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Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs

(2015) ELIFE. 4.
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Abstract
Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-naïve seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.
Keywords
CD4(+) T-CELLS, IMMUNODEFICIENCY-VIRUS TYPE-1, HIV, early treatment, HIV reservoir, ddPCR, digital PCR, acute infection, long term non progressors, elite control, TERMINAL REPEAT CIRCLES, VIRAL PERSISTENCE, IMMUNE ACTIVATION, ELITE CONTROLLERS, INFECTED PATIENTS, DNA, REPLICATION, INTEGRATION

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Chicago
Malatinková, Eva, Ward De Spiegelaere, Pawel Bonczkowski, Maja Kiselinova, Wim Trypsteen, Margaret Johnson, Chris Verhofstede, et al. 2015. “Impact of a Decade of Successful Antiretroviral Therapy Initiated at HIV-1 Seroconversion on Blood and Mucosal Reservoirs.” Elife 4.
APA
Malatinková, E., De Spiegelaere, W., Bonczkowski, P., Kiselinova, M., Trypsteen, W., Johnson, M., Verhofstede, C., et al. (2015). Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs. ELIFE, 4.
Vancouver
1.
Malatinková E, De Spiegelaere W, Bonczkowski P, Kiselinova M, Trypsteen W, Johnson M, et al. Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs. ELIFE. 2015;4.
MLA
Malatinková, Eva, Ward De Spiegelaere, Pawel Bonczkowski, et al. “Impact of a Decade of Successful Antiretroviral Therapy Initiated at HIV-1 Seroconversion on Blood and Mucosal Reservoirs.” ELIFE 4 (2015): n. pag. Print.
@article{7083004,
  abstract     = {Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-na{\"i}ve seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.},
  articleno    = {e09115},
  author       = {Malatinkov{\'a}, Eva and De Spiegelaere, Ward and Bonczkowski, Pawel and Kiselinova, Maja and Trypsteen, Wim and Johnson, Margaret and Verhofstede, Chris and De Looze, Danny and Murray, Charles and Kinloch-de Loes, Sabine and Vandekerckhove, Linos},
  issn         = {2050-084X},
  journal      = {ELIFE},
  language     = {eng},
  pages        = {17},
  title        = {Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs},
  url          = {http://dx.doi.org/10.7554/eLife.09115},
  volume       = {4},
  year         = {2015},
}

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