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Complementarity and redundancy of IL-22-producing innate lymphoid cells

(2016) NATURE IMMUNOLOGY. 17(2). p.179-186
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Abstract
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR- ILC3 cells into NCR+ ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, 1122, Tbx21 and Mcl1 that NCR+ ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR+ ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.
Keywords
NATURAL-KILLER-CELLS, NK CELLS, T-CELL, COMMENSAL BACTERIA, IL-22 PRODUCTION, HOST-DEFENSE, INTERLEUKIN-22, INFLAMMATION, LYMPHOCYTES, INFECTION

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Citation

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MLA
Rankin, Lucille C et al. “Complementarity and Redundancy of IL-22-producing Innate Lymphoid Cells.” NATURE IMMUNOLOGY 17.2 (2016): 179–186. Print.
APA
Rankin, L. C., Girard-Madoux, M. J., Seillet, C., Mielke, L. A., Kerdiles, Y., Fenis, A., Wieduwild, E., et al. (2016). Complementarity and redundancy of IL-22-producing innate lymphoid cells. NATURE IMMUNOLOGY, 17(2), 179–186.
Chicago author-date
Rankin, Lucille C, Mathilde JH Girard-Madoux, Cyril Seillet, Lisa A Mielke, Yann Kerdiles, Aurore Fenis, Elisabeth Wieduwild, et al. 2016. “Complementarity and Redundancy of IL-22-producing Innate Lymphoid Cells.” Nature Immunology 17 (2): 179–186.
Chicago author-date (all authors)
Rankin, Lucille C, Mathilde JH Girard-Madoux, Cyril Seillet, Lisa A Mielke, Yann Kerdiles, Aurore Fenis, Elisabeth Wieduwild, Tracy Putoczki, Stanislas Mondot, Olivier Lantz, Dieter Demon, Anthony T Papenfuss, Gordon K Smyth, Mohamed Lamkanfi, Sebastian Carotta, Jean-Christophe Renauld, Wei Shi, Sabrina Carpentier, Tim Soos, Christopher Arendt, Sophie Ugolini, Nicholas D Huntington, Gabrielle T Bez, and Eric Vivier. 2016. “Complementarity and Redundancy of IL-22-producing Innate Lymphoid Cells.” Nature Immunology 17 (2): 179–186.
Vancouver
1.
Rankin LC, Girard-Madoux MJ, Seillet C, Mielke LA, Kerdiles Y, Fenis A, et al. Complementarity and redundancy of IL-22-producing innate lymphoid cells. NATURE IMMUNOLOGY. 2016;17(2):179–86.
IEEE
[1]
L. C. Rankin et al., “Complementarity and redundancy of IL-22-producing innate lymphoid cells,” NATURE IMMUNOLOGY, vol. 17, no. 2, pp. 179–186, 2016.
@article{7082907,
  abstract     = {Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR- ILC3 cells into NCR+ ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, 1122, Tbx21 and Mcl1 that NCR+ ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR+ ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.},
  author       = {Rankin, Lucille C and Girard-Madoux, Mathilde JH and Seillet, Cyril and Mielke, Lisa A and Kerdiles, Yann and Fenis, Aurore and Wieduwild, Elisabeth and Putoczki, Tracy and Mondot, Stanislas and Lantz, Olivier and Demon, Dieter and Papenfuss, Anthony T and Smyth, Gordon K and Lamkanfi, Mohamed and Carotta, Sebastian and Renauld, Jean-Christophe and Shi, Wei and Carpentier, Sabrina and Soos, Tim and Arendt, Christopher and Ugolini, Sophie and Huntington, Nicholas D and Bez, Gabrielle T and Vivier, Eric},
  issn         = {1529-2908},
  journal      = {NATURE IMMUNOLOGY},
  keywords     = {NATURAL-KILLER-CELLS,NK CELLS,T-CELL,COMMENSAL BACTERIA,IL-22 PRODUCTION,HOST-DEFENSE,INTERLEUKIN-22,INFLAMMATION,LYMPHOCYTES,INFECTION},
  language     = {eng},
  number       = {2},
  pages        = {179--186},
  title        = {Complementarity and redundancy of IL-22-producing innate lymphoid cells},
  url          = {http://dx.doi.org/10.1038/ni.3332},
  volume       = {17},
  year         = {2016},
}

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