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Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs

Eva Malatinková UGent, Ward De Spiegelaere UGent, Pawel Bonczkowski UGent, MAJA KISELINOVA, Wim Trypsteen UGent, Margaret Johnson, Chris Verhofstede UGent, Danny De Looze UGent, Charles Murray, Sabine Kinloch-de Loes, et al. (2015) ELIFE. 4.
abstract
Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-naïve seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CD4(+) T-CELLS, IMMUNODEFICIENCY-VIRUS TYPE-1, HIV, early treatment, HIV reservoir, ddPCR, digital PCR, acute infection, long term non progressors, elite control, TERMINAL REPEAT CIRCLES, VIRAL PERSISTENCE, IMMUNE ACTIVATION, ELITE CONTROLLERS, INFECTED PATIENTS, DNA, REPLICATION, INTEGRATION
journal title
ELIFE
ELife
volume
4
article number
e09115
pages
17 pages
Web of Science type
Article
Web of Science id
000371744900001
JCR category
BIOLOGY
JCR impact factor
8.303 (2015)
JCR rank
4/86 (2015)
JCR quartile
1 (2015)
ISSN
2050-084X
DOI
10.7554/eLife.09115
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors and the last two authors contributed equally to this work
copyright statement
I have retained and own the full copyright for this publication
id
7083004
handle
http://hdl.handle.net/1854/LU-7083004
date created
2016-02-12 10:33:56
date last changed
2016-12-21 15:42:03
@article{7083004,
  abstract     = {Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-na{\"i}ve seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.},
  articleno    = {e09115},
  author       = {Malatinkov{\'a}, Eva and De Spiegelaere, Ward and Bonczkowski, Pawel and KISELINOVA, MAJA and Trypsteen, Wim and Johnson, Margaret and Verhofstede, Chris and De Looze, Danny and Murray, Charles and Kinloch-de Loes, Sabine and Vandekerckhove, Linos},
  issn         = {2050-084X},
  journal      = {ELIFE},
  keyword      = {CD4(+) T-CELLS,IMMUNODEFICIENCY-VIRUS TYPE-1,HIV,early treatment,HIV reservoir,ddPCR,digital PCR,acute infection,long term non progressors,elite control,TERMINAL REPEAT CIRCLES,VIRAL PERSISTENCE,IMMUNE ACTIVATION,ELITE CONTROLLERS,INFECTED PATIENTS,DNA,REPLICATION,INTEGRATION},
  language     = {eng},
  pages        = {17},
  title        = {Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs},
  url          = {http://dx.doi.org/10.7554/eLife.09115},
  volume       = {4},
  year         = {2015},
}

Chicago
Malatinková, Eva, Ward De Spiegelaere, Pawel Bonczkowski, Maja Kiselinova, Wim Trypsteen, Margaret Johnson, Chris Verhofstede, et al. 2015. “Impact of a Decade of Successful Antiretroviral Therapy Initiated at HIV-1 Seroconversion on Blood and Mucosal Reservoirs.” Elife 4.
APA
Malatinková, E., De Spiegelaere, W., Bonczkowski, P., Kiselinova, M., Trypsteen, W., Johnson, M., Verhofstede, C., et al. (2015). Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs. ELIFE, 4.
Vancouver
1.
Malatinková E, De Spiegelaere W, Bonczkowski P, Kiselinova M, Trypsteen W, Johnson M, et al. Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs. ELIFE. 2015;4.
MLA
Malatinková, Eva, Ward De Spiegelaere, Pawel Bonczkowski, et al. “Impact of a Decade of Successful Antiretroviral Therapy Initiated at HIV-1 Seroconversion on Blood and Mucosal Reservoirs.” ELIFE 4 (2015): n. pag. Print.