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Epidemiology, impact and control of rabies in Nepal : a systematic review

Brecht Devleesschauwer, Arjun Aryal, Barun Kumar Sharma, Anita Ale, Anne Declercq, Stephanie Depraz, Tara Nath Gaire, Gyanendra Gongal, Surendra Karki, Basu Dev Pandey, et al. (2016) PLOS NEGLECTED TROPICAL DISEASES. 10(2).
abstract
Background: Rabies is a vaccine-preventable viral zoonosis belonging to the group of neglected tropical diseases. Exposure to a rabid animal may result in a fatal acute encephalitis if effective post-exposure prophylaxis is not provided. Rabies occurs worldwide, but its burden is disproportionately high in developing countries, including Nepal. We aimed to summarize current knowledge on the epidemiology, impact and control of rabies in Nepal. Methods: We performed a systematic review of international and national scientific literature and searched grey literature through the World Health Organization Digital Library and the library of the National Zoonoses and Food Hygiene Research Centre, Nepal, and through searching Google and Google Scholar. Further data on animal and human rabies were obtained from the relevant Nepalese government agencies. Finally, we surveyed the archives of a Nepalese daily to obtain qualitative information on rabies in Nepal. Findings: So far, only little original research has been conducted on the epidemiology and impact of rabies in Nepal. Per year, rabies is reported to kill about 100 livestock and 10–100 humans, while about 1,000 livestock and 35,000 humans are reported to receive rabies post-exposure prophylaxis. However, these estimates are very likely to be serious underestimations of the true rabies burden. Significant progress has been made in the production of cell culture-based anti-rabies vaccine and rabies immunoglobulin, but availability and supply remain a matter of concern, especially in remote areas. Different state and non-state actors have initiated rabies control activities over the years, but efforts typically remained focalized, of short duration and not harmonized. Communication and coordination between veterinary and human health authorities is limited at present, further complicating rabies control in Nepal. Important research gaps include the reporting biases for both human and animal rabies, the ecology of stray dog populations and the true contribution of the sylvatic cycle. Interpretation: Better data are needed to unravel the true burden of animal and human rabies. More collaboration, both within the country and within the region, is needed to control rabies. To achieve these goals, high level political commitment is essential. We therefore propose to make rabies the model zoonosis for successful control in Nepal.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
KATHMANDU VALLEY, PREVENTION, TRAVELERS, POPULATIONS, EXPOSURE, DISEASE, BURDEN, VIRUS, JAPAN, BITES
journal title
PLOS NEGLECTED TROPICAL DISEASES
PLoS Neglect. Trop. Dis.
volume
10
issue
2
article number
e0004461
pages
18 pages
Web of Science type
Review
Web of Science id
000372567300066
JCR category
TROPICAL MEDICINE
JCR impact factor
3.834 (2016)
JCR rank
1/19 (2016)
JCR quartile
1 (2016)
ISSN
1935-2735
DOI
10.1371/journal.pntd.0004461
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
7084608
handle
http://hdl.handle.net/1854/LU-7084608
date created
2016-02-13 01:16:12
date last changed
2017-04-18 09:06:50
@article{7084608,
  abstract     = {Background: Rabies is a vaccine-preventable viral zoonosis belonging to the group of neglected tropical diseases. Exposure to a rabid animal may result in a fatal acute encephalitis if effective post-exposure prophylaxis is not provided. Rabies occurs worldwide, but its burden is disproportionately high in developing countries, including Nepal. We aimed to summarize current knowledge on the epidemiology, impact and control of rabies in Nepal.
Methods: We performed a systematic review of international and national scientific literature and searched grey literature through the World Health Organization Digital Library and the library of the National Zoonoses and Food Hygiene Research Centre, Nepal, and through searching Google and Google Scholar. Further data on animal and human rabies were obtained from the relevant Nepalese government agencies. Finally, we surveyed the archives of a Nepalese daily to obtain qualitative information on rabies in Nepal.
Findings: So far, only little original research has been conducted on the epidemiology and impact of rabies in Nepal. Per year, rabies is reported to kill about 100 livestock and 10--100 humans, while about 1,000 livestock and 35,000 humans are reported to receive rabies post-exposure prophylaxis. However, these estimates are very likely to be serious underestimations of the true rabies burden. Significant progress has been made in the production of cell culture-based anti-rabies vaccine and rabies immunoglobulin, but availability and supply remain a matter of concern, especially in remote areas. Different state and non-state actors have initiated rabies control activities over the years, but efforts typically remained focalized, of short duration and not harmonized. Communication and coordination between veterinary and human health authorities is limited at present, further complicating rabies control in Nepal. Important research gaps include the reporting biases for both human and animal rabies, the ecology of stray dog populations and the true contribution of the sylvatic cycle.
Interpretation: Better data are needed to unravel the true burden of animal and human rabies. More collaboration, both within the country and within the region, is needed to control rabies. To achieve these goals, high level political commitment is essential. We therefore propose to make rabies the model zoonosis for successful control in Nepal.},
  articleno    = {e0004461},
  author       = {Devleesschauwer, Brecht and Aryal, Arjun and Sharma, Barun Kumar and Ale, Anita and Declercq, Anne and Depraz, Stephanie and Gaire, Tara Nath and Gongal, Gyanendra and Karki, Surendra and Pandey, Basu Dev and Pun, Sher Bahadur and Duchateau, Luc and Dorny, Pierre and Speybroeck, Niko},
  issn         = {1935-2735},
  journal      = {PLOS NEGLECTED TROPICAL DISEASES},
  keyword      = {KATHMANDU VALLEY,PREVENTION,TRAVELERS,POPULATIONS,EXPOSURE,DISEASE,BURDEN,VIRUS,JAPAN,BITES},
  language     = {eng},
  number       = {2},
  pages        = {18},
  title        = {Epidemiology, impact and control of rabies in Nepal : a systematic review},
  url          = {http://dx.doi.org/10.1371/journal.pntd.0004461},
  volume       = {10},
  year         = {2016},
}

Chicago
Devleesschauwer, Brecht, Arjun Aryal, Barun Kumar Sharma, Anita Ale, Anne Declercq, Stephanie Depraz, Tara Nath Gaire, et al. 2016. “Epidemiology, Impact and Control of Rabies in Nepal : a Systematic Review.” Plos Neglected Tropical Diseases 10 (2).
APA
Devleesschauwer, B., Aryal, A., Sharma, B. K., Ale, A., Declercq, A., Depraz, S., Gaire, T. N., et al. (2016). Epidemiology, impact and control of rabies in Nepal : a systematic review. PLOS NEGLECTED TROPICAL DISEASES, 10(2).
Vancouver
1.
Devleesschauwer B, Aryal A, Sharma BK, Ale A, Declercq A, Depraz S, et al. Epidemiology, impact and control of rabies in Nepal : a systematic review. PLOS NEGLECTED TROPICAL DISEASES. 2016;10(2).
MLA
Devleesschauwer, Brecht, Arjun Aryal, Barun Kumar Sharma, et al. “Epidemiology, Impact and Control of Rabies in Nepal : a Systematic Review.” PLOS NEGLECTED TROPICAL DISEASES 10.2 (2016): n. pag. Print.