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Host stress drives Salmonella recrudescence

Elin Verbrugghe UGent, Maarten Dhaenens UGent, Bregje Leyman UGent, Filip Boyen UGent, Neil Shearer, Alexander Van Parys UGent, Roel Haesendonck UGent, Wim Bert UGent, Herman Favoreel UGent, Dieter Deforce UGent, et al. (2016) SCIENTIFIC REPORTS. 6.
abstract
Host stress is well known to result in flare-ups of many bacterial, viral and parasitic infections. The mechanism by which host stress is exploited to increase pathogen loads, is poorly understood. Here we show that Salmonella enterica subspecies enterica serovar Typhimurium employs a dedicated mechanism, driven by the scsA gene, to respond to the host stress hormone cortisol. Through this mechanism, cortisol increases Salmonella proliferation inside macrophages, resulting in increased intestinal infection loads in DBA/2J mice. ScsA directs overall Salmonella virulence gene expression under conditions that mimic the intramacrophagic environment of Salmonella, and stimulates the host cytoskeletal alterations that are required for increased Salmonella proliferation inside cortisol exposed macrophages. We thus provide evidence that in a stressed host, the complex interplay between a pathogen and its host endocrine and innate immune system increases intestinal pathogen loads to facilitate pathogen dispersal.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ENTERICA SEROVAR TYPHIMURIUM, PORCINE MACROPHAGES, GLOBAL BURDEN, ESCHERICHIA-COLI, PIGS, PROTEIN, STRAINS, CYTOSKELETON, NOREPINEPHRINE, INFECTIONS
journal title
SCIENTIFIC REPORTS
Sci. Rep.
volume
6
article number
20849
pages
9 pages
Web of Science type
Article
Web of Science id
000369657400002
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
4.259 (2016)
JCR rank
10/64 (2016)
JCR quartile
1 (2016)
ISSN
2045-2322
DOI
10.1038/srep20849
language
English
UGent publication?
yes
classification
A1
additional info
the second and third author contributed equally to this work; correction [missing information] published in: Sci. Rep. (2016) 6;23877 ; DOI 10.1038/srep23877
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
7079927
handle
http://hdl.handle.net/1854/LU-7079927
date created
2016-02-10 13:12:41
date last changed
2018-06-21 10:24:35
@article{7079927,
  abstract     = {Host stress is well known to result in flare-ups of many bacterial, viral and parasitic infections. The mechanism by which host stress is exploited to increase pathogen loads, is poorly understood. Here we show that Salmonella enterica subspecies enterica serovar Typhimurium employs a dedicated mechanism, driven by the scsA gene, to respond to the host stress hormone cortisol. Through this mechanism, cortisol increases Salmonella proliferation inside macrophages, resulting in increased intestinal infection loads in DBA/2J mice. ScsA directs overall Salmonella virulence gene expression under conditions that mimic the intramacrophagic environment of Salmonella, and stimulates the host cytoskeletal alterations that are required for increased Salmonella proliferation inside cortisol exposed macrophages. We thus provide evidence that in a stressed host, the complex interplay between a pathogen and its host endocrine and innate immune system increases intestinal pathogen loads to facilitate pathogen dispersal.},
  articleno    = {20849},
  author       = {Verbrugghe, Elin and Dhaenens, Maarten and Leyman, Bregje and Boyen, Filip and Shearer, Neil and Van Parys, Alexander and Haesendonck, Roel and Bert, Wim and Favoreel, Herman and Deforce, Dieter and Thompson, Arthur and Haesebrouck, Freddy and Pasmans, Frank},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {ENTERICA SEROVAR TYPHIMURIUM,PORCINE MACROPHAGES,GLOBAL BURDEN,ESCHERICHIA-COLI,PIGS,PROTEIN,STRAINS,CYTOSKELETON,NOREPINEPHRINE,INFECTIONS},
  language     = {eng},
  pages        = {9},
  title        = {Host stress drives Salmonella recrudescence},
  url          = {http://dx.doi.org/10.1038/srep20849},
  volume       = {6},
  year         = {2016},
}

Chicago
Verbrugghe, Elin, Maarten Dhaenens, Bregje Leyman, Filip Boyen, Neil Shearer, Alexander Van Parys, Roel Haesendonck, et al. 2016. “Host Stress Drives Salmonella Recrudescence.” Scientific Reports 6.
APA
Verbrugghe, E., Dhaenens, M., Leyman, B., Boyen, F., Shearer, N., Van Parys, A., Haesendonck, R., et al. (2016). Host stress drives Salmonella recrudescence. SCIENTIFIC REPORTS, 6.
Vancouver
1.
Verbrugghe E, Dhaenens M, Leyman B, Boyen F, Shearer N, Van Parys A, et al. Host stress drives Salmonella recrudescence. SCIENTIFIC REPORTS. 2016;6.
MLA
Verbrugghe, Elin, Maarten Dhaenens, Bregje Leyman, et al. “Host Stress Drives Salmonella Recrudescence.” SCIENTIFIC REPORTS 6 (2016): n. pag. Print.