and Urquhart-Secord, Rachel and Craig, Jonathan C},
  issn         = {1745-6215},
  journal      = {TRIALS},
  language     = {eng},
  pages        = {9},
  title        = {Standardised Outcomes in Nephrology-Haemodialysis (SONG-HD ) : study protocol for establishing a core outcome set in haemodialysis},
  url          = {http://dx.doi.org/10.1186/s13063-015-0895-7},
  volume       = {16},
  year         = {2015},
}

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