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Host stress drives Salmonella recrudescence

Elin Verbrugghe (UGent) , Maarten Dhaenens (UGent) , Bregje Leyman (UGent) , Filip Boyen (UGent) , Neil Shearer, Alexander Van Parys (UGent) , Roel Haesendonck (UGent) , Wim Bert (UGent) , Herman Favoreel (UGent) , Dieter Deforce (UGent) , et al.
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Abstract
Host stress is well known to result in flare-ups of many bacterial, viral and parasitic infections. The mechanism by which host stress is exploited to increase pathogen loads, is poorly understood. Here we show that Salmonella enterica subspecies enterica serovar Typhimurium employs a dedicated mechanism, driven by the scsA gene, to respond to the host stress hormone cortisol. Through this mechanism, cortisol increases Salmonella proliferation inside macrophages, resulting in increased intestinal infection loads in DBA/2J mice. ScsA directs overall Salmonella virulence gene expression under conditions that mimic the intramacrophagic environment of Salmonella, and stimulates the host cytoskeletal alterations that are required for increased Salmonella proliferation inside cortisol exposed macrophages. We thus provide evidence that in a stressed host, the complex interplay between a pathogen and its host endocrine and innate immune system increases intestinal pathogen loads to facilitate pathogen dispersal.
Keywords
ENTERICA SEROVAR TYPHIMURIUM, PORCINE MACROPHAGES, GLOBAL BURDEN, ESCHERICHIA-COLI, PIGS, PROTEIN, STRAINS, CYTOSKELETON, NOREPINEPHRINE, INFECTIONS

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Please use this url to cite or link to this publication:

Chicago
Verbrugghe, Elin, Maarten Dhaenens, Bregje Leyman, Filip Boyen, Neil Shearer, Alexander Van Parys, Roel Haesendonck, et al. 2016. “Host Stress Drives Salmonella Recrudescence.” Scientific Reports 6.
APA
Verbrugghe, E., Dhaenens, M., Leyman, B., Boyen, F., Shearer, N., Van Parys, A., Haesendonck, R., et al. (2016). Host stress drives Salmonella recrudescence. SCIENTIFIC REPORTS, 6.
Vancouver
1.
Verbrugghe E, Dhaenens M, Leyman B, Boyen F, Shearer N, Van Parys A, et al. Host stress drives Salmonella recrudescence. SCIENTIFIC REPORTS. 2016;6.
MLA
Verbrugghe, Elin, Maarten Dhaenens, Bregje Leyman, et al. “Host Stress Drives Salmonella Recrudescence.” SCIENTIFIC REPORTS 6 (2016): n. pag. Print.
@article{7079927,
  abstract     = {Host stress is well known to result in flare-ups of many bacterial, viral and parasitic infections. The mechanism by which host stress is exploited to increase pathogen loads, is poorly understood. Here we show that Salmonella enterica subspecies enterica serovar Typhimurium employs a dedicated mechanism, driven by the scsA gene, to respond to the host stress hormone cortisol. Through this mechanism, cortisol increases Salmonella proliferation inside macrophages, resulting in increased intestinal infection loads in DBA/2J mice. ScsA directs overall Salmonella virulence gene expression under conditions that mimic the intramacrophagic environment of Salmonella, and stimulates the host cytoskeletal alterations that are required for increased Salmonella proliferation inside cortisol exposed macrophages. We thus provide evidence that in a stressed host, the complex interplay between a pathogen and its host endocrine and innate immune system increases intestinal pathogen loads to facilitate pathogen dispersal.},
  articleno    = {20849},
  author       = {Verbrugghe, Elin and Dhaenens, Maarten and Leyman, Bregje and Boyen, Filip and Shearer, Neil and Van Parys, Alexander and Haesendonck, Roel and Bert, Wim and Favoreel, Herman and Deforce, Dieter and Thompson, Arthur and Haesebrouck, Freddy and Pasmans, Frank},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {ENTERICA SEROVAR TYPHIMURIUM,PORCINE MACROPHAGES,GLOBAL BURDEN,ESCHERICHIA-COLI,PIGS,PROTEIN,STRAINS,CYTOSKELETON,NOREPINEPHRINE,INFECTIONS},
  language     = {eng},
  pages        = {9},
  title        = {Host stress drives Salmonella recrudescence},
  url          = {http://dx.doi.org/10.1038/srep20849},
  volume       = {6},
  year         = {2016},
}

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